Abstract: The present disclosure relates to an injection device, in particular a micro dose injection device such as, for example, an ophthalmic injection device. An example device comprises a rotatable plunger; a solution receptacle having a first end configured to slidably receive the rotatable plunger and a second end configured to dispense solution contained in the solution receptacle; a first stop member configured to prevent the rotatable plunger from being slidably displaced to a second position while the rotatable plunger is at a first position and in a first orientation; and a second stop member configured to prevent the rotatable plunger from rotating in a first direction about the first axis while the rotatable plunger is at the first position and in the first orientation, wherein slidably displacing the rotatable plunger from the first position to the second position dispenses a quantity of the solution contained in the solution receptacle.

Abstract: An apparatus for aerosolized powder delivery includes first and second chambers containing gas at first and second pressures, respectively, above atmospheric pressure. A powder is contained within the first or second chamber. The first chamber has a first external wall and a separating wall shared with the second chamber. The first external wall or the separating wall is configured to rupture if the pressure difference across it becomes equal to or greater than a threshold pressure difference. Specifically, the apparatus is configured so that the difference between the second pressure and atmospheric pressure is greater than the threshold pressure difference. Initially, the difference between the second and first pressures is less than the pressure difference required to rupture the separating wall, and the difference between the first pressure and atmospheric pressure is less than the pressure difference required to rupture the first external wall.

Abstract: A spray device (6) for the delivery of a therapeutic agent, the spray device (6) comprises a nozzle (1) having a first port (3) to input a gas source of positive gas pressure; a second port (4) to output gas from the gas source; and a Coanda surface (5) and a third port (2) between, and in fluid connection with, the first port (3) and the second port (4). The nozzle (1) is arranged such that, in use, a gas including a therapeutic agent enters the first port (3), the therapeutic agent having sufficient momentum to overcome forces from the gas flow over the Coanda surface (5) such that the therapeutic agent is ejected at the third port (2) in the form of a spray.

Abstract: The invention provides an apparatus for use in aerosolized delivery of a powder, and comprises a first chamber containing gas at a first pressure higher than atmospheric pressure, and a second chamber containing gas at a second pressure higher than atmospheric pressure. The apparatus also comprises a powder, contained within the first or second chamber. The first chamber has a first external wall and a separating wall, the separating wall being shared with the second chamber. The first external wall or the separating wall is configured to rupture if the pressure difference across it becomes equal to or greater than a threshold pressure difference. In particular, the apparatus is configured so that the difference between the second pressure and atmospheric pressure is greater than the threshold pressure difference.

Abstract: A dry powder inhaler comprises two parts (2, 4) connected by an integrally molded, e.g. living hinge (6), so as to be moveable from an open position to a closed position. At least one of the parts (2, 4) defines at least part of a circulating airflow chamber (12), wherein when said parts (2, 4) are in said closed position, the inhaler comprises an airflow path including the circulating airflow chamber (12).

Abstract: The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.

Abstract: A dry powder inhaler has a main airflow path including a cyclone chamber (16) having an air inlet and being so shaped that at least a part of the chamber decreases in cross-sectional area in a direction away from the air inlet, so as thereby in use to set up a reverse flow cyclone in the chamber. A bypass airflow path (8) bypasses the cyclone chamber and the main and bypass airflow paths communicate with a mouthpiece (6). The cyclone chamber may be provided by a part (22) which is removable from the rest of the inhaler for regular replacement thereof.

Abstract: A method of filling a drug capsule (2) for a dry powder inhaler comprising introducing a dose of powdered active substance (4) into the capsule and introducing a separate quantity of filler particles (6) into the capsule (2), said filler particles being of different composition and having a larger average particle size than the active substance.

Abstract: The present invention relates to an inhalation-activatable device for administration of medicament in powder form to the respiratory system of a patient.

Abstract: A brewing receptacle for an apparatus for brewing a beverage such as coffee. The receptacle has a brewing chamber (13; 63; 113) having an entry passage and an exit passage for displacing water through the chamber (13; 63; 113) for brewing the beverage, a bottom (14; 64; 114) for supporting the particles (18; 118, 118?) (18), and a discharge 5 opening (19; 69; 119) in the bottom (14; 64; 114) for discharging beverage liquid through the bottom (14; 64; 114). At least the bottom (14; 64; 114) is invertible between a first and a second operative position. The brewing chamber (13; 63; 113) has a first volume and a first shape when the bottom (14; 64; 114) is in said first position and at least a second volume or a second shape of the brewing chamber in said second position is different from the first volume or shape, respectively.

Abstract: A dry powder inhaler comprises two parts (2, 4) connected by an integrally moulded, e.g. living hinge (6), so as to be moveable from an open position to a closed position. At least one of the parts (2, 4) defines at least part of a circulating airflow chamber (12), wherein when said parts (2, 4) are in said closed position, the inhaler comprises an airflow path including the circulating airflow chamber (12).

Abstract: A dry powder inhaler comprises: a cyclone chamber having a cyclone chamber outlet (20) extending substantially axially therefrom; a mouthpiece channel (26) having a central axis; and a plenum portion (58) connecting said cyclone chamber outlet (20) and said mouthpiece channel, the mouthpiece channel axis Am being offset from, and making a non-parallel angle with, the axis of the cyclone outlet Ac such that in use air exits the cyclone outlet (20) at least partly tangentially into the mouthpiece (28).

Abstract: A beverage making device comprising a brewing chamber for enclosing a pad (6) containing a substance from which the beverage is to be brewed. The brewing chamber is formed by an upper part with one or more openings (5) for supplying water to the brewing chamber and by a lower part (8) with an outflow opening (16) through which the brewed beverage can leave the brewing chamber. Beverage receiving means (10,11) are present below said lower part (8). One or more further openings (22) are present between the brewing chamber and the beverage receiving means (10,11), and means for closing said one or more further openings (22) during the brewing process are present.

Abstract: A dry powder inhaler comprises a main airflow path including a cyclone chamber (16) having an air inlet and being so shaped that at least a part of the chamber decreases in cross-sectional area in a direction away from the air inlet, so as thereby in use to set up a reverse flow cyclone in the chamber. A bypass airflow path (8) bypasses the cyclone chamber and the main and bypass airflow paths communicate with a mouthpiece (6). The cyclone chamber may be provided by a part (22) which is removable from the rest of the inhaler for regular replacement thereof.

Abstract: A cyclonic separating apparatus includes at least one cyclone having a first end, a second end a longitudinal axis. An inlet is located at the first end for introducing a fluid flow into the cyclone, and a cone opening is located at the second end.

Abstract: A vacuum cleaner comprises a cyclonic separator (116) for separating dirt and dust from an incoming airflow. A tool (300) and a suction conduit (114) connect the tool (300) to the separator (116). The tool (300) comprises a main air inlet aperture for engaging with a surface to be cleaned and a bleed air inlet (310) for allowing air to bleed into the suction path. The bleed air inlet (310) is located such that it is separate from the main inlet. The cross-sectional area of the bleed air inlet (310) is sufficiently large that, in use, the bleed air inlet (310) admits a sufficient quantity of air to maintain adequate separation efficiency in the separator of the cleaner even when the main air inlet is fully blocked.

Abstract: A vacuum cleaner comprises a cyclonic separator (116) for separating dirt and dust from an incoming airflow. A tool (300) and a suction conduit (114) connect the tool (300) to the separator (116). The tool (300) comprises a main air inlet aperture for engaging with a surface to be cleaned and a bleed air inlet (310) for allowing air to bleed into the suction path. The bleed air inlet (310) is located such that it is separate from the main inlet. The cross-sectional area of the bleed air inlet (310) is sufficiently large that, in use, the bleed air inlet (310) admits a sufficient quantity of air to maintain adequate separation efficiency in the separator of the cleaner even when the main air inlet is fully blocked.