Publication number: 20100036115
Abstract: This invention features permeability enhancer molecules, and methods, to increase membrane permeability of various molecules, such as nucleic acids, polynucleotides, oligonucleotides, enzymatic nucleic acid molecules, antisense nucleic acid molecules, 2-5A antisense chimeras, triplex forming oligonucleotides, decoy RNAs, dsRNAs, siRNAs, aptamers, or antisense nucleic acids containing nucleic acid cleaving chemical groups, peptides, polypeptides, proteins, carbohydrates, steroids, metals and small molecules, thereby facilitating cellular uptake of such molecules.
Type:
Application
Filed:
May 21, 2009
Publication date:
February 11, 2010
Applicant:
Sirna Therapeutics, Inc.
Inventors:
Leonid Beigelman, Nilabh Chaudhary, Peter Haeberli, Alexander Karpeisky, Jasenka Matulic-Adamic, John Min, Mark Reynolds, David Sweedler