Patents by Inventor David T. Yue

David T. Yue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput screen utilizing newly discovered intramolecular neuronal calcium channel interactions to discover new analgesics
    Patent number: 7985736
    Abstract: The present invention relates to compositions to treat CaV2 disorders. The invention also relates to methods treating CaV2 disorders. The invention further relates to kits for treating CaV2 disorders in a subject. The invention further relates to methods of identifying novel treatments for treating Cav2 disorders in a subject.
    Type: Grant
    Filed: December 14, 2005
    Date of Patent: July 26, 2011
    Assignee: The John Hopkins University
    Inventors: David T. Yue, Heather L. Agler
  • High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel Interactions To Discover New Analgesics
    Publication number: 20080279864
    Abstract: The present invention relates to compositions to treat CaV2 disorders. The invention also relates to methods treating CaV2 disorders. The invention further relates to kits for treating CaV2 disorders in a subject. The invention further relates to methods of identifying novel treatments for treating Cav2 disorders in a subject.
    Type: Application
    Filed: December 14, 2005
    Publication date: November 13, 2008
    Applicant: The Johns Hopkins University
    Inventors: David T. Yue, Heather L. Agler
  • Three cube fret method (3-fret) for detecting fluorescence energy transfer
    Publication number: 20040191786
    Abstract: The invention provides a method for determining a measure of FRET comprising obtaining sequential fluorescent intensity readings from a specimen, such as a cell using three filter cubes. Simple equations manipulate readings from each of the filter sets or cubes to specify a unitless index of FRET called the FRET ratio (FR). FR bears a linear relation to FRET efficiency E. The method also provides for determining the fraction of acceptor-tagged molecules bound by donor-tagged molecules; the relative affinity of binding; and the strength of FRET interactions when all acceptor-tagged molecules are bound by donor. The latter determination enables estimates of the physical distance and/or orientation between interacting fluorophore molecules. The method can be used to detect analytes or inter- or intramolecular interactions. In a preferred aspect, the method is used in an HTS assay to identify modulators of such interactions.
    Type: Application
    Filed: December 18, 2003
    Publication date: September 30, 2004
    Inventors: David T. Yue, Michael G. Erickson