Abstract: A playback device detects a first playback condition and a second playback condition related to an identified first user of a first media playback system. The playback device identifies an audio track associated with each of the first playback condition and the second playback condition. The playback device detects a third playback condition related to a geographical location, and based on the detected third playback condition, plays back audio content beginning with the identified audio track.

Abstract: A media sharing and communication system, including a recording mechanism that records a desired portion of media upon activation by a first individual user, a first user transmitter/receiver that transmits the portion of media and a message generated by the first individual user regarding the portion of media to a second individual user and is capable of transmitting a message to a second individual user, a confirmation mechanism that confirms that the second individual user is authorized to view the portion of media, a notification mechanism that notifies the first individual user if the second individual user is not authorized to receive the portion of media, a second user transmitter/receiver that receives the portion of media and voice message upon authorization of the second individual user, and a search mechanism for searching for media and products used in media. A method of sharing portions of media.

Abstract: A series of 2-imino-6-methyltetrahydropyrimidin-4(1H)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

Abstract: A storage system for temporary storage of a gas comprising a storage vessel configured to store a pressurized gas or liquid; at least one of a compressor configured to pressurize the gas and provide the pressurized fluid or a liquefaction apparatus operable to liquefy the gas to provide the liquid; and piping associated with one or more valves, wherein the piping and the associated one or more valves are configured to provide: (a) in a first configuration, inflow of the gas into the compressor or the liquefaction apparatus, wherein the compressor is configured to pressurize the inflowing gas to provide the pressurized fluid or wherein the liquefaction apparatus is configured to liquefy the inflowing gas to provide the liquid, and introduce the pressurized gas or the liquid into the temporary storage vessel; and (b) in a second configuration, outflow of the pressurized gas or liquid from the temporary storage vessel.

Abstract: Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive hydroxyeicosatetraenoic acid (HETE) metabolites. These eicosanoid signaling molecules are involved in a number of physiologic responses such as platelet aggregation, inflammation, and cell proliferation. Platelet-type 12-(S)-LOX (12-LOX) is of particular interest because of its demonstrated role in skin diseases, diabetes, platelet hemostasis, thrombosis, and cancer. Disclosed herein is the identification and medicinal chemistry optimization of a 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide-based scaffold. The compounds display nM potency against 12-LOX and excellent selectivity over related lipoxygenases and cyclooxygenases. In addition to possessing favorable ADME properties, the compounds also inhibit PAR-4 induced aggregation and calcium mobilization in human platelets, and reduce 12-HETE in mouse/human beta cells.

Abstract: A method for configuring, via a website, a computing device to communicate with a printer is described. The method includes creating, via the website, a printer definition for the printer. The printer definition includes a network address, a reference to a printer driver, and a reference to a printer profile. The method also includes sending an install uniform resource identifier (URI) associated with the printer definition. The method further includes receiving an indication that the install URI has been activated by the computing device. The method additionally includes sending an installer to the computing device. The installer installs the printer driver and configures the computing device to communicate with the printer using the network address, the printer driver and the printer profile.

Abstract: A media sharing and communication system, including a recording mechanism that records a desired portion of media upon activation by a first individual user, a first user transmitter/receiver that transmits the portion of media and a message generated by the first individual user regarding the portion of media to a second individual user and is capable of transmitting a message to a second individual user, a confirmation mechanism that confirms that the second individual user is authorized to view the portion of media and a notification mechanism that notifies the first individual user if the second individual user is not authorized to receive the portion of media, and a second user transmitter/receiver that receives the portion of media and voice message upon authorization of the second individual user, wherein the systems are capable of receiving and executing voice commands. A method of sharing portions of media.

Abstract: A media sharing and communication system, including a recording mechanism that records a desired portion of media upon activation by a first individual user, a first user transmitter/receiver that transmits the portion of media and a voice message generated by the first individual user regarding the portion of media to a second individual user and is capable of transmitting a message to a second individual user during a live program, a confirmation mechanism that confirms that the second individual user is authorized to view the portion of media and a notification mechanism that notifies the first individual user if the second individual user is not authorized to receive the portion of media, and a second user transmitter/receiver that receives the portion of media and voice message upon authorization of the second individual user. A method of sharing portions of media and watching a live program.

Abstract: An outlet guide vane for a turbofan engine, which results in reduced noise. The outlet guide vane may comprise an aerofoil, the aerofoil comprising at least porous section, wherein the at least one channel or porous section is positioned near the leading edge of the aerofoil.

Abstract: A media sharing and communication system, including a recording mechanism that records a desired portion of media upon activation by a first individual user, a first user transmitter/receiver that transmits the portion of media and a voice message generated by the first individual user regarding the portion of media to a second individual user, a confirmation mechanism that confirms that the second individual user is authorized to view the portion of media and a notification mechanism that notifies the first individual user if the second individual user is not authorized to receive the portion of media, and a second user transmitter/receiver that receives the portion of media and voice message upon authorization of the second individual user. A method of sharing portions of media.

Abstract: A computing device detects a first playback condition indicating a presence of a user in a zone in a media playback system. The computing device determines a second playback condition that corresponds to the detected presence of the user in the zone. Characteristics of at least one audio track are compared to (i) the indication of the presence of the user in the zone and (ii) the second playback condition. Audio content is identified based on the comparison and the identified audio content is played in the zone.

Abstract: Computer-implemented methods of designing an antibody that will bind to a target epitope are disclosed. In one arrangement, the method comprises identifying one or more hotspot residues that will each bind to a corresponding one of one or more hotspot sites on the target epitope. Candidate antibody structures are selected from a database such that characteristic atoms within the antibody structure and hotspot characteristic atoms can be superimposed computationally with an averaged spatial deviation less than a predetermined threshold. A designed antibody is generated by replacing matching residues with different residues such that a predicted affinity is increased.

Abstract: A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: System, method, and apparatus including receiving an identification of content played by a playback system and an identification of location of the playback system. A playlist of content is associated with the location. A request is received to retrieve the playlist of content and the requested playlist of content is sent to a playback system.

Abstract: A microfluidic probe includes a probe head with a processing surface that includes a first aperture and a second aperture. The probe further includes a liquid injection channel, which leads to the first aperture, and a liquid aspiration channel, which extends from the second aperture. The probe also includes a bypass channel, arranged so as to fluidly connect the liquid injection channel to the liquid aspiration channel, as well as a control channel. The latter fluidly connects to the bypass channel, hence forming a junction therewith, so as to define two portions of the bypass channel. These portions includes: a first portion that extends from the junction to the liquid injection channel; and a second portion that extends from that same junction to the liquid aspiration channel. The invention is further directed to methods of operation of a probe as described above, to process a surface.

Abstract: A media sharing and communication system, including a recording mechanism that records a desired portion of media upon activation by a first individual user, a first user transmitter/receiver that transmits the portion of media and a voice message generated by the first individual user regarding the portion of media to a second individual user and is capable of transmitting a message to a second individual user during a live program, a confirmation mechanism that confirms that the second individual user is authorized to view the portion of media and a notification mechanism that notifies the first individual user if the second individual user is not authorized to receive the portion of media, and a second user transmitter/receiver that receives the portion of media and voice message upon authorization of the second individual user. A method of sharing portions of media and watching a live program.

Abstract: A wall panel may have a rigid layer, a first insulation layer made from a two-part rigid urethane pour foam, and a second insulation layer made from a phase change material. The first insulation layer maybe chemically bonded to the rigid layer and may also be bonded to the phase change layer. The first insulation layer may be positioned between the second insulation layer and the rigid layer. The rigid layer may be a finished surface or a veneer layer may be applied to the rigid layer.

Abstract: A smart card (1) interfaces with a smart card reader (2) to generate an authentication message (PSRQ), which is sent to a PIN servicing centre (5, 6). If the authentication message (PSRQ) is validated by the PIN servicing centre (5, 6), a validation response message (PSRS) is sent back to the user (3). The user (3) enters the validation response message (PSRS) on the reader (2), which authenticates the validation response message (PSRS) with the smart card (1); the PIN servicing function may then be performed. The smart card cryptographic messages are generated internally and solely by the smart card (1)—the reader (2) acts merely as an input mechanism into the smart card (1) or as an output mechanism from the smart card (1) to the display (10). The reader (2), therefore, does not need to contain any customer information or be personalised by the card issuer.

Abstract: A microfluidic probe includes a probe head with a processing surface that includes a first aperture and a second aperture. The probe further includes a liquid injection channel, which leads to the first aperture, and a liquid aspiration channel, which extends from the second aperture. The probe also includes a bypass channel, arranged so as to fluidly connect the liquid injection channel to the liquid aspiration channel, as well as a control channel. The latter fluidly connects to the bypass channel, hence forming a junction therewith, so as to define two portions of the bypass channel. These portions includes: a first portion that extends from the junction to the liquid injection channel; and a second portion that extends from that same junction to the liquid aspiration channel. The invention is further directed to methods of operation of a probe as described above, to process a surface.

Abstract: The present invention relates to a radar apparatus for vehicle comprising: a transmission unit configured to transmit a transmission signal; a reception unit configured to receive a reception signal that is a reflected transmission signal by an object; and a processor configured to process the reception signal, wherein the transmission unit comprises: a plurality of transmission antennas; and a code generator configured to assign a different code to each of the plurality of antennas, wherein the reception unit comprises a plurality of reception antennas, each of which receives a reception signal based on a signal transmitted from each of the plurality of transmission antennas.