Abstract: A tethered laparoscopic probe is provided, the tethered laparoscopic probe for deployment through a trocar into a cavity of a subject to detect gamma radiation from a radiopharmaceutical administered to the subject. The laparoscopic probe comprises a probe head shaped for insertion through the trocar and configured to be freely moveable within the cavity. The probe head comprises an elongate casing comprising radiation shielding for inhibiting gamma radiation from passing through the probe head, the radiation shielding having a detection aperture for admitting gamma radiation. The probe head further comprises a gamma radiation detector arranged within the casing, the gamma radiation detector configured to detect gamma radiation through the detection aperture of the casing. The probe head further comprises means for, in use, facilitating the localization of a source of radiation from the radiopharmaceutical within the cavity.

Abstract: The present application provides apparatus for simulating radio-guided surgery using a light source (8) and a probe (13) having a light detector (16). Specifically, the apparatus includes a subject model (1) that has an enclosure (6) with an opening (4, 5) that extends from an exterior of the subject model (1) into the enclosure (6). The subject model (1) also includes a light source (8) that is disposed within the enclosure (6). The apparatus also includes a probe (13) for deployment by a user through the opening (4, 5) into the enclosure (6). The probe (13) has a light detector (16) configured to detect light emitted by the light source (8) for localization of the light source (8) within the enclosure (6).

Abstract: Scintillator products, apparatuses and methods are provided for use in autoradiographic imaging of a tissue sample excised from a subject. In particular, scintillator products and devices are provided that are substantially conformable to a surface of the excised tissue sample and configured to scintillate, in use, in response to radiation from a radiopharmaceutical administered to the subject in advance of the excision.

Abstract: A tethered laparoscopic probe is provided, the tethered laparoscopic probe for deployment through a trocar into a cavity of a subject to detect gamma radiation from a radiopharmaceutical administered to the subject. The laparoscopic probe comprises a probe head shaped for insertion through the trocar and configured to be freely moveable within the cavity. The probe head comprises an elongate casing comprising radiation shielding for inhibiting gamma radiation from passing through the probe head, the radiation shielding having a detection aperture for admitting gamma radiation. The probe head further comprises a gamma radiation detector arranged within the casing, the gamma radiation detector configured to detect gamma radiation through the detection aperture of the casing. The probe head further comprises means for, in use, facilitating the localization of a source of radiation from the radiopharmaceutical within the cavity.

Abstract: A tethered laparoscopic probe for deployment through a trocar into a cavity of a subject and manipulatable by fenestrated laparoscopic graspers includes opposing fenestrated jaws. The tethered laparoscopic probe also includes a probe head shaped for insertion through the trocar and including an elongated casing, a sensor arranged within the casing and defining a sensing direction of the probe head, and a grip for secure grasping by the fenestrated laparoscopic graspers. The grip has protrusions for mating with the fenestrated jaws. The tethered laparoscopic probe further includes a tether coupled to the probe head. The protrusions are positioned and shaped to enable the grip to be grasped securely by the fenestrated laparoscopic graspers at a first angle relative to the sensing direction of the probe head and at a second angle relative to the sensing direction of the probe head, the second angle being different from the first angle.

Abstract: A tethered laparoscopic probe is provided, the tethered laparoscopic probe for deployment through a trocar into a cavity of a subject to detect gamma radiation from a radiopharmaceutical administered to the subject. The laparoscopic probe comprises a probe head shaped for insertion through the trocar and configured to be freely moveable within the cavity. The probe head comprises an elongate casing comprising radiation shielding for inhibiting gamma radiation from passing through the probe head, the radiation shielding having a detection aperture for admitting gamma radiation. The probe head further comprises a gamma radiation detector arranged within the casing, the gamma radiation detector configured to detect gamma radiation through the detection aperture of the casing. The probe head further comprises means for, in use, facilitating the localization of a source of radiation from the radiopharmaceutical within the cavity.

Abstract: A detection device for detecting radiation from a radiopharmaceutical administered to a subject includes a radiation sensor having a plurality of metal-oxide-semiconductor (MOS) components providing a pixel array, a semiconductor of the MOS components being configured for interaction charge carriers to be created in the depletion layer of the semiconductor in response to direct interaction with received charged particles emitted from the radiopharmaceutical. The detection device further comprises a light sealing covering arranged to prevent light from impinging on the pixel array. A laparoscopic probe, a handheld device and a specimen imaging chamber are also disclosed, and methods for operating the detection devices described herein.

Abstract: An apparatus for optical imaging of a low radiance object is disclosed. The apparatus comprises a fixed polychromatic imaging device, the optical path between the polychromatic imaging device and the low radiance object being defined by a first section extending from the polychromatic imaging device to a fixed point, and a second section extending from the fixed point to the low radiance object. The apparatus also comprises a fixed high-sensitivity imaging device, the optical path between the high-sensitivity imaging device and the low radiance object being defined by a third section extending from the high-sensitivity imaging device to the fixed point, and the second section; and a focus controller arranged to control the focus of the high-sensitivity imaging device based on the focus of the polychromatic imaging device and the respective lengths of the first and third sections.

Abstract: Apparatus for optical imaging of Cerenkov luminescence from an object subsequent to the object receiving a dose of a radiopharmaceutical, the apparatus comprising: a light tight enclosure within which the object can be received at a sample location; an imaging means; a means to mitigate direct particle impingement between the sample location and the imaging means; and one or more optical elements for transmitting Cerenkov photons from within the light tight enclosure to the imaging means.

Abstract: A fiberscope comprises a scintillator arranged to produce light of a first wavelength upon exposure to radiation; an optical system arranged to receive and direct light of the first wavelength emitted from the scintillator, the light being received at one end of the optical system, and wherein one or more elements of the optical system emits scintillation light of a second wavelength upon exposure to radiation; and an optical filter, disposed at the other end of the optical system, and arranged to transmit light of the first wavelength and block light of the second wavelength. The scintillator is chosen such that the light of the first wavelength is spectrally distinct from the light of the second wavelength.

Abstract: A fibrescope comprises a scintillator arranged to produce light of a first wavelength upon exposure to radiation; an optical system arranged to receive and direct light of the first wavelength emitted from the scintillator, the light being received at one end of the optical system, and wherein one or more elements of the optical system emits scintillation light of a second wavelength upon exposure to radiation; and an optical filter, disposed at the other end of the optical system, and arranged to transmit light of the first wavelength and block light of the second wavelength. The scintillator is chosen such that the light of the first wavelength is spectrally distinct from the light of the second wavelength.

Abstract: An apparatus for optical imaging of a low radiance object is disclosed. The apparatus comprises a fixed polychromatic imaging device, the optical path between the polychromatic imaging device and the low radiance object being defined by a first section extending from the polychromatic imaging device to a fixed point, and a second section extending from the fixed point to the low radiance object. The apparatus also comprises a fixed high-sensitivity imaging device, the optical path between the high-sensitivity imaging device and the low radiance object being defined by a third section extending from the high-sensitivity imaging device to the fixed point, and the second section; and a focus controller arranged to control the focus of the high-sensitivity imaging device based on the focus of the polychromatic imaging device and the respective lengths of the first and third sections.

Abstract: The present invention provides a labelled compound suitable for use as an in vivo imaging agent. The in vivo imaging agent of the invention is useful in the in vivo diagnosis and imaging of fibrosis and in particular fibrosis in the liver. Also provided by the present invention is a method for the preparation of the labelled compound of the invention and a precursor compound useful in said method and a kit useful for carrying out said method. In addition, the present invention provides a pharmaceutical composition comprising the labelled compound of the invention as well as a method of in vivo imaging using the labelled compound of the invention, preferably as the pharmaceutical composition of the invention.

Abstract: Apparatus for optical imaging of Cerenkov luminescence from an object subsequent to the object receiving a dose of a radiopharmaceutical, the apparatus comprising: a light tight enclosure within which the object can be received at a sample location; an imaging means; a means to mitigate direct particle impingement between the sample location and the imaging means; and one or more optical elements for transmitting Cerenkov photons from within the light tight enclosure to the imaging means.

Abstract: An apparatus for optical imaging of Cerenkov luminescence from a region of interest on a subject subsequent to the subject receiving a dose of a radiopharmaceutical, the apparatus comprising: an imaging means capable of imaging Cerenkov photons; a fibrescope for transmitting light received at a distal end of the fibrescope to a proximal end of the fibrescope, the proximal end of the fibrescope being connected to the imaging means; and an optical shroud for surrounding the distal end of the fibrescope and for covering a region of interest.