Patents by Inventor David W. Leung
David W. Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100189726Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.Type: ApplicationFiled: September 29, 2009Publication date: July 29, 2010Applicant: Cell Therapeutics, Inc.Inventors: Lynn BONHAM, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung, Baoqing Gong, John Tulinsky
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Patent number: 7608620Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.Type: GrantFiled: November 16, 2006Date of Patent: October 27, 2009Assignee: Cell Therapeutics, Inc.Inventors: Lynn Bonham, Baoqing Gong, Robert E Finney, David M Hollenback, J Peter Klein, David W Leung, Scott A Shaffer, Norina M Tang, John Tulinsky, Thayer H White
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Publication number: 20080176288Abstract: A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.Type: ApplicationFiled: October 30, 2007Publication date: July 24, 2008Inventors: David W. Leung, Philip A. Bergman, Alan Lofquist, Gregory E. Pietz, Christopher K. Tompkins, David W. Waggoner
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Patent number: 7199238Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.Type: GrantFiled: September 12, 2005Date of Patent: April 3, 2007Assignee: Cell Therapuetics, Inc.Inventors: Lynn Bonham, Baoqing Gong, Robert E Finney, David M Hollenback, J. Peter Klein, David W Leung, Scott A Shaffer, Norina M Tang, John Tulinsky, Thayer H White
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Patent number: 7135314Abstract: This invention relates to a biotechnology invention concerning human phosphatidic acid phosphatase. More particularly, this invention relates to three variants of human phosphatidic acid phosphatase namely PAP-?(1 and 2), PAP-? and PAP-? and uses thereof.Type: GrantFiled: April 17, 1997Date of Patent: November 14, 2006Assignee: Cell Therapeutics, Inc.Inventors: David W. Leung, Christopher K. Tompkins
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Patent number: 7064125Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase ? (LPAAT-?) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-? activity.Type: GrantFiled: November 13, 2003Date of Patent: June 20, 2006Assignee: Cell Therapeutics, Inc.Inventors: Baoqing Gong, John Tulinsky, Lynn Bonham, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung
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Patent number: 7052891Abstract: Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.Type: GrantFiled: September 23, 2003Date of Patent: May 30, 2006Assignee: Cell Therapeutics Inc.Inventors: David W. Leung, Daniel Adourel, David Hollenback
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Patent number: 7045327Abstract: Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.Type: GrantFiled: September 23, 2003Date of Patent: May 16, 2006Assignee: Cell Therapeutics Inc.Inventors: David W. Leung, Daniel Adourel, David Hollenback
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Patent number: 6973419Abstract: A method and system for designing an impingement film floatwall panel system for a combustion chamber for a gas turbine engine comprising the steps of creating an impingement film floatwall panel knowledge base of information. The knowledge base has a plurality of design rule signals with respect to a corresponding plurality of parameter signals of associated elements of impingement film floatwall panels for a combustion chamber, wherein the knowledge base comprises at least one data value signal for each one of the plurality of design rule signals. The steps also include entering a desired data value signal for a selected one of the plurality of parameter signals of an associated element of the impingement film floatwall panels and comparing the entered desired data value signal for the selected one of the plurality of parameters with the corresponding at least one data value signal in the knowledge base for the corresponding one of the plurality of design rule signals.Type: GrantFiled: March 2, 2000Date of Patent: December 6, 2005Assignee: United Technologies CorporationInventors: Thomas B. Fortin, Gregory E. Chetta, David W. Leung, Duncan C. Meyers, Keith C. Belson, John V. Diaz, Thomas E. Holladay, Scott A. Ladd, Randall G. McKinney, Sergio Rinella, Andreas Sadil, George F. Titterton, III
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Patent number: 6944580Abstract: A method for designing an engine case static structure of a gas turbine engine includes creating signals representing an engine case static structure knowledge base of information. The knowledge base has a plurality of design rule signals with respect to a corresponding plurality of parameter signals of associated elements of an engine case static structure, wherein the knowledge base comprises at least one data value signal for each of the plurality of design rule signals. A desired data value signal is entered for a selected one of the plurality of parameter signals of an associated element of the engine case static structure and compared to the corresponding data value signal in the knowledge base for the corresponding one of the plurality of design rule signals. Signals representative of a geometric representation of the selected parameter signal may be created.Type: GrantFiled: June 30, 2000Date of Patent: September 13, 2005Assignee: United Technologies CorporationInventors: Karl Blume, Dennis L. Mackey, Amy U. Serwinowski, David W. Leung, Charlie Quackenbush, Jeffrey Simpson, Duncan C. Meyers, Frank Shurick, Henry Huizinga, Robert Rozelle, Gregory E. Chetta, Jonathan Schmid
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Publication number: 20040162288Abstract: The invention relates to triazines and the use thereof to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity. The invention further relates to methods of treating cancer using said triazines. The invention also relates to methods for screening for LPAAT-&bgr; activity.Type: ApplicationFiled: November 13, 2003Publication date: August 19, 2004Applicant: Cell Therapeutics, Inc.Inventors: Baoqing Gong, John Tulinsky, Lynn Bonham, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung
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Publication number: 20040086996Abstract: Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.Type: ApplicationFiled: September 23, 2003Publication date: May 6, 2004Applicant: CELL THERAPEUTICS, INC.Inventors: David W. Leung, Daniel Adourel, David Hollenback
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Publication number: 20040082049Abstract: Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.Type: ApplicationFiled: September 23, 2003Publication date: April 29, 2004Applicant: CELL THERAPEUTICS, INC.Inventors: David W. Leung, Daniel Adourel, David Hollenback
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Publication number: 20040043465Abstract: Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.Type: ApplicationFiled: September 23, 2003Publication date: March 4, 2004Applicant: CELL THERAPEUTICS, INC.Inventors: David W. Leung, Daniel Adourel, David Hollenback
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Patent number: 6670143Abstract: Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.Type: GrantFiled: October 5, 2001Date of Patent: December 30, 2003Assignee: Cell Therapeutics, Inc.Inventors: David W. Leung, Daniel Adourel, David Hollenback
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Patent number: 6503700Abstract: There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.Type: GrantFiled: March 31, 1999Date of Patent: January 7, 2003Assignee: Cell Therapeutics, Inc.Inventor: David W. Leung
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Publication number: 20020169125Abstract: A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic polymer to increase its biological half-life and/or solubility. The instant invention also provides a method for targeting the delivery of a polyanionic polymer conjugate or fusion protein to a specific cell type or tissue.Type: ApplicationFiled: March 20, 2002Publication date: November 14, 2002Applicant: CELL THERAPEUTICS, INC.Inventors: David W. Leung, Philip A. Bergman, Alan Lofquist, Gregory E. Pietz, Christopher K. Tompkins, David W. Waggoner
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Publication number: 20020168747Abstract: There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylyltransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.Type: ApplicationFiled: May 2, 2002Publication date: November 14, 2002Applicant: CELL THERAPEUTICS, INC.Inventor: David W. Leung
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Publication number: 20020156262Abstract: Polypeptides are obtained, for example, via expression of encoding cDNA sequences, that have the activity of the enzyme lysophosphatidic acid acyltransferase (LPAAT), also known as 1-acyl sn-glycerol-3-phosphate acyltransferase.Type: ApplicationFiled: October 5, 2001Publication date: October 24, 2002Inventors: David W. Leung, Daniel Adourel, David Hollenback
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Publication number: 20020107269Abstract: The invention relates to benzoxazoles and the use thereof to inhibit lysophosphatidic acid acyltransferase &bgr; (LPAAT-&bgr;) activity. The invention further relates to methods of treating cancer using said benzoxazoles. The invention also relates to methods for screening for LPAAT-&bgr; activity.Type: ApplicationFiled: October 31, 2001Publication date: August 8, 2002Applicant: CELL THERAPEUTICS, INC.Inventors: Lynn Bonham, J. Peter Klein, Robert E. Finney, David M. Hollenback, Scott A. Shaffer, Norina M. Tang, Thayer H. White, David W. Leung