Patents by Inventor David W. M. Marr
David W. M. Marr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10722250Abstract: The invention relates to a magnetic-field driven colloidal microbot that employs wall-based propulsion, method of forming the microbot and a method of using the microbot. The microbot can be formed in situ with the use of magnetic fields, and the magnetic fields can be used to translate the microbot to a specified location in a patient. The microbot does not depend on “swimming” or flow currents within a patient to move, but instead can propel itself along a surface using a magnetic field. Once the magnetic field is removed, the microbot disassembles into colloidal particles.Type: GrantFiled: March 14, 2016Date of Patent: July 28, 2020Assignee: Colorado School of MinesInventors: Tonguc Onur Tasci, Keith B. Neeves, David W. M. Marr
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Patent number: 9885644Abstract: The present invention generally relates to a method for determining the dynamic viscoelastic properties of cells, more particularly to a method for rapidly determining the dynamic viscoelastic properties of healthy and unhealthy cells by determining the phase shift be the application of a modulating force to the cells and the cells' response to the modulating force.Type: GrantFiled: June 17, 2014Date of Patent: February 6, 2018Assignees: Colorado School of Mines, National Institute of Health, University of MarylandInventors: Tobias Sawetzki, David W. M. Marr, Charles Eggleton, Sanjay Desai
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Patent number: 9878326Abstract: The direct integration of light and optical control into microfluidic systems presents a significant hurdle to the development of portable optical trapping-based devices. A simple, inexpensive fiber-based approach is provided that allows for easy implementation of diode-bars for optical particle separations within flowing microfluidic systems. Models have also been developed that demonstrate the advantages of manipulating particles within flow using linear geometries as opposed to individually focused point traps as traditionally employed in optical-trapping micromanipulation.Type: GrantFiled: September 26, 2008Date of Patent: January 30, 2018Assignee: Colorado School of MinesInventors: Jeff Squier, David W. M. Marr, Robert Applegate, Tor Vestad
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Patent number: 9487812Abstract: A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel, each of which are carrying one or more objects. There is an intersection between the first and second microfluidic channels where one or more objects from the first microfluidic channel impact one or more objects from the second microfluidic channel under hydrodynamic forces. The impact causes the objects to deform and the deformation of objects can be analyzed to determine properties of the object.Type: GrantFiled: February 19, 2013Date of Patent: November 8, 2016Assignee: Colorado School of MinesInventors: Keith B. Neeves, David W. M. Marr, Kevin B. Roth, Charles D. Eggleton
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Publication number: 20160263391Abstract: The invention relates to a magnetic-field driven colloidal microbot that employs wall-based propulsion, method of forming the microbot and a method of using the microbot. The microbot can be formed in situ with the use of magnetic fields, and the magnetic fields can be used to translate the microbot to a specified location in a patient. The microbot does not depend on “swimming” or flow currents within a patient to move, but instead can propel itself along a surface using a magnetic field. Once the magnetic field is removed, the microbot disassembles into colloidal particles.Type: ApplicationFiled: March 14, 2016Publication date: September 15, 2016Inventors: Tonguc Onur Tasci, Keith B. Neeves, David W.M. Marr
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Publication number: 20140366638Abstract: The present invention generally relates to a method for determining the dynamic viscoelastic properties of cells, more particularly to a method for rapidly determining the dynamic viscoelastic properties of healthy and unhealthy cells by determining the phase shift be the application of a modulating force to the cells and the cells' response to the modulating force.Type: ApplicationFiled: June 17, 2014Publication date: December 18, 2014Inventors: Tobias Sawetzki, David W.M. Marr, Charles Eggleton, Sanjay Desai
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Publication number: 20130230879Abstract: A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel, each of which are carrying one or more objects. There is an intersection between the first and second microfluidic channels where one or more objects from the first microfluidic channel impact one or more objects from the second microfluidic channel under hydrodynamic forces. The impact causes the objects to deform and the deformation of objects can be analyzed to determine properties of the object.Type: ApplicationFiled: February 19, 2013Publication date: September 5, 2013Applicant: COLORADO SCHOOL OF MINESInventors: Keith B. Neeves, David W.M. Marr, Kevin B. Roth, Charles D. Eggleton
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Patent number: 8119976Abstract: A system, method, and device for re-orienting and/or deforming cells and other objects is provided. The system, method, and device may include a high-throughput setup that facilitates the ability to orient, deform, analyze, measure, and/or tag objects at a substantially higher rate than was previously possible. A relatively large number of cells and other objects can be deformed, by optical forces for example, as the cells and other objects a flowed through the system.Type: GrantFiled: July 2, 2008Date of Patent: February 21, 2012Assignee: Colorado School of MinesInventors: Jeff Squier, David W. M. Marr, Robert Applegate, Tor Vestad, Justin Chichester
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Patent number: 7704320Abstract: The methods provided use external fields such as light and electricity as a means of directing the crystallization of concentrated colloidal systems. Not only can nucleation be directed, crystal melting can be carefully controlled and light-induced crystal diffraction used as a means of directing light propagation. A number of factors play a significant role on the crystallization rate and location, including the intensity of the light field, the magnitude of the electric field, the colloid concentration, the colloid size, and the colloid composition. In varying these parameters, kinetics in these processes are extremely fast when compared to traditional colloidal crystallization approaches.Type: GrantFiled: May 3, 2004Date of Patent: April 27, 2010Assignee: Colorado School of MinesInventors: David W. M. Marr, Tieying Gong, David Wu
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Publication number: 20090188795Abstract: A system, method and apparatus employing the laminar nature of fluid flows in microfluidic flow devices in separating, sorting or filtering colloidal and/or cellular particles from a suspension in a microfluidic flow device is disclosed. The microfluidic flow device provides for separating a particle within a suspension flow in a microfluidic flow chamber. The chamber includes a microfluidic channel comprising at least one inlet port for receiving a suspension flow under laminar conditions, a first outlet port and a second outlet port. The chamber further includes an interface for translating a particle within the channel. The first outlet port receives a first portion of the suspension exiting the said channel and the second outlet port receives the particle in a second portion of the suspension exiting the channel.Type: ApplicationFiled: November 25, 2008Publication date: July 30, 2009Applicant: Colorado School of MinesInventors: John Oakey, David W.M. Marr
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Publication number: 20090110010Abstract: The direct integration of light and optical control into microfluidic systems presents a significant hurdle to the development of portable optical trapping-based devices. A simple, inexpensive fiber-based approach is provided that allows for easy implementation of diode-bars for optical particle separations within flowing microfluidic systems. Models have also been developed that demonstrate the advantages of manipulating particles within flow using linear geometries as opposed to individually focused point traps as traditionally employed in optical-trapping micromanipulation.Type: ApplicationFiled: September 26, 2008Publication date: April 30, 2009Applicant: COLORADO SCHOOL OF MINESInventors: Jeff Squier, David W.M. Marr, Robert Applegate, Tor Vestad
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Publication number: 20090062828Abstract: Methods, devices, and systems for performing a non-invasive form of angioplasty are provided. The device may include one or many magnetically controlled colloidal particles that can be used to scrub the interior walls of arteries or the like. The colloidal particles may be organized in any number of configurations and may also be moved in any number of ways in an effort to maximize the amount of plaque removed from the artery.Type: ApplicationFiled: September 3, 2008Publication date: March 5, 2009Applicant: COLORADO SCHOOL OF MINESInventor: David W.M. Marr
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Publication number: 20090026387Abstract: A system, method, and device for re-orienting and/or deforming cells and other objects is provided. The system, method, and device may include a high-throughput setup that facilitates the ability to orient, deform, analyze, measure, and/or tag objects at a substantially higher rate than was previously possible. A relatively large number of cells and other objects can be deformed, by optical forces for example, as the cells and other objects a flowed through the system.Type: ApplicationFiled: July 2, 2008Publication date: January 29, 2009Applicant: COLORADO SCHOOL OF MINESInventors: Jeff Squier, David W.M. Marr, Robert Applegate, Tor Vestad, Justin Chichester
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Patent number: 7472794Abstract: A system, method and apparatus employing the laminar nature of fluid flows in microfluidic flow devices in separating, sorting or filtering colloidal and/or cellular particles from a suspension in a microfluidic flow device is disclosed. The microfluidic flow device provides for separating a particle within a suspension flow in a microfluidic flow chamber. The chamber includes a microfluidic channel comprising at least one inlet port for receiving a suspension flow under laminar conditions, a first outlet port and a second outlet port. The chamber further includes an interface for translating a particle within the channel. The first outlet port receives a first portion of the suspension exiting the said channel and the second outlet port receives the particle in a second portion of the suspension exiting the channel.Type: GrantFiled: February 14, 2007Date of Patent: January 6, 2009Assignee: Colorado School of MinesInventors: John Oakey, David W. M. Marr
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Patent number: 7318902Abstract: A system, method and apparatus employing the laminar nature of fluid flows in microfluidic flow devices in separating, sorting or filtering colloidal and/or cellular particles from a suspension in a microfluidic flow device is disclosed. The microfluidic flow device provides for separating a particle within a suspension flow in a microfluidic flow chamber. The chamber includes a microfluidic channel comprising at least one inlet port for receiving a suspension flow under laminar conditions, a first outlet port and a second outlet port. The chamber further includes an interface for translating a particle within the channel. The first outlet port receives a first portion of the suspension exiting the said channel and the second outlet port receives the particle in a second portion of the suspension exiting the channel.Type: GrantFiled: February 4, 2003Date of Patent: January 15, 2008Assignee: Colorado School of MinesInventors: John Oakey, David W. M. Marr
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Patent number: 7276170Abstract: A system, method and apparatus employing the laminar nature of fluid flows in microfluidic flow devices in separating, sorting or filtering colloidal and/or cellular particles from a suspension in a microfluidic flow device is disclosed. The microfluidic flow device provides for separating a particle within a suspension flow in a microfluidic flow chamber. The chamber includes a microfluidic channel comprising at least one inlet port for receiving a suspension flow under laminar conditions, a first outlet port and a second outlet port. The chamber further includes an interface for translating a particle within the channel. The first outlet port receives a first portion of the suspension exiting the said channel and the second outlet port receives the particle in a second portion of the suspension exiting the channel.Type: GrantFiled: March 30, 2006Date of Patent: October 2, 2007Assignee: Colorado School of MinesInventors: John Oakey, David W. M. Marr
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Patent number: 7155082Abstract: The present invention provides microfluidic optical waveguides and waveguide switches providing capability for multiple outlet paths for the fluid waveguides and optical signals contained therein. A microfluidic structure comprises a core inlet channel, one or more cladding fluid inlet channels intersecting with the core inlet channel downstream of a core inlet, and at least two outlet channels coupled to the core inlet channel and downstream of the cladding fluid channel. An optical source providing an optical signal is aligned with the core inlet channel. A waveguiding fluid is supplied to the core inlet channel and a cladding fluid supplied to each of the cladding channels. The waveguiding fluid and cladding fluid form an optical waveguide operable to transmit the optical signal. The flow rate of the cladding fluid is selectable to switch the optical waveguide between at least the first and second outlet channels.Type: GrantFiled: April 12, 2005Date of Patent: December 26, 2006Assignee: Colorado School of MinesInventors: John Oakey, David W. M. Marr
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Patent number: 6802489Abstract: The present invention relates to the use colloidal particles to realize photonic and microfluidic devices. In particular embodiments, colloidal particles are used to realize microfluidic a two-way valve, three-way valve, check valve, three-dimensional valve, peristalsis pump, rotary pump, vane pump, and two-lobe gear pump. In certain embodiments, actuation of an active element in the microfluidic structure is accomplished by electrophoresis, the use of an optical trap or “tweezer”, or the application of an electric field or magnetic field. In other embodiments, the application of an electrical field to colloidal particles that are substantially constrained to two dimensional movement is used to realize wave guides, filters and switches for optical signals.Type: GrantFiled: May 3, 2002Date of Patent: October 12, 2004Assignee: Colorado School of MinesInventors: David W. M. Marr, Tieying Gong, John Oakey, Alexander V. Terray
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Publication number: 20030159999Abstract: A system, method and apparatus employing the laminar nature of fluid flows in microfluidic flow devices in separating, sorting or filtering colloidal and/or cellular particles from a suspension in a microfluidic flow device is disclosed. The microfluidic flow device provides for separating a particle within a suspension flow in a microfluidic flow chamber. The chamber includes a microfluidic channel comprising at least one inlet port for receiving a suspension flow under laminar conditions, a first outlet port and a second outlet port. The chamber further includes an interface for translating a particle within the channel. The first outlet port receives a first portion of the suspension exiting the said channel and the second outlet port receives the particle in a second portion of the suspension exiting the channel.Type: ApplicationFiled: February 4, 2003Publication date: August 28, 2003Inventors: John Oakey, David W.M. Marr
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Publication number: 20030012657Abstract: The present invention relates to the use colloidal particles to realize photonic and microfluidic devices. In particular embodiments, colloidal particles are used to realize microfluidic a two-way valve, three-way valve, check valve, three-dimensional valve, peristalsis pump, rotary pump, vane pump, and two-lobe gear pump. In certain embodiments, actuation of an active element in the microfluidic structure is accomplished by electrophoresis, the use of an optical trap or “tweezer”, or the application of an electric field or magnetic field. In other embodiments, the application of an electrical field to colloidal particles that are substantially constrained to two dimensional movement is used to realize wave guides, filters and switches for optical signals.Type: ApplicationFiled: May 3, 2002Publication date: January 16, 2003Inventors: David W.M. Marr, Tieying Gong, John Oakey, Alexander V. Terray