Abstract: Provided herein are phosphodiesterase 4 (PDE4) degraders, e.g., a compound of Formula (I) or (IA), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a PDE4-mediated disease, disorder, or condition.

Abstract: A very high density storage system comprising a storage grid having a number of storage cells and individual cargo carriers where a cargo carrier is stored in a storage cell. The storage system uses a unique set of individually actuatable gear drives on both the top and bottom of each storage cell, but installed at 90 degrees to each other, to move the cargo carrier to a specific storage cell. Software controls and manages the location of each cargo carrier such that when a specific cargo carrier is desired, software instructions cause the cargo carriers to be shuffled within the storage grid until the desired cargo carrier is located at the desired position, such as an unloading position.

Abstract: A very high density storage system comprising a storage grid having a number of storage cells and individual cargo carriers where a cargo carrier is stored in a storage cell. The storage system uses a unique set of individually actuatable gear drives on both the top and bottom of each storage cell, but installed at 90 degrees to each other, to move the cargo carrier to a specific storage cell. Software controls and manages the location of each cargo carrier such that when a specific cargo carrier is desired, software instructions cause the cargo carriers to be shuffled within the storage grid until the desired cargo carrier is located at the desired position, such as an unloading position.

Abstract: A bipropellant gun in which an immiscible hydrocarbon fuel and oxidizer are combined in the gun's combustion chamber just prior to, or simultaneous with, ignition thereof. The oxidizer consists of hydrogen peroxide having a concentration of less than 73 percent by weight. In one embodiment, the oxidizer alone is bulk loaded into the combustion chamber and a powdered solid hydrocarbon fuel is dispersed into the oxidizer by the function of a pyrotechnic igniter. In another embodiment, the oxidizer and a liquid hydrocarbon are emulsified and the emulsion is bulk loaded into the combustion chamber with a pyrotechnic igniter subsequently initiating combustion. In each embodiment, the volume of the combustion chamber exceeds the volume of fuel and oxidizer and provides a void or headspace of compressible gas which limits the rate of pressure rise in the chamber.