Abstract: Embodiments disclosed herein relate to measuring thermal properties. At least one embodiment includes a method including heating a location of an object with an excitation laser beam, the excitation laser beam being a continuous-wave laser beam modulated by a square-wave modulation waveform. The method may also include measuring temperature at the location over time by measuring changes in one or more reflective properties at the location. Related apparatuses are also disclosed.

Abstract: A method includes receiving a training dataset that includes one or more spoken training utterances for training an automatic speech recognition (ASR) model. Each spoken training utterance in the training dataset paired with a corresponding transcription and a corresponding target sequence of auxiliary tokens. For each spoken training utterance, the method includes generating a speech recognition hypothesis for a corresponding spoken training utterance, determining a speech recognition loss based on the speech recognition hypothesis and the corresponding transcription, generating a predicted auxiliary token for the corresponding spoken training utterance, and determining an auxiliary task loss based on the predicted auxiliary token and the corresponding target sequence of auxiliary tokens. The method also includes the ASR model jointly on the speech recognition loss and the auxiliary task loss determined for each spoken training utterance.

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: An indexed sequence of bits in a buffer is allocated for tracking a battery charging state. The indexed sequence of bits has a first number of bits. A battery voltage of a rechargeable battery is sampled at a sampling rate. For each sampled battery voltage, the battery voltage is compared with a voltage threshold. A next bit position in the indexed sequence of bits is identified. In accordance with a determination that a comparison result is true, a predefined first value is added to the next bit position. A second number of bits that are filled with the predefined first value is determined. A ratio between the second number and the first number is also determined. In accordance with a determination that the ratio exceeds a threshold step-down ratio, a battery charge voltage is stepped down. The rechargeable battery is charged to a step-down voltage.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: A honeycomb body having a repeating channel structure formed of intersecting porous walls. The repeating channel structure comprises a first channel type defined by at least four first surfaces, at least two of the at least four first surfaces are parallel to one another; and a second channel type having at least four second surfaces, wherein four or more of the at least four second surfaces are non-parallel with one another. Repeating channel structure is repeated in the honeycomb body. Honeycomb extrusion dies and methods of manufacturing the honeycomb body are provided, as are other embodiments.

Abstract: The present application provides bicyclic amines of Formula (I): and their pharmaceutically acceptable salts thereof, that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: Embodiments of the disclosed technologies receive first event data associated with a first party application, receive second event data representing a click, in the first party application, on a link to a third party application, receive third event data from the third party application, convert the third event data to a label, map a compressed format of the labeled third event data to the first event data and the second event data to create multi-party attribution data, group multiple instances of the multi-party attribution data into a batch, add noise to the compressed format of the labeled third event data in the batch, and send the noisy batch to a second computing device. A debiasing algorithm can be applied to the noisy batch. The debiased noisy batch can be used to train at least one machine learning model.

Abstract: Systems and methods for reconciling location based on multiple computing device signals. For example, the computing system can obtain location datasets associated with freight carrier services from computing sources. The computing system can determine an expected signal pattern for a location associated with a freight transportation service. The computing system can determine, for each computing source, a confidence score. The confidence score can represent the probability that the respective location dataset is associated with a load being transported for a freight transportation service. The computing system can determine a primary location dataset based on the confidence scores. The computing system can perform actions based on the primary location dataset.

Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: A process includes accessing a first message that is sent from an access point device. The first message includes data representing a second message that is sent by a client device. The second message is part of an exchange of messages between the client device and the access point device associated with authentication of the client device and a derivation of a first key used to encrypt and decrypt data communicated between the client device and the access point device. The second message includes a first message integrity check value. The process includes identifying, based on the second message, a pre-shared key corresponding to the client device.

Abstract: The disclosed embodiments disclose techniques for performing universal post-training backdoor detection and mitigation for classifiers. Mitigation of overfitting for a trained classifier begins with receiving the trained classifier and a clean dataset that spans a plurality of classes for the trained classifier. A set of input patterns are used to calculate classification margins for the trained classifier, and maximum classification margins are calculated for one or more classes of the trained classifier. Overfitting can then be mitigated by reducing one or more of these calculated maximum classification margins while maintaining the accuracy of the trained classifier for the clean dataset. In some embodiments, a backdoor detector may also detect target classes for a putative backdoor in the trained classifier upon detecting that the corresponding maximum classification margins for those target classes are anomalously high compared to the maximum classification margins of other classes.

Abstract: Embodiments of the present disclosure generally relate to a substrate support having a surface coating which reduces defect formation and back side metal contamination during substrate processing. A support body includes a body having an outer surface and a surface coating formed from a non-metal or a reduced-metal material disposed over at least a top surface of the outer surface of the body. In an embodiment, the surface coating includes a two-part coating having an optional first coating layer formed over an entire outer surface of the support body.

Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

Abstract: This application describes systems and methods for generating machine learning models (MLMs). An exemplary method includes obtaining a sample and user input data characterizing a product or service. A subset of the data is selected from the sample based on sampling the sample according to the user input data. An MLM is trained by applying the data subset as training input to the MLM, thereby providing a trained MLM to emulate a customer selection process unique to the product or service. A user interface (UI) configured to receive other user input data and cause the trained MLM to execute on the other user input data, thereby testing the trained MLM, is presented. A summary of results from the execution of the trained MLM is generated and presented in the UI. The summary of results indicates a contribution to the trained MLM of each of a plurality of features.

Abstract: A system for visualization and quantification of ultrasound imaging data according to embodiments of the present disclosure may include a display unit, and a processor communicatively coupled to the display unit and to an ultrasound imaging apparatus for generating an image from ultrasound data representative of a bodily structure and fluid flowing within the bodily structure. The processor may be configured to estimate axial and lateral velocity components of the fluid flowing within the bodily structure, determine a plurality of flow directions within the image based on the axial and lateral velocity components, differentially encode the flow directions based on flow direction angle to generate a flow direction map, and cause the display unit to concurrently display the image including the bodily structure overlaid with the flow direction map.

Abstract: A wireless communication network receives a first Subscriber Identity Module (SIM) profile from a User Equipment (UE) and authenticates the UE based on the first SIM profile. The network receives a first slice request from the UE and authorizes a first wireless network slice for the UE based on the authentication of the first SIM profile and the first slice request. The network receives a second SIM profile from the UE and authenticates the UE based on the second SIM profile. The network receives a second slice request from the UE and authorizes a second wireless network slice for the UE based on the authentication of the second SIM profile and the second slice request. The network wirelessly exchanges first slice data with the UE over the first wireless network slice, and simultaneously, exchanges second slice data with the UE over the second wireless network slice.

Abstract: Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.