Abstract: Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X is O, D, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Abstract: In one example, a controller device for a software defined network (SDN) includes one or more network interfaces configured to communicate with network devices of the SDN, and one or more processors configured to obtain data representative of the network devices in the SDN, instantiate software-based controller objects for controllers of the network devices, instantiate software-based switch description objects for switches of the network devices, wherein the software-based switch description objects each comprise data representative of a respective primary controller corresponding to a controller of the one or more controllers, a respective switch identifier, a respective switch media access control (MAC) address, a respective Internet protocol (IP) address, and a respective array of port description objects for each physical port on the respective switch, and managing, via the network interfaces, at least some of the switches using the switch description objects and the controller objects.

Abstract: In one example, a controller device for a software defined network (SDN) includes one or more network interfaces configured to communicate with network devices of the SDN, and one or more processors configured to determine a primary path for network traffic between network devices of the SDN, determine a backup path to the primary path for the network traffic between the network devices of the SDN, and, in response to a failover event, configure the network devices to switch from the primary path to the backup path.

Abstract: In one example, a controller device for a software defined network (SDN) includes one or more interfaces for communicating with network devices in the software defined network, and one or more processors configured to determine connections between the network devices, determine one or more paths for network traffic between the network devices based on the determination of the connections, and program the network devices to direct network traffic along the one or more paths.