Abstract: This disclosure relates to a method of using an adjustable tibial sizer for use in knee arthroplasty. The sizer includes a two-part body comprising: a first body portion, a second body portion, and a connection element extending therebetween.

Abstract: An apparatus and methods for guiding the orientation of an item of surgical equipment relative to a limb of a patient are described. A reference orientation sensor and a surgical equipment orientation sensor may be included. A data processing apparatus determines and stores an initial relative orientation between the reference orientation sensor and the surgical equipment orientation sensor from an initial reference orientation and an initial surgical equipment orientation, determines a current relative orientation between the reference orientation sensor and the surgical equipment sensor from a current reference orientation and a current surgical equipment orientation, and generates an output signal when the current relative orientation matches the reference relative orientation indicating that the surgical equipment orientation sensor currently has the same orientation relative to the reference orientation sensor as when the initial relative orientation was determined.

Abstract: A unicondylar posterior cutting block, method of use and kit of surgical components are provided, with the cutting block comprising: a base which is mountable on a resected proximal tibial surface of a knee of a patient in use; and a body pivotally attached to the base, the body including an alignment formation arranged to align with a marking on a femur in use, the body defining a cutting guide therein for receiving a cutting instrument to make a unicondylar posterior cut in the femur and wherein moving the alignment formation to align with the marking on the femur causes the body to rotate relative to the base and to tilt the cutting guide relative to the base. Different bases offer different cut positions and rotation of the base offers further different cut positions.

Abstract: This disclosure relates to an adjustable tibial sizer for use in knee arthroplasty, the sizer includes a two-part body comprising: a first body portion, a second body portion, and a connection element extending therebetween. Each of the first and second body portions includes a ramp surface configured for simultaneous movement of the first body portion relative to the second body portion in an anterior-posterior direction and a medial-lateral direction, and method of use thereof.

Abstract: A surgical planning method carried out by a data processing apparatus that comprises determining a lateral force-distance characteristic for each of a plurality of knee flexion angles, determining a medial force-distance characteristic for each of the plurality of knee flexion angles, using a lateral force-distance characteristic to determine a lateral knee gap distance corresponding to a target force for at least one of the plurality of knee flexion angles, and using a medial force-displacement characteristic to determine a medial knee gap distance corresponding to a target force for at least one of the plurality of knee flexion angles. The method also comprises outputting the lateral knee gap distance corresponding to the target force and the medial knee gap distance corresponding to the target force as a function of knee flexion angle.

Abstract: This disclosure relates to an adjustable tibial sizer for use in knee arthroplasty, the sizer includes a two-part body comprising: a first body portion, a second body portion, and a connection element extending therebetween. Each of the first and second body portions includes a ramp surface configured for simultaneous movement of the first body portion relative to the second body portion in an anterior-posterior direction and a medial-lateral direction, and method of use thereof.

Abstract: Embodiments of the present disclosure relate generally to expression of synthetic messenger RNA (mRNA) in target cells (e.g., a cardiac cell, such as for example and not limitation, a cardiomyocyte, a neuronal cell, a cell located within the eye, a pancreatic cell, a PSC, an IPSC, an ESC, and/or a PSC cardiomyocyte) in order to modulate and/or detect cell phenotype, and more specifically to use of a composition comprising (i) at least one (or a combination of) mRNA(s) encoding a differentiation factor, a transcription factor and/or a phenotype sensor; and (ii) a delivery vehicle, such as for example and not limitation, a cationic lipid, a polyethylenimine (PEI) derivative, a polymer, a polypeptide or peptide, a nanoparticle, or a lipid-based particle, wherein the composition is delivered to the target cell.

Abstract: A femoral component (2) of a knee joint prosthesis has a bearing surface (4) for articulation with a tibial bearing surface and an opposite bone facing surface (6). The bone facing surface has anterior (18), posterior (20), distal (22), anterior chamfer (24) and posterior chamfer (26) portions. Medial (42, 52, 356) and lateral rails (40, 50, 350) are provided on the distal portion or on at least one of the anterior chamfer portion and posterior chamfer portions of the bone facing surface so that there is at least one recess (46, 54, 354, 360) between the rails.

Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.

Abstract: A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibia tray 1006.

Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.

Abstract: A femoral component (2) of a knee joint prosthesis has a bearing surface (4) for articulation with a tibial bearing surface and an opposite bone facing surface (6). The bone facing surface has anterior (18), posterior (20), distal (22), anterior chamfer (24) and posterior chamfer (26) portions. Medial (42, 52, 356) and lateral rails (40, 50, 350) are provided on the distal portion or on at least one of the anterior chamfer portion and posterior chamfer portions of the bone facing surface so that there is at least one recess (46, 54, 354, 360) between the rails.

Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.

Abstract: A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibia tray 1006.

Abstract: A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibia tray 1006.

Abstract: A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibia tray 1006.

Abstract: A femoral component (2) of a knee joint prosthesis has a bearing surface (4) for articulation with a tibial bearing surface and an opposite bone facing surface (6). The bone facing surface has anterior (18), posterior (20), distal (22), anterior chamfer (24) and posterior chamfer (26) portions. Medial (42, 52, 356) and lateral rails (40, 50, 350) are provided on the distal portion or on at least one of the anterior chamfer portion and posterior chamfer portions of the bone facing surface so that there is at least one recess (46, 54, 354, 360) between the rails.

Abstract: A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibia tray 1006.

Abstract: A bearing component 2 for a joint replacement prosthesis comprises a first bearing element 4; a second bearing element 6, and a linking element 8, operatively connecting the first and second bearing elements 4, 6 and permitting relative motion there between. The flexible linking element 8 prevents dislocation of mobile bearings in a total knee replacement prosthesis. The invention also relates to a bridging element which retains the linking element 8 with some play, which acts as a ligament support 2051, and which causes a deflection of the line of action of a ligament 1018. A joint replacement prosthesis is also disclosed comprising a biasing element 1140 or a tensioning element 1220 operatively coupled to the artificial ligament 1018. The biasing element 1140 or tensioning element 1220 may be housed in the stem of a tibial tray 1006.

Abstract: A composition includes a plurality of coacervate micro and/or nanodroplets of oxidized alginate and a methacrylated gelatin.