Patents by Inventor David Yellowhair

David Yellowhair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel therapeutic delivery systems
    Publication number: 20100254904
    Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
    Type: Application
    Filed: August 1, 2006
    Publication date: October 7, 2010
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Therapeutic delivery systems
    Patent number: 7083572
    Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled liposomes having a drug encapsulated therein are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: August 1, 2006
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Methods of preparing gaseous precursor-filled microspheres
    Publication number: 20050163716
    Abstract: Methods of and apparatus for preparing gas-filled microspheres are described. Gas-filled microspheres prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Application
    Filed: January 14, 2005
    Publication date: July 28, 2005
    Inventors: Evan Unger, Thomas Fritz, Terry Matsunaga, Varadarajan Ramaswami, David Yellowhair, Guanli Wu
  • Container with multi-phase composition for use in diagnostic and therapeutic applications
    Patent number: 6551576
    Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: April 22, 2003
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Terry Matsunaga, David Yellowhair
  • Novel therapeutic delivery systems
    Publication number: 20030039613
    Abstract: Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided.
    Type: Application
    Filed: March 26, 2002
    Publication date: February 27, 2003
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Methods of preparing gaseous precursor-filled microspheres
    Publication number: 20030003055
    Abstract: Methods of and apparatus for preparing gas-filled microspheres are described. Gas-filled microspheres prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Application
    Filed: August 6, 2002
    Publication date: January 2, 2003
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Method of preparing gas and gaseous precursor-filled microspheres
    Patent number: 6479034
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: November 12, 2002
    Assignee: Bristol-Myers Squibb Medical Imaging, Inc.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Therapeutic delivery systems
    Patent number: 6443898
    Abstract: Therapeutic delivery systems comprising gaseous precursor-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Therapeutic delivery systems comprising gaseous precursor-filled liposomes having encapsulated therein a contrast agent or drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in therapeutic delivery applications are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 3, 2002
    Assignee: Imarx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Gas-filled lipid spheres for use in diagnostic and therapeutic applications
    Patent number: 6146657
    Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: November 14, 2000
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Terry Matsunaga, David Yellowhair
  • Targeted gas and gaseous precursor-filled liposomes
    Patent number: 6071495
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: June 6, 2000
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Apparatus for making gas-filled vesicles of optimal size
    Patent number: 6039557
    Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3.degree.. The total length of travel around the figure-8 pattern is at least 0.7 cm.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: March 21, 2000
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan Unger, Thomas McCreery, David Yellowhair, Terrence R. Barrette
  • Method of preparing fluorinated gas microspheres
    Patent number: 6033646
    Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: March 7, 2000
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Methods of preparing gas-filled liposomes
    Patent number: 5935553
    Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: August 10, 1999
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Methods of preparing gas and gaseous precursor-filled microspheres
    Patent number: 5853752
    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 29, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Method of preparing gas-filled microspheres using a lyophilized lipids
    Patent number: 5776429
    Abstract: Lyophilized lipid compositions, as well as methods for their preparation, are embodied by the present invention. Gas-filled microspheres prepared using the lyophilized lipid composition are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: July 7, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Container with multi-phase composition for use in diagnostic and therapeutic applications
    Patent number: 5773024
    Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: June 30, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Terry Matsunaga, David Yellowhair
  • Therapeutic drug delivery systems
    Patent number: 5770222
    Abstract: Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 23, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
    Patent number: 5733572
    Abstract: Gas and gaseous precursor filled microspheres, and foams thereof, provide novel topical and subcutaneous delivery vehicles for various active ingredients, including drugs and cosmetics.
    Type: Grant
    Filed: November 29, 1994
    Date of Patent: March 31, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Terry O. Matsunaga, David Yellowhair
  • Methods of preparing gas-filled liposomes
    Patent number: 5715824
    Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 10, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
  • Apparatus and method for making gas-filled vesicles of optimal size
    Patent number: 5656211
    Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3.degree.. The total length of travel around the figure-8 pattern is at least 0.7 cm.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 12, 1997
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan Unger, Thomas McCreery, David Yellowhair, Terrence R. Barrette