Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention relates to oral composition and the method of preparation and use of such composition for inhibiting, reducing, and/or disrupting oral biofilm. The composition comprises a stabilizing matrix, a cationic biocide, and a peroxide source.

Abstract: A system for measurement is provided. The system includes a first optical path configured to supply first light pulses with a first range of wavelengths; a second optical path configured to supply second light pulses with a second range of wavelengths shorter than the first range of wavelengths; an optical I/O unit configured to emit the first light pulses and the second light pulses to a target and acquire a light from the target to detect CARS light pluses from the target by a detector; and a first phase modulating unit configured to vary phase differences between the first light pulses and the second light pulses as the first light pulses and the second light pulses are emitted via the optical I/O unit.

Abstract: Systems and devices for cooling and dispensing a beverage fluid are disclosed herein. One beverage dispensing system includes a beverage tower comprising a tower body, a shank, and a faucet. In some implementations, a coolant line is routed proximal to a beverage supply line through the tower body, through the shank, and into the faucet. In these and other implementations, the faucet includes a removable nozzle having a supplemental portion of the coolant line. In these and still other implementations, the faucet include a removable nozzle having a second coolant line. The coolant line and the second coolant line are configured to transport a coolant medium proximal to a beverage fluid in the beverage supply line to maintain or adjust the temperature of the beverage fluid. Many other features are described herein.

Abstract: Provided are methods of preparing an electrochemically active cathode material including the steps of combining an alkali metal-containing nickel oxide having a formula A1?aNi1+aO2, wherein A comprises an alkali metal and 0<a?0.2, with a fluid composition including an oxidant comprising a peroxydisulfate salt, a monopersulfate salt, or a combination thereof to form a mixture, heating the mixture to a temperature of 50° C. or greater; and maintaining the mixture at the temperature for at least a period of time sufficient to form an alkali metal-deficient nickel oxide electrochemically active cathode material having a general formula AxHyNi1+aO2·nH2O, wherein A comprises an alkali metal; 0.08?x<0.2; 0?y<0.3; 0.02?a?0.2; and 0<n<2.

Abstract: Embodiments of the present disclosure provide a surgical robot system may include an end-effector element configured for controlled movement and positioning and tracking of surgical instruments and objects relative to an image of a patient's anatomical structure. In some embodiments the end-effector may be tracked by surgical robot system and displayed to a user. In some embodiments the end-effector element may be configured to restrict the movement of an instrument assembly in a guide tube. In some embodiments, the end-effector may contain structures to allow for magnetic coupling to a robot arm and/or wireless powering of the end-effector element. In some embodiments, tracking of a target anatomical structure and objects, both in a navigation space and an image space, may be provided by a dynamic reference base located at a position away from the target anatomical structure.

Abstract: Embodiments of the present disclosure relate to behavior planning for autonomous vehicles. The technology described herein selects a preferred trajectory for an autonomous vehicle based on an evaluation of multiple hypothetical trajectories by different components within a planning system. The various components provide an optimization score for each trajectory according to the priorities of the component and scores from multiple components may form a final optimization score. This scoring system allows the competing priorities (e.g., comfort, minimal travel time, fuel economy) of different components to be considered together. In examples, the trajectory with the best combined score may be selected for implementation. As such, an iterative approach that evaluates various factors may be used to identify an optimal or preferred trajectory for an autonomous vehicle when navigating an environment.

Abstract: Methods and materials for modulating low-nitrogen tolerance levels in plants are disclosed. For example, nucleic acids encoding low nitrogen tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased[RCL2] low-nitrogen tolerance levels and plant products produced from plants having increased low-nitrogen tolerance levels.

Abstract: Systems and methods for incident response using artificial intelligence for information technology operations are disclosed. In one embodiment, a method may include an incident response computer program executed by an electronic device: (1) receiving an incident ticket for an incident involving a computer product or a computer system within an organization from a service management platform for the computer product or the computer system; (2) providing incident information from the incident ticket to a trained incident response machine learning engine, wherein the trained incident response machine learning engine is trained to predict a solution for the incident based on historical incident data; (3) receiving, from the trained incident response machine learning engine, a predicted solution for the incident; and (4) providing the predicted solution to the service management platform. The service management platform provides the predicted solution to the computer product or the computer system.

Abstract: A method includes: creating a training data set based on user input, the training data set including time series data of a price of an asset and stochastic event data of events related to the asset; creating an event intensity model that models an event intensity parameter of one of the events related to the asset, wherein the event intensity model comprises a proximal graphical event model (PGEM), and the creating the event intensity model includes learning parameters of the PGEM using machine learning and the training data set; creating a probabilistic time series model that predicts a probability distribution of a return of the asset, wherein the creating the probabilistic time series model includes learning parameters of the probabilistic time series model using machine learning and the training data set; and predicting a future return of the asset for a future time period using the probabilistic time series model.

Abstract: Devices, systems and methods for detecting a position of an object with a robot surgical system having an articulable, separable camera stand. The surgical robot system may include a robot having a robot base with a robot arm and an end-effector coupled to the robot arm. The end-effector, surgical instruments, the patient, other objects, or any combination thereof, may be tracked via active and/or passive tracking markers. A camera, such as an infrared camera, a bifocal camera or a stereophotogrammetric infrared camera, is mounted on a separable camera stand and is able to detect the tracking markers when in use. Using the camera, the robot determines a position of the object from the tracking markers, which may be a three-dimensional position of the object or the markers. When convenient, the camera base may be assembled into the robot base, e.g., by sliding the camera base into the robot.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: Processing chambers including at least one gas reservoir connected to and in fluid communication with the lid through a fast-switching valve and a gas reservoir line are described. Processing methods, for example, etching methods, using the processing chambers are also described.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A method includes receiving a training dataset that includes one or more spoken training utterances for training an automatic speech recognition (ASR) model. Each spoken training utterance in the training dataset paired with a corresponding transcription and a corresponding target sequence of auxiliary tokens. For each spoken training utterance, the method includes generating a speech recognition hypothesis for a corresponding spoken training utterance, determining a speech recognition loss based on the speech recognition hypothesis and the corresponding transcription, generating a predicted auxiliary token for the corresponding spoken training utterance, and determining an auxiliary task loss based on the predicted auxiliary token and the corresponding target sequence of auxiliary tokens. The method also includes the ASR model jointly on the speech recognition loss and the auxiliary task loss determined for each spoken training utterance.

Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: Apparatus include a first laser diode situated to emit a beam from an exit facet along an optical axis, the beam as emitted having perpendicular fast and slow axes perpendicular to the optical axis, a first fast axis collimator (FAC) optically coupled to the beam as emitted from the exit facet and configured to direct the beam along a redirected beam axis having a non-zero angle with respect to the optical axis of the first laser diode, a second laser diode situated to emit a beam from an exit facet of the second laser diode along an optical axis parallel to the optical axis of the first laser diode and with a slow axis in a common plane with the slow axis of the first laser diode, and a second fast axis collimator (FAC) optically coupled to the beam as emitted from the exit facet of the second laser diode and configured to direct the beam along a redirected beam axis having a non-zero angle with respect to the optical axis of the second laser diode.

Abstract: Disclosed are biomarkers, methods and assay systems for the identification of poor prognosis of interstitial pneumonia (pulmonary fibrosis) in an individual diagnosed with suspected of having interstitial pneumonia.

Abstract: A controller of a chemical mechanical polishing system is configured to cause a carrier head to sweep across a polishing pad in accord with a sweep profile. The controller is also configured to select values for a plurality of control parameters to minimize a difference between a target removal profile and an expected removal profile. The plurality of control parameters include a plurality of dwell time parameters. A relationship between the plurality of control parameters and a removal rate is stored in a data structure representing a first matrix which includes a plurality of columns including a column for each dwell time parameter and a row for each position on the substrate represented in the expected removal profile, and the controller is configured to, as part of selection of the values, calculate the expected removal profile by multiplying the first matrix by a second matrix representing control parameter values.

Abstract: A method of operating an engine includes operating the engine in first and second engine operating map regions by performing passive jet ignition combustion with a first stoichiometric fuel mixture and a first volume of residual gas. The engine is operated in a third engine operating map region by performing turbulent jet controlled compression ignition (TJCCI) with an ultra lean fuel mixture and a first volume of cooled exhaust gas recirculation, a fourth engine operating map region by performing passive jet ignition combustion with a third stoichiometric fuel mixture and a second volume of cooled exhaust gas recirculation, and a fifth engine operating map region, characterized by shutting off the engine. The engine is operated in a mode transition region between the second, third, and fourth engine operating map regions by performing passive jet ignition combustion with a second stoichiometric fuel mixture and a second volume of residual gas.