Abstract: Unsupervised cross-domain data augmentation techniques for long-text document based prediction and explanation are provided. In one aspect, a system for long-document based prediction includes: an encoder for creating embeddings of long-document texts with hierarchical sparse self-attention, and making predictions using the embeddings of the long-document texts; and a multi-source counterfactual augmentation module for generating perturbed long-document texts using unlabeled sentences from at least one external source to train the encoder. A method for long-document based prediction is also provided.

Abstract: Methods and systems are disclosed for determining sensor degradation by actively controlling an autonomous vehicle. Determining sensor degradation may include obtaining sensor readings from a sensor of an autonomous vehicle, and determining baseline state information from the obtained sensor readings. A movement characteristic of the autonomous vehicle, such as speed or position, may then be changed. The sensor may then obtain additional sensor readings, and second state information may be determined from these additional sensor readings. Expected state information may be determined from the baseline state information and the change in the movement characteristic of the autonomous vehicle. A comparison of the expected state information and the second state information may then be performed. Based on this comparison, a determination may be made as to whether the sensor has degraded.

Abstract: Disclosed herein is a stellarator comprising two sets of coils, namely a set of encircling coils which encircle the plasma axis, and a set of shaping coils which do not encircle any other coil or the plasma. In some embodiments, the encircling coils include a structural element to maintain their shape under magnetic forces. In some embodiments, the shaping coils are mounted onto one or more structural elements which, together with the shaping coils, constitute a field shaping unit. Also disclosed is a controller which may modify the electrical current flowing in one or more subsets of the coils in order to achieve target plasma parameters. Also disclosed is a method of designing a set of shaping coils by discretizing a surface dipole or current potential distribution.

Abstract: A method of producing a polyether alcohol that includes feeding an initiator into a reactor, feeding one or more monomers into the reactor, feeding a polymerization catalyst into the reactor, the polymerization catalyst being a Lewis acid catalyst having a general formula M(R1)1(R2)1(R3)1(R4)0 or 1, separate from feeding the initiator into the reactor, feeding a hydrogen bond acceptor additive into the reactor, the hydrogen bond acceptor additive being a C2 to C20 organic molecule having at least two hydroxyl groups, of which two hydroxyl groups are situated in 1,2-, 1,3-, or 1,4-positions on the organic molecule, and allowing the initiator to react with the one or more monomers in the presence of the polymerization catalyst and the hydrogen bond acceptor additive to form a polyether alcohol having a number average molecular weight greater than a number average molecular weight of the initiator.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: A graph with a plurality of nodes, a plurality of edges, and a plurality of node features is obtained and node representations for the node features are generated. A plurality of structure learning scores is generated based on the node representations, each structure learning score corresponding to one of the plurality of edges. A subset of the plurality of edges that identify a subgraph is selected, each edge of the subset having a structure learning score that is greater than a given threshold. The subgraph is inputted to a representation learner and an inferencing operation is performed using the representation learner based on the subgraph.

Abstract: A method includes: creating a training data set based on user input, the training data set including time series data of a price of an asset and stochastic event data of events related to the asset; creating an event intensity model that models an event intensity parameter of one of the events, wherein the event intensity model is based on a multivariate Hawkes process, and the creating the event intensity model includes learning parameters of the event intensity model using machine learning and the training data set; creating a probabilistic time series model that predicts a probability distribution of a return of the asset, wherein the creating the probabilistic time series model includes learning parameters of the probabilistic time series model using machine learning and the training data set; and predicting a future return of the asset for a future time period using the probabilistic time series model.

Abstract: A method includes: creating a training data set based on user input, the training data set including time series data of a price of an asset and stochastic event data of events related to the asset; creating an event intensity model that models an event intensity parameter of one of the events related to the asset, wherein the event intensity model comprises a proximal graphical event model (PGEM), and the creating the event intensity model includes learning parameters of the PGEM using machine learning and the training data set; creating a probabilistic time series model that predicts a probability distribution of a return of the asset, wherein the creating the probabilistic time series model includes learning parameters of the probabilistic time series model using machine learning and the training data set; and predicting a future return of the asset for a future time period using the probabilistic time series model.

Abstract: The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.

Abstract: A generation identifier is employed with various systems and methods in order to identify situations where a workload has been reassigned to a new node and where a workload is still being processed by an old node during a failure between nodes. A master node may assign a workload to a worker node. The worker node sends a request to access target data. The request may be associated with a generation identifier and workload identifier that identifies the node and workload. At some point, a failure occurs between the master node and worker node. The master node reassigns the workload to another worker node. The new worker node accesses the target data with a different generation identifier, indicating to the storage system that the workload has been reassigned. The old worker node receives an indication from the storage system that the workload has been reassigned and stops processing the workload.

Abstract: The present disclosure relates to a carrier for sustained-release of a drug and use thereof. The carrier is used to carry a drug. The carrier is in a gel state, a semi-solid state, or a solid state. The carrier includes a polyol fatty acid ester as a main component and a hydrogenated vegetable oil dissolved in the polyol fatty acid ester. The state of the sustained-release carrier can be adjusted by adjusting the amount of the dissolved hydrogenated vegetable oil.

Abstract: The present disclosure provides compositions and methods useful for inducing an immune response and overcoming immune tolerance in a subject suffering from Hepatitis B. As described herein, the compositions of the disclosure comprise HBsAg having S, Pre-S1 and Pre-S2 proteins, an aluminum phosphate adjuvant and interferon-?.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: A control device for controlling a temperature of a laser device includes a pulse width modulation (PWM) signal generator, a temperature acquisition circuit, a voltage comparator, and a logic circuit. The a pulse width modulation (PWM) signal generator configured to generate a PWM signal; a temperature acquisition circuit configured to acquire a temperature of the laser device and convert the temperature into a measurement voltage; a voltage comparator configured to compare the acquired measurement voltage associated with the temperature of the laser device with a temperature threshold voltage and output a comparison result signal; and a logic circuit configured to generate a drive signal based on the PWM signal and the comparison result signal to drive the laser device.

Abstract: The disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.

Abstract: Remote automated assistant component(s) generate client device notification(s) based on a received IoT state change notification that indicates a change in at least one state associated with at least one IoT device. The generated client device notification(s) can each indicate the change in state associated with the at least one IoT device, and can optionally indicate the at least one IoT device. Further, the remote automated assistant component(s) can identify candidate assistant client devices that are associated with the at least one IoT device, and determine whether each of the one or more of the candidate assistant client device(s) should render a corresponding client device notification.

Abstract: A composition, a gas diffusion electrode, and a method for fabricating the same is disclosed. In an example, the composition includes carbon supported carboxyl surface functionalized silver nanoparticles. The gas diffusion electrode can be fabricated with the carbon supported carboxyl surface functionalized silver nanoparticles and deployed in a membrane electrode assembly for various applications.

Abstract: A Method and System for coordinating help to an individual experiencing a medical emergency from their designated Emergency Care Team (ECT). The location of the Person in Distress (PID) and all of their emergency contacts is determined. A real time audio video conference is created which enables the PID and all members of the ECT to communicate. Real time vital signs from the PID's wearable health monitor is streamed to all participants. The PID's medical history is temporarily unlocked and provided on demand to the ECT members. The ECT members participate as available with no single person or call center coordinating this effort. Additional participants may be added to the conference at the discretion of the ECT members including, but not limited to the E911 operator for the PID's locale, the PID's medical providers, other individuals from the PID's contact list, or other individuals as may be deemed important to the response.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: The present invention relates to inkjet ink compositions that take advantage of solvent mixtures containing an ester, a ketone, and optionally an alcohol, in order to provide ink compositions that have suitable qualities for inkjet printing. Preferred ink compositions include a C1-C3 alkyl ester of C1-C3 carboxylic acid, a C3-C7 ketone, and optionally a C2-C3 alkyl alcohol.