Patents by Inventor Daxian Shan

Daxian Shan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LOW PH PHARMACEUTICAL ANTIBODY FORMULATION
    Publication number: 20210047407
    Abstract: The present disclosure describes low pH formulations comprising, e.g., an antigen-binding protein that binds CD3, at least one buffer agent, at least one saccharide and at least one surfactant.
    Type: Application
    Filed: February 8, 2019
    Publication date: February 18, 2021
    Inventors: Twinkle R. Christian, Daxian Shan
  • Peptide sustained release compositions and uses thereof
    Publication number: 20080095849
    Abstract: Sustained delivery compositions that modulate the release of incorporated prophylactic, therapeutic, and/or diagnostic agents, and methods of preparation and use thereof, are disclosed. In particular embodiments, the compositions include a polymeric matrix; a prophylactic, therapeutic, and/or diagnostic agent dispersed and/or dissolved within the polymeric matrix; and a carbohydrate component that is separately dispersed within the polymeric matrix. The carbohydrate component modulates the release of the incorporated agent from the polymeric matrix. The compositions can be prepared by dissolving a biocompatible polymer in a solvent to form a polymer solution, and separately dispersing a carbohydrate and a prophylactic, therapeutic, and/or diagnostic agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein a significant amount of the carbohydrates is dispersed in the polymeric matrix separately from the incorporated agent.
    Type: Application
    Filed: April 25, 2006
    Publication date: April 24, 2008
    Inventors: Cindy W. Wu, Paul Burke, Merrill S. Goldenberg, Daxian Shan
  • Polyol/oil suspensions for the sustained release of proteins
    Patent number: 6979674
    Abstract: The present invention relates to the preparation of polyol/thickened oil suspensions containing a biologically active agent, for the sustained delivery of the biologically active agent. The described protein/glycerol/oil suspensions show sustained release of protein, e.g., G-CSF, of up to at least one week.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: December 27, 2005
    Assignee: Amgen Inc.
    Inventors: Merrill Goldenberg, Daxian Shan, Alice Beekman, Tiansheng Li
  • Polyol:oil suspensions for the sustained release of proteins
    Patent number: 6245740
    Abstract: The present invention relates to the preparation of polyol/thickened oil suspensions containing a biologically active agent, for the sustained delivery of the biologically active agent. The described protein/glycerol/oil suspensions show sustained release of protein, e.g., G-CSF, of up to at least one week.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: June 12, 2001
    Assignee: Amgen Inc.
    Inventors: Merrill Goldenberg, Daxian Shan, Alice Beekman