Patents by Inventor De Gao
De Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11904303Abstract: A method of forming an AFX zeolite in a hydrothermal synthesis that exhibits a silica to alumina (SiO2AI2O3) molar ratio (SAR) that is between 8:1 and 26:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (?m) to 10 ?m. This AFX zeolite also exhibits a Brönsted acidity that is in the range of 1.2 mmol/g to 3.6 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite exhibits about a 100% conversion of NO emissions over the temperature range of 300° C. to 650° C.Type: GrantFiled: November 8, 2019Date of Patent: February 20, 2024Assignee: Pacific Industrial Development CorporationInventors: De Gao, Yunkui Li, David Shepard, Jeffery Lachapelle, Wei Wu
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Publication number: 20240046097Abstract: A computer-implemented method for compressing a machine learning model includes converting an input machine learning model into a standard machine learning model. The method further includes converting the standard machine learning model into a plurality of pruned machine learning models, each of the pruned machine learning models converted using a corresponding pruning ratio from a pruning ratio candidate list. The method further includes determining, for each of the pruned machine learning models, a size-to-error ratio. The method further includes selecting, based on the size-to-error ratio of the pruned machine learning models, a first pruning ratio from the pruning ratio candidate list. The method further includes generating a compressed machine learning model by compressing the input machine learning model using the first pruning ratio that is selected. The method further includes deploying the compressed machine learning model for production.Type: ApplicationFiled: August 5, 2022Publication date: February 8, 2024Inventors: De Gao Chu, Lin Dong, Xiao Tian Xu, Xue Yin Zhuang
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Patent number: 11883804Abstract: A method of forming an SSZ-13 zeolite in a hydrothermal synthesis yields an SSZ-13 zeolite that exhibits a silica to alumina (SiO2:Al2O3) molar ratio (SAR) that is less than 16:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (?m) to 10 ?m. This SSZ-13 also exhibits a Brönsted acidity that is in the range of 2.0 mmol/g to 3.4 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite provides for low temperature light-off of the NOx conversion reactions, while maintaining substantial performance at higher temperatures demonstrating hydrothermal stability.Type: GrantFiled: October 24, 2019Date of Patent: January 30, 2024Assignee: Pacific Industrial Development CorporationInventors: De Gao, Yunkui Li, David Shepard, Jeffery Lachapelle, Wei Wu
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Patent number: 11771651Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.Type: GrantFiled: January 28, 2022Date of Patent: October 3, 2023Assignee: Academia SinicaInventors: Hsien-Ming Lee, Hua-De Gao, Jia-Lin Hong, Chih-Yu Kuo, Cheng-Bang Jian
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Publication number: 20220151926Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.Type: ApplicationFiled: January 28, 2022Publication date: May 19, 2022Applicant: Academia SinicaInventors: Hsien-Ming LEE, Hua-De GAO, Jia-Lin HONG, Chih-Yu KUO, Cheng-Bang JIAN
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Publication number: 20220153600Abstract: A method of continuously forming AEI-type zeolites in a tubular reactor via a hydrothermal synthesis. A gel composition formed upon using this method includes one or more sources of silica, alumina, organic structure directing agents (OSDA), alkali metal ions; water; and optionally zeolite seeds. This gel composition is defined by the molar ratios of SiO2/AI2O3 15:1 to 100:1; M2O/SiO2 0.15:1 to 0.30:1; ROH/SiO2 0.05:1 to 0.2:1; and H2O/SiO2 5:1 to 20:1; wherein M is the alkali metal ion and R is an organic moiety derived from the OSDA. This gel composition, after reacting at a temperature between 180° C. to about 220° C. for less than 2 hours forms the crystalline AEI-type zeolite having a silica to alumina ratio (SiO2/AI2O3) that is greater than 14:1.Type: ApplicationFiled: April 9, 2020Publication date: May 19, 2022Inventors: Yunkui Li, Wei Wu, De Gao, David Shepard, Jeffery Lachapelle, Geng Zhang
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Patent number: 11266603Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.Type: GrantFiled: June 28, 2019Date of Patent: March 8, 2022Inventors: Hsien-Ming Lee, Hua-De Gao, Jia-Lin Hong, Chih-Yu Kuo, Cheng-Bang Jian
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Publication number: 20210403334Abstract: A method of forming AEI-type zeolites in a hydrothermal synthesis without the use of hydrogen fluoride (HF) and in the presence of an FAU zeolite NaY with SAR ?5, a Y zeolite with a SAR ?5, or a combination thereof. A gel composition formed upon using this method includes one or more sources of silica, alumina, organic structure directing agents (OSDA), and alkali metal ions; zeolite seeds; and water. This gel composition is defined by the molar ratios of: SiO2/AI2O3 18:1 to 100:1; M2O/SiO2 0.15:1 to 0.30:1; ROH/SiO2 0.05:1 to 0.13:1; and H2O/SiO2 5:1 to 20:1; wherein M is the alkali metal ion and R is an organic moiety derived from the OSDA. This gel composition, after reacting at a temperature between 135° C. to about 200° C. for 10 hours to 168 hours forms the crystalline AEI-type zeolite having a silica to alumina ratio (SiO2:AI2O3) that is greater than 15:1.Type: ApplicationFiled: November 4, 2019Publication date: December 30, 2021Inventors: Yunkui Li, De Gao, David Shepard, Wei Wu, Jeffery Lachapelle, Geng Zhang
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Publication number: 20210394165Abstract: A method of forming an AFX zeolite in a hydrothermal synthesis that exhibits a silica to alumina (SiO2AI2O3) molar ratio (SAR) that is between 8:1 and 26:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (?m) to 10 ?m. This AFX zeolite also exhibits a Brönsted acidity that is in the range of 1.2 mmol/g to 3.6 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite exhibits about a 100% conversion of NO emissions over the temperature range of 300° C. to 650° C.Type: ApplicationFiled: November 8, 2019Publication date: December 23, 2021Inventors: De Gao, Yunkui Li, David Shepard, Jeffery Lachapelle, Wei Wu
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Publication number: 20210339233Abstract: A method of forming an SSZ-13 zeolite in a hydrothermal synthesis yields an SSZ-13 zeolite that exhibits a silica to alumina (SiO2:Al2O3) molar ratio (SAR) that is less than 16:1; has a morphology that includes one or more of cubic, spheroidal, or rhombic particles with a crystal size that is in the range of about 0.1 micrometer (?m) to 10 ?m. This SSZ-13 also exhibits a Brönsted acidity that is in the range of 2.0 mmol/g to 3.4 mmol/g as measured by ammonia temperature programmed desorption. A catalyst formed by substituting a metal into the framework of the zeolite provides for low temperature light-off of the NOx conversion reactions, while maintaining substantial performance at higher temperatures demonstrating hydrothermal stability.Type: ApplicationFiled: October 24, 2019Publication date: November 4, 2021Inventors: De Gao, Yunkui Li, David Shepard, Jeffery Lachapelle, Wei Wu
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Publication number: 20210323832Abstract: A method of forming an AEI-type zeolite in a hydrothermal synthesis without the use of hydrogen fluoride (HF) and in the absence of any FAU zeolite Y. A gel composition formed upon using this method includes one or more sources of silica; one or more sources of alumina, one or more organic structure directing agents (OSDA); a source of alkali metal ions; and water. This gel composition is defined by the molar ratios of: SiO2/AI2O3 16:1 to 100:1; M2O/SiO2 0.15:1 to 0.30:1; ROH/SiO2 0.05:1 to 0.20:1; and H2O/SiO2 5:1 to 20:1; wherein M is the alkali metal ion and R is an organic moiety derived from the OSDA. This gel composition, after reacting at a temperature between 135° C. to about 180° C. for 15 hours to 168 hours forms the crystalline AEI-type zeolite having a silica to alumina ratio (SiO2:AI2O3) that is greater than 8:1.Type: ApplicationFiled: August 23, 2019Publication date: October 21, 2021Inventors: Yunkui Li, David Shepard, De Gao, Wei Wu, Jeffery Lachapelle, Geng Zhang
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Publication number: 20200000722Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.Type: ApplicationFiled: June 28, 2019Publication date: January 2, 2020Applicant: Academia SinicaInventors: Hsien-Ming LEE, Hua-De GAO, Jia-Lin HONG, Chih-Yu KUO, Cheng-Bang JIAN
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Publication number: 20190336954Abstract: A crystalline, core-shell hybrid Chabazite (CHA) material for use as a catalyst has a core with a silicon to aluminum ratio (SAR) that is less than 25 and a shell that at least partially encapsulates the core, the shell having an SAR of about 25 or greater. The crystalline, core-shell hybrid Chabazite is prepared by forming a first chabazite (CHA) material having a silicon to aluminum ratio (SAR) that is less than 25, placing the first CHA material into an aqueous reaction mixture comprising one or more precursors capable of forming a second chabazite (CHA) material having an SAR that is 25 or greater, growing the second CHA material on the surface of the first CHA material, and collecting the core-shell hybrid CHA material.Type: ApplicationFiled: May 1, 2018Publication date: November 7, 2019Inventors: Wei Wu, Geng Zhang, De Gao, David Shepard, Yunkui Li, Jeffery Lachapelle
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Patent number: 5240481Abstract: A programmable control and operation system is applied in a swing pressure adsorption process. The system comprises a computer, a driving device, and a plurality of programmable control valve assemblies. The programmable control valve assembly comprises an operating valve with at least one cavity for sealing control, a valve core, a sealing ring, an operation device, a sealing control valve, and a valve position detector. The operation of the sealing control valve is dependent on the open or closed position of the valve and the process of opening and closing the valve. The sealing control valve feeds a sealing control medium at a pressure to the cavity for sealing the operating valve. The sealing control medium acts on the sealing ring to increase the pressure at the valve core to seal the operating valve. The control and operation system provide independent control of the sealing valve and operating valve to increase reliability and durability.Type: GrantFiled: August 3, 1992Date of Patent: August 31, 1993Assignee: Chengdu Huaxi Chemical Engineering Research InstituteInventors: Dong-Lin Li, Yi-Jiang Tang, Jiong-Liang Yang, Chong-Gang Zhang, De-Gao He