Abstract: The system provides information to facilitate efficient optimization of programmer settings for cardiac pacemakers. It simultaneously measures a patient's electrogram (EGM) and peripheral blood pressure (or volumetric displacement) waveform in order to calculate, in real-time and non-invasively, a value correlated to the pre-ejection time (PET) and, optionally, ejection duration (ED) for the patient's left ventricle. The peripheral pulse waveform can be monitored with a wrist mounted tonometer, or a suitable brachial cuff device. The time difference between the occurrence of the first detected positive or negative peak in a patient's LV electrogram trace (EGM) and the foot of the pulse on the peripheral pulse waveform is defined as a surrogate pre-ejection time interval (SPET).

Abstract: The system provides information to facilitate efficient optimization of programmer settings for cardiac pacemakers. It uses simultaneous measurement of a patient's electrocardiogram and peripheral blood pressure waveform in order to calculate, in real-time, a value correlated to the patient's pre-ejection time (PET) and, optionally, ejection duration (ED) for the patient's left ventricle. The peripheral blood pressure waveform is preferably monitored with a wrist mounted tonometer. Data including the electrocardiogram and peripheral blood pressure trace, as well as the surrogate pre-ejection time interval (SPET) for each heart beat and trending is displayed on a computer monitor, thereby allowing a physician or nurse to quickly optimize PET for the patient and adjusting programmer settings for an implanted pacemaker.

Abstract: The system provides information to facilitate efficient optimization of programmer settings for cardiac pacemakers. It uses simultaneous measurement of a patient's electrocardiogram and peripheral blood pressure waveform in order to calculate, in real-time, a value correlated to the patient's pre-ejection time (PET) and, optionally, ejection duration (ED) for the patient's left ventricle. The peripheral blood pressure waveform is preferably monitored with a wrist mounted tonometer. Data including the electrocardiogram and peripheral blood pressure trace, as well as the surrogate pre-ejection time interval (SPET) for each heart beat and trending is displayed on a computer monitor, thereby allowing a physician or nurse to quickly optimize PET for the patient and adjusting programmer settings for an implanted pacemaker.

Abstract: A method of monitoring cardiac output. The method uses a blood pressure waveform as input. The waveform is digitized and various blood pressure features are extracted. The features are used as inputs to a fuzzy logic model, where each input is fuzzified by determining its degree of confidence as a member of one or more fuzzy membership regions. A rule base is applied to the defuzzified inputs to obtain a fuzzy stroke volume index. This output is defuzzied and used to calculate cardiac output.