Abstract: An implantable device for delivering closed-loop neural stimulation therapy. The device comprises: a plurality of electrodes; a stimulus source to provide neural stimuli via the electrodes to a neural pathway; measurement circuitry to process signals sensed at the electrodes; and a control unit. The control unit is configured to: control the stimulus source to provide a first neural stimulus according to a first stimulus parameter; measure an intensity of a neural response evoked by the first stimulus; compute a feedback variable from the neural response; adjust the first stimulus parameter; repeat the control, measure, compute and adjust to maintain the feedback variable at a target response intensity; control the stimulus source to provide, interleaved with the first neural stimuli, a plurality of second neural stimuli according to respective second stimulus parameters; and monitor the therapy by analysing the sensed signals subsequent to each second neural stimulus.

Abstract: Disclosed is a method of computing a probability distribution of the suitability of measurement electrode configurations for a neuromodulation device. The method comprises: computing the probability distribution of suitability of measurement electrode configurations from: a predetermined stimulus program vector of the neuromodulation device; and prior patient data. Also disclosed is an automated method of setting a measurement electrode configuration for a neuromodulation device configured to deliver a neural stimulus to a neural pathway of a patient.

Abstract: An implantable pulse generator device (110) comprising a processor (117) configured to: receive, in a charging mode, electromagnetic radiation (106) from a charging device (102) wherein the electromagnetic radiation (106) transfers energy to the implantable device (110) to charge an energy storage device (104); measure, in a measurement mode, an electrical field parameter signal representing a neural response; and selectively transition between the charging mode and the measurement mode, such that the implantable device (110) does not receive electromagnetic radiation (106) from the charging device (102) during the measurement of the electrical field parameter signal.

Abstract: Disclosed is an implantable device for controllably delivering a neural stimulus. The device comprises: a plurality of electrodes including one or more stimulus electrodes and one or more sense electrodes; a stimulus source configured to provide a neural stimulus to be delivered via the one or more stimulus electrodes to a neural pathway of a patient in order to evoke a neural response on the neural pathway; measurement circuitry configured to process a signal window sensed at the one or more sense electrodes subsequent to the delivered neural stimulus, the sensed signal window including an evoked neural response; and a control unit.

Abstract: Disclosed is a neuromodulation system comprising a neuromodulation device for controllably delivering a neural stimulus, and a processor.

Abstract: Embodiments of the disclosure relate to an antenna device. The antenna device includes a glass sheet having a first major surface and a second major surface opposite to the first major surface. The first major surface and the second major surface define a thickness of the glass sheet. The antenna device also includes at least one patch antenna. Each of the at least one patch antenna includes a first metallic layer that is located within the thickness of the glass sheet at or below the first major surface. Additionally, the antenna device includes a ground plane comprising a second metallic layer that is located within the thickness of the glass sheet at or below the second major surface.

Abstract: Embodiments of the present disclosure are directed towards a system and method using a subterranean biological reactor. Embodiments may include a pre-reactor storage unit configured to receive a feedstock including a slurry of biologically derived material and at least one pump configured to pump the effluent from the pre-reactor storage unit. The system may include at least one wellbore containing a subterranean biological reactor configured to receive the effluent from the pre-reactor storage unit. At least a portion of the subterranean biological reactor may be configured to perform anaerobic digestion upon the effluent to generate a biogas.

Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.

Abstract: A storage system comprises a rack defining a plurality of storage locations arranged one above the other, trays removably stored at the storage locations, and an elevator configured for moving a selected tray between its assigned storage location and a retrieval space below the storage locations. The storage locations are formed by pairs of horizontally opposite spaced apart rails with inwardly projecting sidewalls on which a tray can be rested. The elevator comprises a platform configured to carry and transfer the trays to and from the rack, and a drive system configured to move the platform that includes a servomotor. The platform carries optical sensors used cooperatively with the servomotor to detect a selected storage location of a tray to be stored or retrieved.

Abstract: A method for in-situ measurement of a thickness of a coating deposited by a deposition process, includes the steps of initiating deposition within a deposition chamber such that a first coating forms on an outer surface of a probe disposed in the deposition chamber, wherein the probe comprises a coil assembly including at least one coil, wherein the probe is separated by a distance from a substrate disposed within the deposition chamber; exciting the coil assembly with a first alternating current to produce a first time-varying magnetic field, the first time-varying magnetic field generating an eddy current in the first coating; determining a metric related to an inductance or resistance of the coil assembly, wherein a value of the metric is related to a first thickness of the first coating and results at least partially from an eddy current magnetic field produced by an eddy current in the coating; and correlating the first thickness of the first coating to a second thickness of a second coating deposited on

Abstract: A system and method using a subterranean biological reactor can include a pre-reactor storage unit configured to receive a feedstock including a slurry of biologically derived material and at least one pump configured to pump the effluent from the pre-reactor storage unit. The system may include at least one wellbore containing a subterranean biological reactor configured to receive the effluent from the pre-reactor storage unit. At least a portion of the subterranean biological reactor may be configured to perform anaerobic digestion upon the effluent to generate a biogas.

Abstract: Disclosed is an implantable device for lead offset determination, comprising first and second electrode leads. A stimulus is delivered from one lead to tissue, and a signal is sensed from the tissue by the other lead. The sensed signal is processed to produce a measure of a stimulus artefact present in the signal. The stimulus artefact measure is used to produce a measure of an offset between the first electrode lead and the second electrode lead, such as by applying a distance-squared. analytical model to measures of stimulus artefact obtained from at least two sense electrodes. And/or, a compound action potential evoked by the stimulus is sensed from neural tissue, a latency of the evoked compound action potential is measured, and a measure of an offset between the first electrode lead and the second electrode lead is produced from the latency.

Abstract: An electronic apparatus includes a substrate including a first major surface, a second major surface, and an edge surface. The edge surface includes a radius of curvature extending between the first major surface and the second major surface. The electronic apparatus includes an opto-electronic device positioned on the first major surface. The electronic apparatus includes an electrical component positioned on the second major surface. The electronic apparatus includes a first electrically-conductive trace attached to the edge surface. The first electrically-conductive trace electrically connects a first portion of the opto-electronic device to the electrical component and defines a first current path. The electronic apparatus includes a second electrically-conductive trace extending through an opening in the substrate.

Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.

Abstract: An encrypted payment message is received from a buyer relating to a transaction with a merchant. The payment message is parsed using a first parsing algorithm to obtain merchant identifying information. The merchant identifying information is associated with at least a second parsing algorithm or at least one settlement algorithm. The payment message is parsed using the second parsing algorithm to obtain payment information for the transaction. A first settlement algorithm is applied to the payment information to determine an adjusted interchange rate. The payment information including the adjusted interchange rate is submitted to a third party settlement processor on behalf of the merchant, using a payment algorithm. A second settlement algorithm applied to the payment information determines a buyer rebate which can be submitted to the settlement processor. A transaction result is reported to at least one of the merchant or the buyer.

Abstract: Embodiments of the disclosure relate to an antenna device. The antenna device includes a glass sheet having a first major surface and a second major surface opposite to the first major surface. The first major surface and the second major surface define a thickness of the glass sheet. The antenna device also includes at least one patch antenna. Each of the at least one patch antenna includes a first metallic layer that is located within the thickness of the glass sheet at or below the first major surface. Additionally, the antenna device includes a ground plane comprising a second metallic layer that is located within the thickness of the glass sheet at or below the second major surface.

Abstract: Disclosed is a method of adapting the operation of an implantable device for delivering neurostimulation therapy to a patient. The method comprises: delivering the neurostimulation therapy to electrically excitable tissue of the patient according to at least one therapy parameter; measuring a physiological characteristic of the patient; adjusting the at least one therapy parameter according to a schedule of adjustment and the measured physiological characteristic; and repeating the delivering, measuring, and adjusting.

Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.

Abstract: Embodiments of the disclosure relate to an antenna device. The antenna device includes a glass sheet having a first major surface and a second major surface opposite to the first major surface. The first major surface and the second major surface define a thickness of the glass sheet. The antenna device also includes at least one patch antenna. Each of the at least one patch antenna includes a first metallic layer that is located within the thickness of the glass sheet at or below the first major surface. Additionally, the antenna device includes a ground plane comprising a second metallic layer that is located within the thickness of the glass sheet at or below the second major surface.

Abstract: An encrypted payment message is received from a buyer relating to a transaction with a merchant. The payment message is parsed using a first parsing algorithm to obtain merchant identifying information. The merchant identifying information is associated with at least a second parsing algorithm or at least one settlement algorithm. The payment message is parsed using the second parsing algorithm to obtain payment information for the transaction. A first settlement algorithm is applied to the payment information to determine an adjusted interchange rate. The payment information including the adjusted interchange rate is submitted to a third party settlement processor on behalf of the merchant, using a payment algorithm. A second settlement algorithm applied to the payment information determines a buyer rebate which can be submitted to the settlement processor. A transaction result is reported to at least one of the merchant or the buyer.