Patents by Inventor Debabrata RayChaudhuri

Debabrata RayChaudhuri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of Inhibitors of FtsZ
    Publication number: 20090221568
    Abstract: FtsZ, the bacterial analog of tubulin, is a promising new target for developing new antibiotics. It has been shown that polyphenols inhibit the GTPase activity of FtsZ, thereby inhibiting Z-ring formation during mitosis. The present invention provides novel polyphenols compounds, which can be accessed by the synthesis of dichamametin and 2??-hydroxy-5?-benzylisouvarinol-B as described herein. These novel compounds are useful in treating infections, particularly infections caused by gram-positive organisms. Methods of preparing the inventive compounds are also provided. The compounds are prepared by the benzylation of pinocembrin or chrysin core structure. Pharmaceutical compositions and method of using the compounds to treat disease are also provided. These compounds may be screened for antimicrobial activity as well as other biological activities such as anti-neoplastic, anti-inflammatory, immunosuppressive, and cytotoxic activity.
    Type: Application
    Filed: November 3, 2006
    Publication date: September 3, 2009
    Inventors: Jared Shaw, Sameer Urgaonkar, Debabrata RayChaudhuri, Henry La Pierre
  • In vivo assay for identification of antimicrobial agents
    Patent number: 7011946
    Abstract: The present invention provides novel in vivo assay systems and methods of using these assays systems to identify compounds that affect microbial cell division. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: March 14, 2006
    Assignees: Trustees of Tufts College, President and Fellows of Harvard College
    Inventors: Debabrata RayChaudhuri, Marc Kirschner
  • In vivo assay for identification of antimicrobial agents
    Publication number: 20030138869
    Abstract: The present invention provides novel in vivo assay systems and methods of using these assays systems to identify compounds that affect microbial cell division. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.
    Type: Application
    Filed: June 26, 2002
    Publication date: July 24, 2003
    Applicant: President and Fellows of Harvard College
    Inventors: Debabrata RayChaudhuri, Marc Kirschner
  • Identification of antimicrobial agents
    Publication number: 20030017521
    Abstract: The present invention provides novel assay systems and methods of using these assays systems for identifying compounds that affect microbial cell division. The present invention further provides pharmaceutical compositions that have anti-microbial activity and methods of treating microbial infections.
    Type: Application
    Filed: May 22, 2002
    Publication date: January 23, 2003
    Applicant: President and Fellows of Harvard College
    Inventors: Debabrata RayChaudhuri, Danielle Margalit, Marc Kirschner