Patents by Inventor Debendranath Dey
Debendranath Dey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230226082Abstract: Methods and formulations for treating and preventing LONG COVID sequelae are provided. An example method treats loss of smell and taste from SARS-CoV-2 infection, including assessing the patient, administering a composition with dosage between 1750-3600 mg per day, wherein the composition comprises a mixture of at least a withanolide-A, a boswellic acid, a [6]-gingerol, and a curcuminoid. Another example method treats memory loss or brain fog from SARS-CoV-2 infection, including assessing the patient, and administering a regenerative and neuroprotective composition comprising a mixture of withanoside VI, withanolide A, a Boswellia serrata plant, a Zingiber officinale rhizome, and a Curcuma longa rhizome. The compositions were found effective, achieving statistical significance in a multi-center, randomized, double-blind, placebo-controlled phase III clinical trial.Type: ApplicationFiled: November 10, 2022Publication date: July 20, 2023Applicant: Bioved Pharmaceuticals, Inc.Inventors: Deepa Chitre, Debendranath Dey, Satej R Nadkarni
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Patent number: 11628197Abstract: Methods and compounds for preventing and arresting COVID-19 morbidity and mortality, via inhibition of Interleukin-6, TNF-alpha, and other cytokines, and via reduction of C-reactive proteins are provided. Analyses of patients with COVID-19 complicated by ARDS, for example, show highly activated cytotoxic T-cells, resulting from hyperactivation of the immune system. A significant surge of Interleukin-6 (IL-6), TNF-?, and other cytokines are thought to be mediators of this enhanced T-cell activity, and runaway inflammation that are dangerous or fatal to the patient. Example oral formulations dubbed BV-4051 and Artovid-20 provide prophylaxis and treatment of these conditions caused by COVID-19 disease. The example formulations contain plant extracts boosting the human immune system and targeting the detrimental effects of the SARS-CoV-2 virus in its various strains.Type: GrantFiled: May 3, 2021Date of Patent: April 18, 2023Assignee: Bioved Pharmaceuticals, IncInventors: Deepa Chitre, Debendranath Dey, Satej R Nadkarni
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Publication number: 20210338765Abstract: Methods and compounds for preventing and arresting COVID-19 morbidity and mortality, via inhibition of Interleukin-6, TNF-alpha, and other cytokines, and via reduction of C-reactive proteins are provided. Analyses of patients with COVID-19 complicated by ARDS, for example, show highly activated cytotoxic T-cells, resulting from hyperactivation of the immune system. A significant surge of Interleukin-6 (IL-6), TNF-?, and other cytokines are thought to be mediators of this enhanced T-cell activity, and runaway inflammation that are dangerous or fatal to the patient. Example oral formulations dubbed BV-4051 and Artovid-20 provide prophylaxis and treatment of these conditions caused by COVID-19 disease. The example formulations contain plant extracts boosting the human immune system and targeting the detrimental effects of the SARS-CoV-2 virus in its various strains.Type: ApplicationFiled: May 3, 2021Publication date: November 4, 2021Applicant: Bioved Pharmaceuticals, Inc.Inventors: DEEPA CHITRE, DEBENDRANATH DEY, SATEJ R. NADKARNI
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Patent number: 10036755Abstract: The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: GrantFiled: April 2, 2015Date of Patent: July 31, 2018Assignee: Prosetta Antiviral, Inc.Inventors: Vishwanath R. Lingappa, Debendranath Dey
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Publication number: 20170242027Abstract: The present invention provides compositions and methods of use in investigations of the formation of multiprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: February 9, 2017Publication date: August 24, 2017Inventors: Vishwanath R. Lingappa, Debendranath Dey
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Publication number: 20170119835Abstract: A method of obtaining one or more fractions from a plant material of Withania somnifera (WS) is disclosed. The method includes subjecting the plant material to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain at least one extract. The method further includes subjecting the at least one extract obtained from the hydro-alcoholic extraction to at least one of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain Withaferin A in a concentration greater than concentrations of other pharmacologically active ingredients present in the one or more fractions. The one or more fraction thus obtained and one or more compositions containing the one or more fractions are effective in inhibiting proliferation of mammalian cancerous cells.Type: ApplicationFiled: September 7, 2016Publication date: May 4, 2017Inventors: Deepa Chitre, Debendranath Dey, Sunetra Chaskar
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Publication number: 20170007625Abstract: The invention provides method and composition for alleviating one or more symptoms associated with a medical condition mediated by one or more of a cyclooxygenase, a pro-inflammatory cytokine, and a pro-inflammatory enzyme. The method includes administering an effective amount of a composition to a person suffering from the medical condition. The composition essentially includes a set of plant extracts. The set of plant extracts include an extract of Withania somnifera, an extract of Boswellia serrata, an extract of Curcuma longa, and an extract of Zingiber officinale. Wherein, one or more extracts of the set of plant extracts includes one or more desired active ingredient in an amount greater than an amount of other active ingredients present in the one or more extracts. The composition can also be used as combination therapy with any other known anti-inflammatory agents.Type: ApplicationFiled: February 20, 2015Publication date: January 12, 2017Applicant: BIOVED PHARMACEUTICALS, INC.Inventors: DEEPA CHITRE, DEBENDRANATH DEY
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Publication number: 20150226748Abstract: The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: April 2, 2015Publication date: August 13, 2015Inventors: Vishwanath R. Lingappa, Debendranath Dey
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Publication number: 20150164972Abstract: A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extracts to one or more of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain a desired pharmacologically active ingredient in concentration greater than concentrations of other pharmacologically active ingredients present in the at least one fraction. Further, the one or more fractions are less toxic as compared with corresponding one or more fractions obtained by conventional methods. In addition, the one or more fractions are therapeutically more effective in various diseases as compared to one or more fractions obtained by conventional methods.Type: ApplicationFiled: August 18, 2014Publication date: June 18, 2015Applicant: BIOVED PHARMACEUTICALS, INC.Inventors: DEEPA CHITRE, DEBENDRANATH DEY
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Publication number: 20140363526Abstract: A composition of matter comprising a synergistic formulation of plant extracts for hepatic and adrenal disorders is provided. In an implementation, an example extraction method for concentrating pharmacologically active fractions of plants provides a synergistically active compound containing approximately 5%-25% extract of Andrographis paniculata, approximately 10%-30% extract of Boerhavia diffusa, approximately 25%-50% extract of Phyllanthus niruri, and approximately 15%-40% extract of Tephrosia purpurea. The synergistically active compound provides greater therapeutic benefit than the individual ingredients alone, or the combined ingredients in different concentration ranges. The synergistic formulation may also be used for treatment of other medical conditions.Type: ApplicationFiled: June 6, 2014Publication date: December 11, 2014Applicant: BIOVED PHARMACEUTICALS, INC.Inventors: DEEPA CHITRE, NARENDRA BHATT, DEBENDRANATH DEY, SUNETRA CHASKAR
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Patent number: 8808769Abstract: A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extracts to one or more of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain a desired pharmacologically active ingredient in concentration greater than concentrations of other pharmacologically active ingredients present in the at least one fraction. Further, the one or more fractions are less toxic as compared with corresponding one or more fractions obtained by conventional methods. In addition, the one or more fractions are therapeutically more effective in various diseases as compared to one or more fractions obtained by conventional methods.Type: GrantFiled: May 21, 2010Date of Patent: August 19, 2014Assignee: Bioved Pharmaceuticals, Inc.Inventors: Deepa Chitre, Debendranath Dey
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Publication number: 20140106365Abstract: The present invention provides compositions and methods of use in investigations of the formation of multiprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: July 24, 2013Publication date: April 17, 2014Applicant: Prosetta Antiviral, Inc.Inventors: Vishwanath R. LINGAPPA, Debendranath Dey
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Publication number: 20120301904Abstract: The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: April 26, 2012Publication date: November 29, 2012Applicant: Prosetta Antiviral, IncInventors: Vishwanath R. Lingappa, Clarence R. Hurt, Debendranath Dey
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Publication number: 20120070521Abstract: A method of obtaining one or more fractions from a plant material of Withania somnifera (WS) is disclosed. The method includes subjecting the plant material to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain at least one extract. The method further includes subjecting the at least one extract obtained from the hydro-alcoholic extraction to at least one of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain Withaferin A in a concentration greater than concentrations of other pharmacologically active ingredients present in the one or more fractions. The one or more fraction thus obtained and one or more compositions containing the one or more fractions are effective in inhibiting proliferation of mammalian cancerous cells.Type: ApplicationFiled: May 21, 2010Publication date: March 22, 2012Applicant: Bio-Ved Pharmaceuticals, PVT., Ltd.Inventors: Deepa Chitre, Debendranath Dey, Sunetra Chaskar, Sachin Chaturvedi
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Publication number: 20120070519Abstract: A method of obtaining one or more fractions from one or more plants is disclosed. The method includes subjecting one or more parts of the one or more plants to hydro-alcoholic extraction in presence of a water-insoluble solvent to obtain one or more extracts. The method further includes subjecting the one or more extracts to one or more of de-pigmentation, de-fatting and detoxification process to obtain the one or more fractions. The one or more fractions thus obtained contain a desired pharmacologically active ingredient in concentration greater than concentrations of other pharmacologically active ingredients present in the at least one fraction. Further, the one or more fractions are less toxic as compared with corresponding one or more fractions obtained by conventional methods. In addition, the one or more fractions are therapeutically more effective in various diseases as compared to one or more fractions obtained by conventional methods.Type: ApplicationFiled: May 21, 2010Publication date: March 22, 2012Applicant: BIO-VED Pharmaceuticals, Pvt. Ltd.Inventors: Deepa Chitre, Debendranath Dey
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Publication number: 20100305174Abstract: The present invention relates to novel heterocyclic derivatives of formula (I) and their pharmaceutically acceptable salts, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts, their pharmaceutical compositions, and their prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (1).Type: ApplicationFiled: April 12, 2006Publication date: December 2, 2010Applicant: ORCHID RESEARCH LABORATORIES LIMITEDInventors: Surendrakumar Satyanarayan Pandey, Gadam Om Reddy, Shiv Kumar Agarwal, Gajendra Singh, Santhanagopalan Chithra, Debendranath Dey, Abhijeet Nag, Kadnur Venkatachalapathi Sanjay
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Patent number: 7781464Abstract: The present invention relates to novel heterocyclic diphenyl ether and diphenyl amine compounds, derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof and pharmaceutically acceptable compositions containing these singly or in combination. The compounds of the present invention are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels and are useful in the treatment and/or prophylaxis of diabetes. The compounds of the present invention are effective in treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and immunological diseases, including the treatment of cancer. Furthermore, the compounds are useful for the treatment of disorders associated with insulin resistance.Type: GrantFiled: February 21, 2006Date of Patent: August 24, 2010Assignee: Bexel Pharmaceuticals, Inc.Inventors: Partha Neogi, Bishwajit Nag, Debendranath Dey, Abhijeet Nag, Birendra Kumar Bhattacharya, Vinod Kumar Singh, Surendradoss Jayakumar
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Publication number: 20100150865Abstract: The invention provides method and composition for alleviating one or more symptoms associated with a medical condition mediated by one or more of a cyclooxygenase, a pro-inflammatory cytokine, and a pro-inflammatory enzyme. The method includes administering an effective amount of a composition to a person suffering from the medical condition. The composition essentially includes a set of plant extracts. The set of plant extracts include an extract of Withania somnifera, an extract of Boswellia serrata, an extract of Curcuma longa, and an extract of Zingiber officinale. Wherein, one or more extracts of the set of plant extracts includes one or more desired active ingredient in an amount greater than an amount of other active ingredients present in the one or more extracts. The composition can also be used as combination therapy with any other known anti-inflammatory agents.Type: ApplicationFiled: December 8, 2009Publication date: June 17, 2010Inventors: Deepa Chitre, Debendranath Dey
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Patent number: 7718682Abstract: Novel diphenylethylene compounds and derivatives thereof containing thiazolidinedione or oxazolidinedione moieties are provided which are effective in lowering blood glucose level, serum insulin, triglyceride and free fatty acid levels in animal models of Type II diabetes. The compounds are disclosed as useful for a variety of treatments including the treatment of inflammation, inflammatory and immunological diseases, insulin resistance, hyperlipidemia, coronary artery disease, cancer and multiple sclerosis.Type: GrantFiled: April 2, 2008Date of Patent: May 18, 2010Assignee: Theracos, Inc.Inventors: Partha Neogi, Debendranath Dey, Satyanarayana Medicherla, Bishwagit Nag, Arthur Lee
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Publication number: 20090203744Abstract: The present invention relates to novel pyridine derivatives of the formula (I), their stereoisomers, and their pharmaceutically acceptable salts, and compositions. The present invention more particularly provides novel pyridine derivatives of the general formula (I).Type: ApplicationFiled: July 28, 2006Publication date: August 13, 2009Inventors: Surendrakumar Satyanarayan Pande y, Gaddam Om Reddy, Gajendra Singh, Santhanagopalan Chithra, Jeganath Sivakumar, Venkatachalapathi Sanjay Kadnur, Debendranath Dey