Patents by Inventor Debra Ainge

Debra Ainge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
    Patent number: 8466284
    Abstract: The invention provides certain novel compounds as listed in the specification and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: June 18, 2013
    Assignee: Astra Zeneca AB
    Inventors: David Chapman, Martin Lindsjö, Hans Lönn, Michael Lundkvist, Magnus Munck AF Rosenschöld, Antonios Nikitidis, Debra Ainge, John Pavey
  • Pharmaceutical process and intermediates 714
    Patent number: 8227622
    Abstract: The invention relates to compounds of formula (X), and salts thereof, and their use as intermediates in improved manufacturing processes for the synthesis of pharmaceutical compound (I): X is ?O, ?N—OH or ?N—OC(O)Me; Y is hydrogen, PhS- or p-chlorophenylsulfanyl; Z is hydrogen or —CH2COOR1 wherein R1 is selected from hydrogen, optionally substituted hydrocarbyl and optionally substituted heterocyclyl.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: July 24, 2012
    Assignee: AstraZeneca AB
    Inventors: Debra Ainge, Eric Merifield, Colin Thomson, Michael Butters, Ravi Ramakrishnan, Ravi Naidu Rayapati, Parhalad Ray Sharma
  • Pharmaceutical Process and Intermediates 714
    Publication number: 20110046394
    Abstract: The invention relates to compounds of formula (X), and salts thereof, and their use as intermediates in improved manufacturing processes for the synthesis of pharmaceutical compound (I): X is ?O, ?N—OH or ?N—OC(O)Me; Y is hydrogen, PhS- or p-chlorophenylsulfanyl; Z is hydrogen or —CH2COOR1 wherein R1 is selected from hydrogen, optionally substituted hydrocarbyl and optionally substituted heterocyclyl.
    Type: Application
    Filed: July 6, 2010
    Publication date: February 24, 2011
    Inventors: Debra Ainge, Eric Merifield, Colin Thomson, Michael Butters, Ravi Ramakrishnan, Ravi Naidu Rayapati, Parhalad Ray Sharma
  • Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
    Publication number: 20100280048
    Abstract: The invention provides certain novel 6-heteroaryl-5-methyl-3-oxo-4-[3(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide derivatives and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
    Type: Application
    Filed: November 5, 2008
    Publication date: November 4, 2010
    Applicant: ASTRAZENECA R&D
    Inventors: Debra Ainge, David Chapman, Martin Lindsjo, Hans Lonn, Michael Lundkvist, Magnus Munck AF Rosen-Schold, Antonios Nikitidis, John Pavey
  • Process for preparing dibenzothiazepine compounds
    Patent number: 7671195
    Abstract: A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2?-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2?-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2?-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2?-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: March 2, 2010
    Assignees: AstraZeneca UK Limited, UBE Industries, Ltd.
    Inventors: Paul Michael Murray, Luis-Manuel Vaz, Debra Ainge, Katsumasa Harada, Shigeyoshi Nishino, Kiyotaka Yoshii
  • Process for the Preparation of Substituted 2-Acetylamino-Alkoxyphenyl
    Publication number: 20100041905
    Abstract: The present invention relates to a novel process for the preparation of compounds of formula (V) wherein X, Q, R1, R1a and R2 are as defined in the specification, the compounds being useful in the preparation of therapeutic agents.
    Type: Application
    Filed: July 17, 2007
    Publication date: February 18, 2010
    Applicant: ASTRAZENECA AB
    Inventors: Debra Ainge, Philip Cornwall, Duncan Michael Gill, Luis Manuel Vaz
  • Novel Process 1
    Publication number: 20080064884
    Abstract: The present invention relates to a novel process for the preparation of compounds of formula (I) wherein X, Q, R1 and R2 are as defined in the specification, the compounds being useful in the preparation of therapeutic agents. The invention further relates to novel intermediates useful in the preparation of the therapeutic agents.
    Type: Application
    Filed: May 3, 2007
    Publication date: March 13, 2008
    Applicant: AstraZeneca AB
    Inventors: Debra Ainge, Philip Cornwall, Duncan Michael Gill, Vinod Kumar, Luis Manuel Vaz, Philip O'Keefe, Rhona Sinclair, Edward Laurence Way
  • Process for preparing dibenzothiazepine compounds
    Publication number: 20070203336
    Abstract: A dibenzothiazepine compound is suitably prepared by subjecting a 2-amino-2?-carboxy-diphenylsulfide compound to dehydration-condensation reaction in the presence of an acidic catalyst; the 2-amino-2?-carboxy-diphenylsulfide compound is suitably prepared by reducing a 2-nitro-2?-carboxy-diphenylsulfide compound in a lower aliphatic ester solvent; and the 2-nitro-2?-carboxy-diphenylsulfide compound is suitably prepared by reacting a nitrobenzene compound with a thiosalicylic acid compound in a mixture of a lower aliphatic alcohol and water.
    Type: Application
    Filed: February 21, 2007
    Publication date: August 30, 2007
    Inventors: Paul Murray, Luis-Manuel Vaz, Debra Ainge, Katsumasa Harada, Shigeyoshi Nishino, Kiyotaka Yoshii