Patents by Inventor Debra L. Laskin

Debra L. Laskin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PULMONARY FUNCTION TREATMENT
    Publication number: 20230302018
    Abstract: A method of treating reduced pulmonary function by administering an effective dose of a Farnesoid X Receptor (FXR) agonist, particularly obeticholic acid, is disclosed. Also disclosed is an in vivo animal model of lung injury and altered functioning, useful for identifying compounds active in restoring pulmonary function.
    Type: Application
    Filed: March 27, 2023
    Publication date: September 28, 2023
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Debra L. Laskin, Jaclynn A. Meshanni, Grace L. Guo, Andrew J. Gow, Jeffrey D. Laskin
  • Suppression of nitric oxide production by osteopontin
    Patent number: 5695761
    Abstract: The present invention relates to compositions and methods for inhibition of the vasoactive and signal transduction agent nitric oxide (NO), and to therapeutic treatment of diseases or disorders that involve inappropriate or detrimental NO activity. The invention particularly relates to modulation of kidney function. In specific embodiments, osteopontin and a 20-amino acid fragment of osteopontin that contains an Arg-Gly-Asp sequence suppress expression of inducible NO synthase mRNA, and osteopontin suppresses the activity of constitutive NO synthase.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: December 9, 1997
    Assignees: Rutgers University, University of Medicine & Dentistry of NJ
    Inventors: David T. Denhardt, Shiaw-Min Hwang, Diane Elaine Heck, Cecilia Ang Lopez, Debra L. Laskin, Jeffrey D. Laskin