Abstract: The present invention relates to mRNA medicines for use in the therapy and prevention of liver diseases like liver fibrosis, liver cirrhosis, hepatocellular carcinoma (HCC), non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) or liver cancer, and more particularly to mRNA medicines of this kind which can exhibit excellent therapeutic and preventive effects with respect to liver diseases individually developed or to complications resulting from diseases of these organs. In detail, the present invention relates to an mRNA suitable for treatment or prophylaxis of liver diseases. In particular, the present invention provides mRNAs encoding hepatocyte nuclear factor 4 alpha (HNF4A), human wild type and engineered variants thereof), or a fragment or a variant of any of these peptides or proteins. The present invention concerns said mRNA as well as compositions and kits comprising the mRNA.

Abstract: The invention provides a system and methods for retrieving selected supply chain data from various supply chain information databases and presenting the selected data to a user for viewing. The invention allows sharing of supply chain information by receiving a data request from a user, filtering the data request, issuing a data request to an application that retrieves the data from at least one associated database, organizing the data retrieved by the application, and sending the organized data for display to the user that originated the request. The invention also provides a two-tier security system whereby the user's data access is restricted to the type of data that it is authorized to view as well as confining the user's access to predetermined fields within that data type. Finally, the invention provides a system and methods for organizing the data presented to the user in a logical and efficient manner that is responsive to the user's preferences.