Patents by Inventor Dena Lyras

Dena Lyras has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES FOR BINDING PLASMINOGEN
    Publication number: 20220380484
    Abstract: The present invention relates to antigen binding proteins comprising an antigen binding domain that binds to plasminogen, wherein the antigen binding protein reduces the activation of plasminogen to plasmin, pharmaceutical compositions comprising the same, and methods and uses thereof.
    Type: Application
    Filed: October 28, 2020
    Publication date: December 1, 2022
    Inventors: James Whisstock, Ruby Law, Adam Quek, Paul Conroy, Dena Lyras, Guojie Wu
  • Methods and compositions for the treatment and/or prophylaxis of associated disease
    Patent number: 10144775
    Abstract: The present invention relates to methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease (CD AD). In particular, the invention relates to antibodies that bind to C. difficile antigens and are capable of inhibiting C. difficile infection, at least one symptom of C. difficile associated disease, shedding of C. difficile, and C. difficile associated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to a C. difficile Toxin B; and mammalian or avian antibodies that bind to a C. difficile vegetative cell antigen and/or a C. difficile endospore antigen.
    Type: Grant
    Filed: April 17, 2014
    Date of Patent: December 4, 2018
    Assignee: IMMURON LIMITED
    Inventors: Dena Lyras, Melanie Hutton, Bliss Cunningham, Lucy Li, Glen Carter, Julian Rood
  • METHODS AND COMPOSITIONS FOR THE TREATMENT AND/OR PROPHYLAXIS OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE
    Publication number: 20160083457
    Abstract: The present invention relates to methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease (CD AD). In particular, the invention relates to antibodies that bind to C. difficile antigens and are capable of inhibiting C. difficile infection, at least one symptom of C. difficile associated disease, shedding of C. difficile, and C. difficile associated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to a C. difficile Toxin B; and mammalian or avian antibodies that bind to a C. difficile vegetative cell antigen and/or a C. difficile endospore antigen.
    Type: Application
    Filed: April 17, 2014
    Publication date: March 24, 2016
    Applicant: IMMURON LIMITED
    Inventors: Dena LYRAS, Melanie HUTTON, Bliss CUNNINGHAM, Lucy LI, Glen CARTER, Julian ROOD
  • Expression system for clostridium species
    Patent number: 5955368
    Abstract: A system is used to express clostridial gene constructions in a clostridial host. A mobilizable transfer plasmid is described which permits the direct transfer of the plasmid, and genes carried on it, from E. coli into Clostridium species. A promoter is described for use in clostridial species. Also, a useful host strain is used which is nontoxigenic and which permits high levels of expression of clostridial genes using the clostridial promoter.
    Type: Grant
    Filed: April 6, 1998
    Date of Patent: September 21, 1999
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric A. Johnson, Marite Bradshaw, Julian I. Rood, Dena Lyras