Abstract: Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the MT1-MMP cytoplasmic domain is capable of inhibiting MT1-MMP in a dominant negative manner, the present invention provides compositions including MT1-MMP inhibitors such as peptide inhibitors, and methods for treating diseases associated with MT1-MMP activity. Such diseases include cancer, arthritis, and heart disease, and vascular disease.

Abstract: Based on the discovery that a soluble polypeptide including a nonphosphorylatable form of the cytoplasmic domain is capable of inhibiting in a dominant negative manner, the present invention provides compositions including MT1-MMP inhibitors such as peptide inhibitors, and methods for treating diseases associated with MT1-MMP activity. Such diseases include cancer, arthritis, and heart disease, and vascular disease.

Abstract: A sport shoe comprises a sole and an upper portion attached to the sole and defining an inner space with the sole, and having an entrance opening for receiving a user's foot therethrough, into the inner space, and an attachment system to secure the user's foot therein, the sport shoe having, in longitudinal succession, a heel cage, a middle section, and a toe box, the middle section having at least four generally transversally-oriented strips in the upper portion, including tightening strips receiving the attachment system externally and having a heat-moldable layer internally, and flexibility strips, the tightening strips and flexibility strips being in longitudinally alternating succession, at least a section of the flexibility strips being heat moldable layer free.

Abstract: The present invention generally relates to stabilization straps, and is more specifically concerned with a helmet stabilization strap apparatus. The stabilization strap apparatus provides connectors so configured and sized as to be mountable on the helmet, and each include a first pivotal interconnecting element and a first interlocking element. The stabilization strap apparatus further includes a strap member having ends connectable to a respective connector. Each of the ends includes a second pivotal interconnecting element and a second interlocking element, such that the second pivotal interconnecting element is mountable in a pivotal connection to the first pivotal interconnecting element and the second interlocking element matingly corresponds to the first interlocking element. Each ends of the strap member is pivotable around the pivotal connection and lockable at various strap positions with respect to the connectors when the second interlocking element engages the first interlocking element.

Abstract: The present invention generally relates to stabilization straps, and is more specifically concerned with a helmet stabilization strap apparatus. The stabilization strap apparatus provides connectors so configured and sized as to be mountable on the helmet, and each include a first pivotal interconnecting element and a first interlocking element. The stabilization strap apparatus further includes a strap member having ends connectable to a respective connector. Each of the ends includes a second pivotal interconnecting element and a second interlocking element, such that the second pivotal interconnecting element is mountable in a pivotal connection to the first pivotal interconnecting element and the second interlocking element matingly corresponds to the first interlocking element. Each ends of the strap member is pivotable around the pivotal connection and lockable at various strap positions with respect to the connectors when the second interlocking element engages the first interlocking element.

Abstract: A composition comprising a protein having an inhibitory activity for a serine protease and, in particular, for a serine elastase, the protein having a molecular weight of about 46 kDa in a deglycosylated form, and having a molecular weight of about 54 kDa when isolated in a glycosylated form is provided. Methods of using the protein in treatments of diseases where inhibition of a serine protease and, in particular, of a serine elastase is effective are provided as well as compositions, reagents, and kits related thereto.