Patents by Inventor Denis J. Hartigan-O'Connor

Denis J. Hartigan-O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Helper adenovirus vectors
    Patent number: 6451596
    Abstract: The present invention provides improved adenovirus vectors and packaging cell lines. One type of improved adenoviral vector comprises deletions within the E2b region of the adenoviral genome. These E2b-deleted virus are used in conjunction with novel cell lines that constitutively express E2b gene products. The present invention further provides adenoviral vectors deleted for all viral coding regions. These “gutted” vectors permit the transfer of large genes to cells as demonstrated herein by the transfer of the dystrophin gene to the muscle of mice. The E2b-deleted vectors and the gutted vectors provide improved adenoviral vectors useful for a wide variety of gene therapy applications.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: September 17, 2002
    Assignee: Regents of the University of Michigan
    Inventors: Jeffrey S. Chamberlain, Andrea Amalfitano, Michael A. Hauser, Rajendra Kumar-Singh, Denis J. Hartigan-O'Connor