Patents by Inventor Denis Monard

Denis Monard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of protease nexin 1 inhibitors to reduce metastasis
    Patent number: 8933212
    Abstract: The present invention relates to a method of inhibiting metastasis comprising the administration of an inhibitor of protease nexin-1 (PN-1), characterized in that said inhibitor is administered at a therapeutical dosage that does not completely inhibit the expression and/or activity of PN-1.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: January 13, 2015
    Assignee: Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
    Inventors: Bérengère Fayard, Denis Monard
  • USE OF PROTEASE NEXIN 1 INHIBITORS TO REDUCE METASTASIS
    Publication number: 20100254976
    Abstract: The present invention relates to a method of inhibiting metastasis comprising the administration of an inhibitor of protease nexin-1 (PN-1), characterized in that said inhibitor is administered at a therapeutical dosage that does not completely inhibit the expression and/or activity of PN-1.
    Type: Application
    Filed: December 5, 2008
    Publication date: October 7, 2010
    Inventors: Bérengère Fayard, Denis Monard
  • Protease-activated receptor (par) modulator assays
    Patent number: 7148018
    Abstract: There is provided a method of identifying a PAR cleaving molecule comprising the steps of: (a) providing an immobilized PAR cleavage peptide linked to a reporter molecule; (b) contacting the immobilized PAR cleavage peptide with a PAR cleaving molecule; and (c) detecting release of the reporter molecule.
    Type: Grant
    Filed: December 13, 2000
    Date of Patent: December 12, 2006
    Assignee: Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute for Biomedical Research
    Inventors: Ludger Altrogge, Denis Monard
  • Methods and reagents for protease inhibition
    Publication number: 20060177432
    Abstract: The invention discloses a protease inhibitor and a method of inhibiting a protease selected from the group consisting of thrombin, chymotrypsin and neuropsin, by contacting the protease with an effective amount of a member of the phosphoethanolamine binding protein (PEBP) family.
    Type: Application
    Filed: December 19, 2005
    Publication date: August 10, 2006
    Inventors: Hugo Albrecht, Ulrich Hengst, Denis Monard
  • Methods and reagents for protease inhibition
    Patent number: 7029877
    Abstract: There is provided a protease inhibitor and a method of inhibiting a protease selected from the group consisting of thrombin, chymotrypsin and neuropsin, by contacting the protease with an effective amount of a member of the phosphoethanolamine binding protein (PEBP) family.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: April 18, 2006
    Assignee: Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Instittue for Biomedical Research
    Inventors: Hugo Albrecht, Ulrich Hengst, Denis Monard
  • Methods and reagents for protease inhibition
    Publication number: 20050037009
    Abstract: There is provided a protease inhibitor and a method of inhibiting a protease selected from the group consisting of thrombin, chymotrypsin and neuropsin, by contacting the protease with an effective amount of a member of the phosphoethanolamine binding protein (PEBP) family.
    Type: Application
    Filed: August 30, 2001
    Publication date: February 17, 2005
    Inventors: Hugo Albrecht, Ulrich Hengst, Denis Monard
  • Screening method for compounds that modulate neuronal activity
    Publication number: 20050019261
    Abstract: Animal models and screening methods are provided useful for the identification of modulators of neuronal activity and plasticity, as well as for diagnostic purposes. The methods are based on the use of a serine protease inhibitor, in particular PN-1, as an indicator of neuronal activity.
    Type: Application
    Filed: November 29, 2002
    Publication date: January 27, 2005
    Inventors: Hugo Albrecht, Mirna Kvajo, Denis Monard
  • Protease-activated receptor (par) modulator assays
    Publication number: 20030148921
    Abstract: There is provided a method of identifying a PAR cleaving molecule comprising the steps of: (a) providing an immobilized PAR cleavage peptide linked to a reporter molecule; (b) contacting the immobilized PAR cleavage peptide with a PAR cleaving molecule; and (c) detecting release of the reporter molecule.
    Type: Application
    Filed: October 9, 2002
    Publication date: August 7, 2003
    Inventors: Ludger Altrogge, Denis Monard
  • Method of treating lesions in a nervous system
    Patent number: 5656596
    Abstract: The invention relates to a neurite-promoting factor released by glial cells, to related proteins and fragments thereof retaining their neurite-promoting activity, to DNAs coding for the amino acid sequence of the neurite-promoting factor and fragments thereof, to hybrid vectors containing such DNAs, to hosts transformed with such a hybrid vector, to processes for the preparation of the DNAs, vectors and transformed hosts, to processes for the manufacture of the neurite-promoting factor, related proteins and its fragments, and to their use in the treatment of lesions in the nervous system.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: August 12, 1997
    Assignee: Incyte Pharmaceuticals, Inc.
    Inventors: Denis Monard, Karel Gerrit Odink, Sergio Gloor