Patents by Inventor Denise A Hollman-Hewgley

Denise A Hollman-Hewgley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for generating an image of a biological sample
    Patent number: 11573235
    Abstract: A method for generating an image of a region of interest in a biological sample comprising the steps of: generating a first image including the region of interest of the biological sample having undergone a first protocol but not a second protocol; and generating a second image including the region of interest of the biological sample after having undergone a second protocol; wherein the region of interest is smaller than said sample. Also provided is a method of analyzing a biological sample, comprising providing an image of the biological sample according to the method for generating an image of a region of interest in a biological sample, and analyzing the biological sample from the image. Further provided are system and kit that comprise the means for executing the novel methods.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: February 7, 2023
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Antti E. Seppo, Fiona Ginty, Kevin B. Kenny, David Lavan Henderson, Michael J. Gerdes, Adriana Ines Larriera, Xiaofeng Liu, Alex D. Corwin, Stephen E. Zingelewicz, Thomas Ha, Natalia R. Jun, Ainura Kyshtoobayeva, Denise A. Hollman-Hewgley, Ying Li
  • MULTIPLEXED METHOD FOR DIAGNOSING CLASSICAL HODGKIN LYMPHOMA
    Publication number: 20150226743
    Abstract: A method of analyzing a biological sample suspected of having classic Hodgkin lymphoma, comprising (1) detecting, in a single sample, for the expression of at least two biomarkers selected from CD30, CD15, CD20, CD45, CD3, Pax-5, CD79A, BOB1 and OCT-2; and (b) analyzing the sample based on the presence, absence and/or expression level of the at least two biomarkers. Also provided is a method wherein all the nine biomarkers are analyzed on a single sample. Further provided are method for diagnosing classical Hodgkin lymphoma, as well as system and kit that comprise the means for executing the novel methods.
    Type: Application
    Filed: May 30, 2013
    Publication date: August 13, 2015
    Applicant: CLARIENT DIAGNOSTICS SERVICES, INC.
    Inventors: Lawrence M. Weiss, Rodney A. Beck, Lakshmi Sireesha Kaanumalle, Antti E. Seppo, David Lavan Henderson, Alex David Corwin, Kevin Bernard Kenny, Colin Craig Mcculloch, Fiona Ginty, Alexanderr G. Bordwell, Michael S. Lazare, Denise A. Hollman-Hewgley
  • MULTIPLEXED ASSAY METHOD FOR LUNG CANCER CLASSIFICATION
    Publication number: 20150141278
    Abstract: A method for providing a composite image of a single biological sample from a patient suspected of having lung cancer, comprising the steps of generating a first image of the biological sample, generating a second image of the biological sample, and generating a composite image that provides the relative location of both the targeted proteins. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein of interest from the composite image. Further provided are method for classification of lung cancer, as well as system and kit that comprise the means for executing the novel methods.
    Type: Application
    Filed: May 28, 2013
    Publication date: May 21, 2015
    Applicant: CLARIENT DIAGNOSTIC SERVICES, INC.
    Inventors: Denise A Hollman-Hewgley, Rodney A Beck, Brian Z Ring, Lakshmi Sireesha Kaanumalle
  • MULTIPLEXED DIAGNOSIS METHOD FOR CLASSICAL HODGKIN LYMPHOMA
    Publication number: 20150105283
    Abstract: A method for providing a composite image of a single biological sample from a patient suspected of having classical Hodgkin lymphoma, comprising the steps of generating a first image of the biological sample including the presence, absence and/or expression level of a first biomarker, generating a second image of the biological sample including the presence, absence and/or expression level of a second biomarker, and generating a composite image that provides the relative location or expression of both biomarkers. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the biomarkers of interest from the composite image. Further provided are method for diagnosing classical Hodgkin lymphoma, as well as system and kit that comprise the means for executing the novel methods.
    Type: Application
    Filed: May 30, 2013
    Publication date: April 16, 2015
    Applicant: CLARIENT DIAGNOSTICS SERVICES, INC.
    Inventors: Lawrence M. Weiss, Rodney A. Beck, Lakshmi Sireesha Kaanumalle, Antti E. Seppo, David Lavan Henderson, Alex David Corwin, Kevin Bernard Kenny, Colin Craig McCulloch, Fiona Ginty, Alexanderr G. Bordwell, Michael S. Lazare, Denise A. Hollman-Hewgley
  • IMMUNOFLUORESCENCE AND FLUORESCENT-BASED NUCLEIC ACID ANALYSIS ON A SIMGLE SAMPLE
    Publication number: 20150065371
    Abstract: A method for providing a composite image of a single biological sample, comprising the steps of generating a first image of the biological sample, generating a second image of the biological sample, and generating a composite image that provides the relative location of both the target protein and the target nucleic acid. Also provided is a method of analyzing a biological sample, comprising providing a composite image of the biological sample according to the method for providing a composite image, and analyzing the expression of the protein and the nucleic acid sequences of interest from the composite image. Further provided are system and kit that comprise the means for executing the novel methods.
    Type: Application
    Filed: March 21, 2013
    Publication date: March 5, 2015
    Applicant: CLARIENT DIAGNOSTIC SERVICES, INC.
    Inventors: Antti E. Seppo, Fiona Ginty, Kevin B. Kenny, David Lavan Henderson, Michael J. Gerdes, Adriana I. Larriera Moreno, Xiaofeng Liu, Alex D. Corwin, Stephen E. Zingelewicz, Thomas Ha, Natalie R. Jun, Ainura Kyshtoobayeva, Denise A. Hollman-Hewgley, Ying Li
  • METHODS FOR GENERATING AN IMAGE OF A BIOLOGICAL SAMPLE
    Publication number: 20150050650
    Abstract: A method for generating an image of a region of interest in a biological sample comprising the steps of: generating a first image including the region of interest of the biological sample having undergone a first protocol but not a second protocol; and generating a second image including the region of interest of the biological sample after having undergone a second protocol; wherein the region of interest is smaller than said sample. Also provided is a method of analyzing a biological sample, comprising providing an image of the biological sample according to the method for generating an image of a region of interest in a biological sample, and analyzing the biological sample from the image. Further provided are system and kit that comprise the means for executing the novel methods.
    Type: Application
    Filed: March 21, 2013
    Publication date: February 19, 2015
    Applicant: CLARIENT DIAGNOSTIC SERVICES, INC.
    Inventors: Antti E Seppo, Fiona Ginty, Kevin B Kenny, David Lavan Henderson, Michael J Gerdes, Dariana I Larriera Moreno, Xiaofeng Liu, Alex D Corwin, Stephen E Zingelewicz, Thomas Ha, Natalie R Jun, Ainura Kyshtoobayeva, Denise A Hollman-Hewgley, Ying Li