Abstract: The invention provides a nucleic acid vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order comprising a nucleic acid vaccine vector comprising a suitable eukaryotic cis-acting transcription/translation regulatory sequence functionally linked to a nucleic acid encoding an immunogenic avian polyomarvirus polypeptide. Methods for preventing avian polyomarvirus infection in a bird classified as being a member of the Psittaciformes order, are also provided.

Abstract: The present invention provides a vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order which comprises an immunogenic amount of a modified live avian polyomavirus in a pharmaceutically acceptable carrier. Methods are also provided for preventing avian polyomavirus infection in a bird, or in several different species of birds, classified as being a member of the Psittaciformes order, comprising administering a vaccine comprising an immunogenic amount of a modified live avian polyomavirus and a pharmaceutically acceptable carrier. A preferred embodiment provides a modified live avian polyomavirus vaccine for prevention of wild-type infection in a Budgerigar, lovebird or Cockatiel.