Patents by Inventor Dennis G. Fry

Dennis G. Fry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20190070251
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: April 28, 2017
    Publication date: March 7, 2019
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • WATER-SOLUBLE POLYMER-LINKED BINDING MOIETY AND DRUG COMPOUNDS
    Publication number: 20190030182
    Abstract: Compounds comprising a binding moiety, water-soluble, non-peptidic polymer, and drug are provided. Also provided are methods preparing such compounds, compositions comprising such compounds and methods for administering and using such compounds and compositions.
    Type: Application
    Filed: October 2, 2018
    Publication date: January 31, 2019
    Inventors: Jennifer Riggs-Sauthier, Deborah H. Charych, Clark Norman Eid, JR., Dennis G. Fry, Marina Konakova, Christine Frances Loehrlein
  • METHOD FOR PREDICTING AND EVALUATING RESPONSIVENESS TO CANCER TREATMENT WITH DNA-DAMAGING CHEMOTHERAPEUTIC AGENTS
    Publication number: 20180095085
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Application
    Filed: December 7, 2017
    Publication date: April 5, 2018
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darren W. Davis
  • Method for predicting and evaluating responsiveness to cancer treatment with DNA-damaging chemotherapeutic agents
    Patent number: 9863949
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: January 9, 2018
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darren W. Davis
  • Polymer conjugates of therapeutic peptides
    Patent number: 9682153
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 20, 2017
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • Conjugates of small-interfering nucleic acids
    Patent number: 9433684
    Abstract: The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: September 6, 2016
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Timothy A. Riley, Sean M. Culbertson, Antoni Kozlowski, Dennis G. Fry, Xuejun Yuan, Dawei Sheng, Vidula R. Dixit
  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20160022828
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: March 20, 2015
    Publication date: January 28, 2016
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • Complexes of small-interfering nucleic acids
    Patent number: 9089610
    Abstract: The present invention relates to complexes of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: July 28, 2015
    Assignee: Nektar Therapeutics
    Inventors: Samuel P. McManus, Timothy A. Riley, Sean M. Culbertson, Antoni Kozlowski, Dennis G. Fry, Patrick D. Youso
  • METHOD FOR PREDICTING AND EVALUATING RESPONSIVENESS TO CANCER TREATMENT WITH DNA-DAMAGING CHEMOTHERAPEUTIC AGENTS
    Publication number: 20140357659
    Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 4, 2014
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Ute Hoch, Christine Taylor Brew, Stephen David Harrison, Dennis G. Fry, Darin W. Davis
  • Water-Soluble Polymer-Linked Binding Moiety and Drug Compounds
    Publication number: 20140088021
    Abstract: Compounds comprising a binding moiety, water-soluble, non-peptidic polymer, and drug are provided. Also provided are methods preparing such compounds, compositions comprising such compounds and methods for administering and using such compounds and compositions.
    Type: Application
    Filed: May 24, 2012
    Publication date: March 27, 2014
    Applicant: Nektar Therapeutics
    Inventors: Jennifer Riggs-Sauthier, Deborah H. Charych, Clark Norman Eid, Dennis G. Fry, Marina Konakova, Christine Frances Loehrlein
  • CONJUGATES PF SMALL-INTERFERING NUCLEIC ACIDS
    Publication number: 20120100096
    Abstract: The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
    Type: Application
    Filed: August 19, 2008
    Publication date: April 26, 2012
    Applicant: Nektar Therapeutics
    Inventors: Samuel P. McManus, Timothy A. Riley, Sean M. Culbertson, Antoni Kozlowski, Dennis G. Fry, Xuejun Yuan, Dawei Sheng, Vidula R. Dixit
  • POLYMER CONJUGATES OF AOD-LIKE PEPTIDES
    Publication number: 20110237524
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: September 29, 2011
    Applicant: Nektar Therapeutics
    Inventors: Cherie F. Ali, Dennis G. Fry, Mary J. Bossard, Steven O. Roczniak
  • Complexes of Small-Interfering Nucleic Acids
    Publication number: 20110213013
    Abstract: The present invention relates to complexes of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
    Type: Application
    Filed: August 19, 2009
    Publication date: September 1, 2011
    Applicant: Nektar Therapeutics
    Inventors: Samuel P. McManus, Timothy A. Riley, Sean M. Culbertson, Antoni Kozlowski, Dennis G. Fry, Patrick D. Youso
  • POLYMER CONJUGATES OF OPIOID GROWTH FACTOR PEPTIDES
    Publication number: 20110171165
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 14, 2011
    Inventors: Dennis G. Fry, Christine Taylor Brew, Steven O. Roczniak, Xiaofeng Liu
  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20110166063
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 7, 2011
    Applicant: Nektar Therapeutics
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • POLYMER CONJUGATES OF C-PEPTIDES
    Publication number: 20110165112
    Abstract: The invention provides pro insulin c-peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 7, 2011
    Applicant: Nektar Therapeutics
    Inventors: Mary J. Bossard, Dennis G. Fry, Steven O. Roczniak, Cherie F. Ali, Haim Moskowitz
  • Cell line and uses thereof
    Patent number: 7252992
    Abstract: The subject invention relates to a novel cell line, referred to as T42402I3.4.2, and to uses of this cell line. For example, the cell line may be used in the production of recombinant melanin concentrating hormone (MCH) receptor protein and in the identification of antagonists, inverse agonists and agonists to the receptor.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: August 7, 2007
    Assignee: Abbott Laboratories
    Inventors: Dennis G. Fry, Christine Ann Collins, Brian D. Dayton
  • Cell line and uses thereof
    Publication number: 20040259194
    Abstract: The subject invention relates to a novel cell line, referred to as T42402I3.4.2, and to uses of this cell line. For example, the cell line may be used in the production of recombinant melanin concentrating hormone (MCH) receptor protein and in the identification of antagonists, inverse agonists and agonists to the receptor.
    Type: Application
    Filed: June 17, 2003
    Publication date: December 23, 2004
    Inventors: Dennis G. Fry, Christine Ann Collins, Brian D. Dayton