Abstract: Provided herein are nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs); RNA exon editing molecules) capable of correcting mutations in the ABCA4 gene. Such molecules are useful in the treatment of disorders such as ABCA4-associated retinal dystrophies (e.g., Stargardt Disease or cone-rod dystrophy). Also described herein are methods of using the nucleic acid trans-splicing molecules described herein to correct mutations in ABCA4, thereby treating disorders associated with mutations in ABCA4 and use of the nucleic acid trans-splicing molecules described herein for treating disorders associated with mutations in ABCA4 and in the preparation of medicaments for the treatment of disorders associated with mutations in ABCA4.

Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methyl butenol synthases and their use in methyl butenol production.

Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methyl butenol synthases and their use in methyl butenol production.

Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.

Abstract: A method of performing a static gel strength test on a composition can include placing the composition into a static gel strength test instrument, stirring the composition with at least one helical blade of the instrument, and measuring resistance to rotation between a stator and a rotor of the instrument. A static gel strength test instrument can include a rotor, and a stator having at least one helical blade. The static gel strength test instrument characterizes gelation of a composition. Another static gel strength test instrument can include a stator having at least one helical blade, and a rotor having at least one helical blade.

Abstract: A device for testing the amount of free fluid in a colloid comprises: a first container, wherein the first container has a central axis that spans the length of the first container, wherein the length of the first container is greater than the width and height of the first container, and wherein the central axis of the first container is oriented in a substantially horizontal position during the testing. Methods of using the device include: optically determining the height of free fluid in the container after the period of time has elapsed and using a formula to determine the volume of the free fluid; or removing a plug from a plug tube that is operationally connected to the container; and draining the free fluid from the container into a measurement device.

Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.

Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.

Abstract: A device for testing the amount of free fluid in a colloid comprises: a first container, wherein the first container has a central axis that spans the length of the first container, wherein the length of the first container is greater than the width and height of the first container, and wherein the central axis of the first container is oriented in a substantially horizontal position during the testing. Methods of using the device include: optically determining the height of free fluid in the container after the period of time has elapsed and using a formula to determine the volume of the free fluid; or removing a plug from a plug tube that is operationally connected to the container; and draining the free fluid from the container into a measurement device.

Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.

Abstract: A gate valve has a body, the body having a cavity and a flow passage intersecting the cavity. A seat is mounted to the body at the intersection of the flow passage and the cavity. A gate is installed at the cavity and has an engaging face that slidingly engages the seat while the gate is being moved between open and closed positions. The end faces between a seat pocket and the seat are hard-coated and smooth-finished to provide sealing when mated. The hardcoated pocket and seat sealing surfaces extend the life of the valve by eliminating the need for an elastomeric seal of limited life.

Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.

Abstract: A system for measuring one or more physical properties of cementitious material is operable to cure a slurry of cementitious material under desired conditions of temperature and pressure. Particularly, the system may be operable to cure the slurry under a temperature and pressure expected to be experienced downhole. The system may also be used to determine properties of the cured cementitious material, such as maximum yield strength and shear bond strength at the desired temperature and pressure. The desired conditions of temperature and pressure may be applied both during curing and testing of the cementitious material.

Abstract: A method of performing a static gel strength test on a composition can include placing the composition into a static gel strength test instrument, stirring the composition with at least one helical blade of the instrument, and measuring resistance to rotation between a stator and a rotor of the instrument. A static gel strength test instrument can include a rotor, and a stator having at least one helical blade. The static gel strength test instrument characterizes gelation of a composition. Another static gel strength test instrument can include a stator having at least one helical blade, and a rotor having at least one helical blade.

Abstract: A gate valve has a body, the body having a cavity and a flow passage intersecting the cavity. A seat is mounted to the body at the intersection of the flow passage and the cavity. A gate is installed at the cavity and has an engaging face that slidingly engages the seat while the gate is being moved between open and closed positions. The end faces between a seat pocket and the seat are hard-coated and smooth-finished to provide sealing when mated. The hardcoated pocket and seat sealing surfaces extend the life of the valve by eliminating the need for an elastomeric seal of limited life.

Abstract: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.

Abstract: A system for measuring one or more physical properties of cementitious material is operable to cure a slurry of cementitious material under desired conditions of temperature and pressure. Particularly, the system may be operable to cure the slurry under a temperature and pressure expected to be experienced downhole. The system may also be used to determine properties of the cured cementitious material, such as maximum yield strength and shear bond strength at the desired temperature and pressure. The desired conditions of temperature and pressure may be applied both during curing and testing of the cementitious material.

Abstract: A process for providing a protective layer to an article. The process includes depositing a layer of material onto a surface of the article with a thermal spray process. Examples of thermal spray process include high velocity oxygen/air fuel, atmospheric plasma spray, and chemical vapor deposition. Coating methods, such as cold vapor deposition and physical vapor deposition, may also be used. The layer can then be bonded to the article by heating material in the layer adjacent its connection with the article.

Abstract: This invention is a device for transforming the energy of flowing water into useable energy. At a minimum, the device comprises one or more flow diversion structures, one or more paddle wheels, and one or more generators. A gearbox or transmission may be added to increase the rotational speed of the generators. A subsea cable may be included to transmit the electrical energy produced to shore. Other elements may be added as described by the claims of this patent application.

Abstract: Cement is conditioned, cured and/or tested while applying a specified temperature and/or pressure. In certain embodiments, the specified temperature and/or pressure applied during the testing substantially simulates anticipated static downhole conditions the cement will be subjected to in use. In certain embodiments, the specified temperature and/or pressure applied during the receiving substantially simulates pumping placement conditions the cement will be subjected to in use. In certain embodiments, the cement can be conditioned in a conditioning vessel while applying specified temperature and/or pressure to the cement. In certain embodiments, the temperature and/or pressure applied in the conditioning substantially simulates anticipated pumping placement conditions the cement will be subjected to in use.