Patents by Inventor Dennis Hlasta

Dennis Hlasta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of synthesis of azole-containing amino acids
    Publication number: 20070004728
    Abstract: The invention relates to methods of synthesizing 2-substituted azole compunds of formula (I): The invention is also relates to compounds of formula (I) and to intermediate compounds in the synthesis method.
    Type: Application
    Filed: June 29, 2005
    Publication date: January 4, 2007
    Inventors: Dennis Hlasta, Craig Zificsak
  • Method for synthesis of substituted azole libraries
    Patent number: 6951948
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) wherein X, R2 and the ring components are as described herein, novel intermediates useful for synthesizing such substituted azole compounds and methods for identifying and isolating the compounds.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: October 4, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Yijun Deng, Dennis Hlasta
  • Method of producing highly functionalized 1,3-diamino-propan-2-ols from solid support
    Publication number: 20050124001
    Abstract: The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
    Type: Application
    Filed: December 7, 2004
    Publication date: June 9, 2005
    Inventors: Steve Coats, Dennis Hlasta, Mark Schulz
  • Method for synthesis of substituted azole libraries
    Patent number: 6683191
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) wherein X, R2 and the ring components are as described herein, novel intermediates useful for synthesizing such substituted azole compounds and methods for identifying and isolating the compounds.
    Type: Grant
    Filed: May 22, 2001
    Date of Patent: January 27, 2004
    Assignee: Ortho-McNeil Pharmaceuticals, Inc.
    Inventors: Yijun Deng, Dennis Hlasta
  • Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
    Publication number: 20030171366
    Abstract: Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: 1
    Type: Application
    Filed: January 10, 2002
    Publication date: September 11, 2003
    Inventors: Steven Paget, Dennis Hlasta
  • Ketolide antibacterials
    Patent number: 6590083
    Abstract: The present invention includes compounds of the formula wherein: X is hydrogen or halide; R2 is hydrogen, acyl, or a hydroxy protecting group; R6 is hydrogen, hydroxyl, or —ORa wherein Ra is a substituted or unsubstituted moiety selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl; R13 is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of methyl; C3-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heterocyclo, aryl(C1-C10)alkyl, aryl(C2-C10)alkenyl, aryl(C2-C10)alkynyl, heterocyclo(C1-C10)alkyl, heterocyclo(C2-C10)alkenyl, and heterocyclo(C2-C10)alkynyl; and, R is hydrogen or a substituted or unsubstituted moiety wherein the moiety is selected from the group consisting of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroc
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: July 8, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Dennis Hlasta, Todd C. Henninger, Eugene B. Grant, Chaitin Khosla, Daniel T. W. Chu, Gary Ashley
  • Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
    Patent number: 6518285
    Abstract: Piperidinyloxy, pyrrolidinyloxyl and azetidinyloxy compounds of the formula: wherein R1 is a piperidinyl, pyrrolidinyl or azetidinyl moiety as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: February 11, 2003
    Assignee: Ortho McNeil Pharmaceutical, Inc.
    Inventors: Michele A. Weidner-Wells, Christine Boggs, Dennis Hlasta, Erin Nelson
  • Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
    Publication number: 20020103377
    Abstract: Piperidinyloxy, pyrrolidinyloxyl and azetidinyloxy compounds of the formula: 1
    Type: Application
    Filed: December 5, 2000
    Publication date: August 1, 2002
    Inventors: Michele A. Weidner-Wells, Christine Boggs, Dennis Hlasta, Erin Nelson
  • Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
    Patent number: 6413981
    Abstract: Bicyclic heterocyclic substituted phenyl oxazolidinone compounds of the formula: wherein Y is a radical of the formulae II or III: in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: July 2, 2002
    Assignee: Ortho-McNeil Pharamceutical, Inc.
    Inventors: Steven Paget, Dennis Hlasta
  • Method for synthesis of substituted azole libraries
    Publication number: 20020077483
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) 1
    Type: Application
    Filed: May 22, 2001
    Publication date: June 20, 2002
    Inventors: Yijun Deng, Dennis Hlasta
  • Method for synthesis of substituted azole libraries
    Publication number: 20020042520
    Abstract: The invention relates to methods of synthesizing libraries of diverse and complex 2-substituted azole compounds of the general formula (I) or (II) 1
    Type: Application
    Filed: May 22, 2001
    Publication date: April 11, 2002
    Inventors: Yijun Deng, Dennis Hlasta
  • N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
    Patent number: 6297242
    Abstract: N-substituted amidine and guanidine oxazolidinone compounds of the formula: in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: October 2, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: Dennis Hlasta