Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: Computerized methods and systems in a clinical computing environment are provided for methods and systems in a clinical computing environment for collectively ordering recurring orders. Each treatment period (that is, each instance of a recurring order or group of orders) is permitted to be activated independently even though the ordering activity for the treatment schedule takes place only once. Relationships between orders within a recurring group or phase, as well as relationships between different instances of the group or phase (e.g., between treatment periods included in a treatment schedule wherein the same group of orders is to be executed on two different days) are established utilizing time offsets. Each time that a treatment period is activated, a new time zero is established and future administration times are calculated utilizing the time offsets with respect to the new time zero.

Abstract: A mounting for a power unit for motor vehicles, comprises a support and a support plate fixed thereto, which may be detached in the case of a collision, whereby the support plate is connected to the support in a number of places. A power unit mounting may be achieved which guarantees a steady deceleration, whereby a separating device is provided, which separates the support plate from the support. The separating device can be a part of the support plate or fixed thereto and is forced between support plate and support in the case of a collision.

Abstract: A mounting for a power unit (4) for motor vehicles, comprises a support (12) and a support plate (13) fixed thereto, which may be detached in the case of a collision, whereby the support plate (13) is connected to the support (12) in a number of places (14). According to the invention, a power unit mounting may be achieved which guarantees a steady deceleration, whereby a separating device (25; 55; 65) is provided, which separates the support plate (13) from the support (12). The separating device (25) can be a part of the support plate (13) or fixed thereto and is forced between support plate (13) and support (12) in the case of a collision.