Abstract: A plenum based high-pressure blowback gas delivery system is provided. The system includes a filter vessel, divided into two portions, including and inlet and outlet for fluid. The system further includes a plurality of filter elements to filter fluid flowing from the first vessel portion into the second vessel portion. In response to a pressure differential caused by accretion of particulate matter on the filter elements a uniform flow of high-pressure blowback gas is delivered to the filter elements via nozzles attached to plenums contained within the second vessel portion.

Abstract: Methods and systems for easily replacing fluid disbursement devices used in a sanitary bioreactor are presented. The system includes a fluid disbursement device, a tube adapter, a wand adapter. The fluid disbursement device is fixed to the tube adapter. The tube adapter and wand adapter are essentially complementary and are releasably connected. The combined fluid disbursement device and tube adapter unit is easily replaceable during the cleaning and sterilization of the bioreactor. An O-ring, located in an O-ring grove, provides an impermeable boundary between the wand adapter and the tube adapter.

Abstract: A plenum based high-pressure blowback gas delivery system is provided. The system includes a filter vessel, divided into two portions, including and inlet and outlet for fluid. The system further includes a plurality of filter elements to filter fluid flowing from the first vessel portion into the second vessel portion. In response to a pressure differential caused by accretion of particulate matter on the filter elements a uniform flow of high-pressure blowback gas is delivered to the filter elements via nozzles attached to plenums contained within the second vessel portion.