Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: A method for measuring pressure includes securing a flow channel to a chassis of a measurement device, the flow channel having a flexible wall with a first mechanical engagement feature presented from an external surface thereof. The method also includes engaging the mechanical engagement feature with a complementary engagement member connected to a force transducer, the securing being effective to immobilize the flow channel relative to the force transducer, and detecting at least one of the position and orientation of the of the flow channel relative to transducer and comparing to at least one of a predefined position and orientation. Further, the method includes generating a signal responsive to the detecting, flowing a fluid through the flow channel, and transmitting forces caused by displacement of the flexible wall through the complementary engagement member to the force transducer. Further, electrical signals are generated responsively to a state of the force transducer.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: A pressure measurement pod for use in blood circuits includes a pressure sensing pod defining a chamber and having a rigid wall portion and an integral flexible wall portion forming a flexible, moveable, fluid-impermeable diaphragm with a first major side thereof facing an interior of the chamber and a second major side opposite the first major side. The second major side faces outwardly away from the chamber, and the pod has ports on sides of the chamber. The internal surfaces of the chamber and ports are shaped such that any contour following the internal surfaces to the outside of one of the ports traces only surfaces characterized by positive or neutral draft angles such that invasive mold portions may be withdrawn through the ports thereby permitting the pressure measurement pod to be molded in a single shot molding process.

Abstract: A medical treatment device is configured to be used during a treatment session at a first location and includes a medical treatment component configured to perform at least one of hemodialysis, hemofiltration, and peritoneal dialysis on a patient during the treatment session at the first location. The device also includes a monitoring system configured to receive data from one or more sensors connected to the monitoring system, and to confirm a presence of an authorized helper at the first location. A user interface permits an operator to control functions of the medical treatment component and the monitoring system is configured to perform the presence confirmation automatically and at the predefined time intervals during the treatment session. The monitoring system is also configured to generate an alarm and to cause the medical treatment component to go into a failsafe operational mode.

Abstract: A treatment system for performing a treatment on a patient may include a treatment fluid preparation device having a pump connected by a fluid channel to a reservoir of a source fluid, the pump conveying the source fluid from the reservoir, through a filter, and combining the source fluid with a concentrate by pumping the source fluid with the concentrate to form a treatment fluid in a batch container. The treatment fluid preparation device may have a controller that controls a heater, the pump, and a memory. The controller starts the heater to warm the treatment fluid in the batch container at a time that is responsive to the treatment time stored in the memory. The controller also detects a pressure property of the filter to determine its integrity and outputs an indication of a failed batch if the pressure property indicates the integrity of the filter is insufficient.

Abstract: A treatment device system includes a treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a therapeutic fluid by mixing purified water and at least one concentrate. The system also includes a water purifier with an internal central controller, in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, the controller of the treatment machine transmitting data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: A treatment device system includes a treatment machine for generating a custom dialysis solution and including at least one fluid conveyor, the treatment machine having a controller, the controller having a first memory, configured to produce the custom dialysis solution by causing the at least one fluid conveyor to mix purified water and at least one concentrate. The system also includes a user interface and a water purifier in fluid communication with and providing the purified water to the treatment machine, the water purifier including an internal central controller, the internal central controller having a second memory, to control preparation of the purified water. A server is communicatively coupled with the treatment machine and a control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier.

Abstract: A treatment device system includes a peritoneal dialysis treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a peritoneal dialysis solution by mixing purified water and at least one concentrate. The system also includes a water purifier in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, wherein the controller of the treatment machine transmits data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: A method of controlling flow through a flexible tube includes providing a pinch clamp mechanism including a pinching element and a pinching surface configured to apply a force on the flexible tube when the flexible tube is positioned between the pinching element and the pinching surface. The method also includes displacing the pinching element relative to the pinching surface with a mechanical drive unit and biasing the pinching element toward the pinching surface with a spring.

Abstract: A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.

Abstract: A peritoneal dialysis device includes a disposable tubing set that includes a fill line with a patient access connector at one end and a dialysis fluid receiving end opposite the patient access connector end. The device also includes a fill-side pressure measuring sensor attached at the fill end and forming a disposable component of the tubing set and a patient-side pressure measuring sensor located at the fluid receiving end. The patient-side and fill-side pressure measuring sensors are adapted for measuring pressure in the fill line at the respective ends thereof. The device also includes a controller configured to regulate a rate of flow in the fill line responsively to a signal from the at least the patient-side pressure measuring sensor.

Abstract: A tube clamp closes a flexible tube by applying a pinching force to walls of the flexible tube. The clamp includes a housing connected to a circular flange, the circular flange including a tubular wall surrounding a central bore and including at least one slot in the tubular wall sized to accept the flexible tube. A pinching element is positioned inside the central bore and is rotatable about a central axis of the circular flange. The pinching element includes a pinching projection that has a cross-sectional shape bound by a partial circle, and the partial circle has a radius substantially same as an inner radius of the tubular wall.

Abstract: A treatment device system includes a treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a therapeutic fluid by mixing purified water and at least one concentrate. The system also includes and a water purifier in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, wherein the controller of the treatment machine transmits data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: A treatment device system includes a treatment machine for performing a therapy on a patient, the treatment machine including at least one fluid conveyor and a controller, the controller having a first memory, to cause the at least one fluid conveyor to produce a therapeutic fluid by mixing purified water and at least one concentrate. The system also includes and a water purifier in fluid communication with and providing the purified water to the treatment machine. A wired or wireless control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier, wherein the controller of the treatment machine transmits data via the control line to the internal central controller of the water purifier for control of the water purifier, the data provided based on at least one of the operator inputs received via the user interface.

Abstract: A treatment device system includes a treatment machine for generating custom peritoneal dialysis solution and including at least one fluid conveyor, the treatment machine having a controller, the controller having a first memory, configured to produce a therapeutic fluid by causing the at least one fluid conveyor to mix purified water and at least one concentrate. The system also includes a user interface and a water purifier in fluid communication with and providing the purified water to the treatment machine, the water purifier including internal central controller, the internal central controller having a second memory, to control preparation of the purified water. A server is communicatively coupled with the treatment machine and a control line provides two way communication between the controller of the treatment machine and the internal central controller of the water purifier.

Abstract: A patient's body temperature measurement may be made by varying the heat transfer dynamics of a fluid exiting the patient's body and fitting parameters of heat transfer configuration to measurements under the varied conditions. Then the input temperature of the patient core can be extracted from the model and a current temperature measurement remote from the patient core and optionally other measurements such as fluid flow rate.

Abstract: A medicament preparation system, according to an embodiment, includes a water purification module and a medicament proportioning module. The system is configured to allow convenient and safe use in a home environment or a critical care environment as well as others affording safety, reliability, and a compact form factor.

Abstract: Peritoneal dialysis admixing and/or treatment devices, methods, and systems are disclosed. The systems, methods, and devices provide high-level guarantees of sterility and employs relatively inexpensive disposable components to provide pumping. Disclosed systems, methods, and devices and features thereof are adapted for point of use generation of medicament. In particular admixing systems that employ independently-replaceable long term concentrate are disclosed. Features are directed to assurance of sterility and accurate admixing of water and concentrate to generate ready-to-use medicaments and other benefits.