Abstract: A one-pot synthesis for preparing an aqueous reactive black mixture includes a) dissolving 2-[(4-aminophenyl)sulfonyl]ethanesulfonic acid (vinyl sulphone parabase ester) in water; b) diazotizing the dissolved vinyl sulphone parabase ester using excess nitrous acid or using excess nitrite and an acid, resulting in a diazonium salt and remaining nitrous acid; c) quenching the remaining nitrous acid with sulfamic acid; d) coupling the diazonium salt of step c) with 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid (H-acid) until the reaction is complete, resulting in Reactive Black 5 (RB 5) and remaining diazonium salt, e) coupling the remaining diazonium salt with 7-acetamido-4-hydroxy-2-naphthalenesulfonic acid (acetyl-J-acid) until the reaction is complete resulting in Reactive Orange 78 (RO 78); and f) obtaining the aqueous reactive black mixture.

Abstract: A one-pot synthesis for preparing an aqueous reactive black mixture includes a) dissolving 2-[(4-aminophenyl)sulfonyl]ethanesulfonic acid (vinyl sulphone parabase ester) in water; b) diazotizing the dissolved vinyl sulphone parabase ester using excess nitrous acid or using excess nitrite and an acid, resulting in a diazonium salt and remaining nitrous acid; c) quenching the remaining nitrous acid with sulfamic acid; d) coupling the diazonium salt of step c) with 4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid (H-acid) until the reaction is complete, resulting in Reactive Black 5 (RB 5) and remaining diazonium salt, e) coupling the remaining diazonium salt with 7-acetamido-4-hydroxy-2-naphthalenesulfonic acid (acetyl-J-acid) until the reaction is complete resulting in Reactive Orange 78 (RO 78); and f) obtaining the aqueous reactive black mixture.

Abstract: The invention provides medical devices comprising improved non-uniform coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.

Abstract: The disclosure provides medical devices comprising improved coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.

Abstract: The disclosure provides medical devices comprising improved coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.

Abstract: The disclosure provides medical devices comprising improved coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.

Abstract: The invention provides medical devices comprising improved non-uniform coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.

Abstract: The disclosure provides medical devices comprising improved coatings for ultrasound detection, which provide optimal ultrasound images. Methods for preparing such devices are also provided.

Abstract: The disclosure relates to a coating for improving the ultrasound visibility of a device, the coating being made of a matrix material comprising at least one contrast agent, wherein the at least one contrast agent is a plurality of gas-filled microparticles. Moreover, this disclosure relates to an ultrasonic contrast agent-containing coating for a device. In addition, the herein-described disclosure relates to a method for preparing a microparticle, a method for preparing a coating, and a method for coating a device as well as the coated device.

Abstract: The invention provides a solution to the above mentioned problem in that it provides a catheter balloon comprising a flexible coating on its outer surface wherein a plurality of microparticles are contained wherein said coating comprises a material selected from the group consisting of poly(N-vinyl-pirrolidone, poly(N-vinyl-pirrolidone-co-butylacrylate), poly(-vinyl pyridine), polyacrylamides, e.g. poly(N-isopropylacrylamide), poly(amido-amines), poly(ethylene imine), poly(ethylene oxide-block-propylene oxide), poly(ethylene oxide-block-propylene oxide-block-ethylene oxide), poly(styrene-block-isobutylene-block-styrene), poly(hydroxystyrene-block-isobutylene-block-hydroxystyrene), polydialkylsiloxanes, polysaccharides, polyacrylates and polyalkylmethacrylates, e.g. polymethylmethacrylate and poly(2-hydroxyethylmethacrylate) and wherein said microparticles comprise a material selected from the group consisting of polyesters, e.g.