Patents by Inventor Dennis R. Carter
Dennis R. Carter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10655104Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within to joint space of diarthrotic joints.Type: GrantFiled: November 25, 2014Date of Patent: May 19, 2020Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Publication number: 20190015211Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: ApplicationFiled: May 16, 2018Publication date: January 17, 2019Applicant: The Board of Trustees of The Leland Stanford Junior UniversityInventors: David MYUNG, Lampros KOURTIS, Laura HARTMANN, Curtis W. FRANK, Stuart B. GOODMAN, Dennis R. CARTER
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Publication number: 20160346089Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: ApplicationFiled: July 8, 2016Publication date: December 1, 2016Inventors: David MYUNG, Lampros KOURTIS, Laura HARTMANN, Curtis W. FRANK, Stuart B. GOODMAN, Dennis R. CARTER
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Patent number: 9387082Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: GrantFiled: February 24, 2014Date of Patent: July 12, 2016Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as Represented by the Department of Veterans AffairsInventors: David Myung, Lampros Kourtis, Laura Hartmann, Curtis W. Frank, Stuart B. Goodman, Dennis R. Carter
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Publication number: 20150079048Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within to joint space of diarthrotic joints.Type: ApplicationFiled: November 25, 2014Publication date: March 19, 2015Inventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Publication number: 20140172098Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: ApplicationFiled: February 24, 2014Publication date: June 19, 2014Inventors: David MYUNG, Lampros KOURTIS, Laura HARTMANN, Curtis W. FRANK, Stuart B. GOODMAN, Dennis R. CARTER
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Patent number: 8679190Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: GrantFiled: March 12, 2012Date of Patent: March 25, 2014Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as Represented by the Department of Veterans AffairsInventors: David Myung, Lampros Kourtis, Laura Hartmann, Curtis W. Frank, Stuart B. Goodman, Dennis R. Carter
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Publication number: 20120232657Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: ApplicationFiled: March 12, 2012Publication date: September 13, 2012Inventors: David Myung, Lampros Kourtis, Laura Hartmann, Curtis W. Frank, Stuart B. Goodman, Dennis R. Carter
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Patent number: 7892799Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage, collagen and bone remodeling by intermittently applied hydrostatic pressure consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The intermittent hydrostatic pressure is applied at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours. The interval loading results in the selective inhibition of matrix degrading enzymes, pro-inflammatory cytokines and chemokines that attract inflammatory cells into the joint cavity and in selective decrease of gene expression of growth factors that are inhibitory to type II collagen expression.Type: GrantFiled: August 30, 2007Date of Patent: February 22, 2011Assignees: The Board of Trustees of the Leland Stanford Junior University, The United States of America as represented by the Department of Veterans AffairsInventors: Robert Lane Smith, Dennis R. Carter, David J. Schurman
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Publication number: 20090176304Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints.Type: ApplicationFiled: July 11, 2008Publication date: July 9, 2009Inventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Publication number: 20090088846Abstract: An arthroplasty device is provided having an interpenetrating polymer network (IPN) hydrogel that is strain-hardened by swelling and adapted to be held in place in a joint by conforming to a bone geometry. The strain-hardened IPN hydrogel is based on two different networks: (1) a non-silicone network of preformed hydrophilic non-ionic telechelic macromonomers chemically cross-linked by polymerization of its end-groups, and (2) a non-silicone network of ionizable monomers. The second network was polymerized and chemically cross-linked in the presence of the first network and has formed physical cross-links with the first network. Within the IPN, the degree of chemical cross-linking in the second network is less than in the first network. An aqueous salt solution (neutral pH) is used to ionize and swell the second network. The swelling of the second network is constrained by the first network resulting in an increase in effective physical cross-links within the IPN.Type: ApplicationFiled: April 17, 2008Publication date: April 2, 2009Inventors: David Myung, Lampros Kourtis, Laura Hartmann, Curtis W. Frank, Stuart B. Goodman, Dennis R. Carter
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Publication number: 20030133915Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints.Type: ApplicationFiled: December 24, 2002Publication date: July 17, 2003Inventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Patent number: 6528052Abstract: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic pressure followed and interrupted by periods of recovery. The application of the intermittent hydrostatic pressure at physiological levels 5-10 MPA for an interval of 4 hours followed by a recovery period up to about 20 hours, said pressure applied to the cartilage cells in vitro, explants of cartilage ex vivo and in vivo to cartilage that remains intact within te joint space of diarthrotic joints.Type: GrantFiled: September 29, 2000Date of Patent: March 4, 2003Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: R. Lane Smith, Dennis R. Carter, David J. Schurman
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Patent number: 6383226Abstract: Novel prostheses, particularly femoral prostheses, are provided. The subject devices are characterized by the presence of a curvilinear collar. Also provided are methods of implanting a prosthesis in a manner sufficient to provide for a pressure profile at the collar interface in which the pressure increases from the endosteal to the periosteal surface of the bone.Type: GrantFiled: June 9, 1998Date of Patent: May 7, 2002Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Dennis R. Carter, Jay A. Mandell, Gary S. Beaupré, David J. Schurman
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Patent number: 5752925Abstract: The invention presents a method and device for increasing the fracture resistance of a bone tissue to a traumatic force. The method includes the step of selecting a nonphysiological impulse force having a location and direction resembling that of the traumatic force, but having a magnitude significantly smaller than the magnitude of the traumatic force. The impulse force is then repeatedly applied to the bone tissue, thereby stimulating the bone tissue to grow bone mass in critical areas where stresses from the traumatic force are largest. A device for applying the method includes an impulse force applicator for repeatedly applying the impulse force and a positioner for positioning the impulse force relative to the bone tissue.Type: GrantFiled: June 12, 1996Date of Patent: May 19, 1998Assignee: Board of Trustees of the Leland Stanford Junior UniversityInventors: Gary S. Beaupre, Dennis R. Carter, Wilson C. Hayes
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Patent number: 4683878Abstract: The present invention comprises an elongated bone fixation plate with a center portion which bridges the fracture site. The central portion has a square cross-sectional shape. Two oppositely directed end portions extend axially from the central portion. The central portion has a width which is substantially less than the width of the end portions of the bone fixation plate. The end portions of the bone fixation plate have a plurality of elongated holes and each end portion tapers in thickness from adjacent the central portion to the outer terminating ends of the fixation plate. The plurality of holes are elongated in nature with each hole having a vertical distal wall and an inclined proximal end wall sloping toward the vertical distal wall. Each end portion has a uniform width and the entire bottom surface of each end portion may be concave in shape so as to provide a complementary mating surface with the fractured bone.Type: GrantFiled: April 29, 1985Date of Patent: August 4, 1987Assignee: Kirschner Medical CorporationInventor: Dennis R. Carter