Abstract: A novel chemical method of labeling plasma proteins, compounds and substances containing proteins with the radionuclides of indium at physiologic pH 6-8 condition producing an efficiently labeled radioactive tracer material suitable for biomedical applications. These radiolabeled protein substances are not denatured by the labeling process but retain their native physiobiological properties. This novel labeling technique provides a simple and rapid means of labeling plasma proteins such as human serum albumin, transferrin, lactoferrin, fibrinogen, and immunoglobulin or antibodies with .sup.111 In or .sup.113m In for scintigraphic imaging which may allow visualization of thrombi, emboli, myocardial infarcts, infectious lesions, tumors or any vascular abnormalities in the body.

Abstract: A novel chemical method of labeling porphyrin compounds, specifically hematoporphyrin derivative (HPD), with the radionuclide Technetium-99m producing a radioactive tracer material suitable for biomedical applications. HPD labeled with .sup.99m Tc is biologically active in vivo and is preferentially taken up by neoplastic tissues. This provides a simple and specific means of visualizing tumors in man or animal by scintigraphic imaging techniques.

Abstract: A novel chemical method of labeling porphyrin compounds, specifically hematoporphyrin derivative (HPD), with the radionuclide .sup.111 In or .sup.113m In producing a radioactive tracer material suitable for biomedical applications. HPD labeled with .sup.111 In or .sup.113m In is biologically active in vivo and is preferentially taken up by tumors. This provides a simple and specific means of localizing and detecting neoplasms in man or in animal by scintigraphic imaging techniques.

Abstract: Sodium bicarbonate and potassium bicarbonate are systemic anticoagulants that when administered internally inhibit blood coagulation in man and in warm-blooded animals. As such, they are useful and effective in the treatment and/or prevention of thromboembolic diseases, myocardial infarction or other conditions associated with high risk of thromboembolism. Sodium bicarbonate is especially useful for preventing clotting of ptient's blood during kidney dialysis and for preserving citrated human or animal whole blood and plasma indefinitely under proper storage conditions.

Abstract: A novel injectable diagnostic composition comprises a fibrinolytic enzyme such as streptokinase-activated human plasmin or human urokinase, a stannous reducing agent and an alkaline sodium citrate reagent prepared and packaged as an instant non-radioactive labeling reagent kit to be used in conjunction with a source of .sup.99m Tc-pertechnetate forming a radioactive tracer material suitable for use in scintigraphic imaging of fibrinogen or fibrin depositions in thromboembolic diseases, in myocardial infarction and in neoplasm.

Abstract: A novel rapid chemical method of labeling exogenous and autologous plasma proteins, other compound and/or substance containing proteins with .sup.99m Tc-Technetium at physiologic pH 7.4 condition, producing a sterile apyrogenic radioactive tracer material which is suitable for biological and medical uses.