Abstract: A composition comprising a high molecular weight, water soluble polymer having a cloud point from about 20 to about 90° C. and at least one carrageenan is provided. The composition may be used as a component of a pharmaceutical dosage form, such as the shell of a dosage form, to provide burst release of active ingredient contained therein.

Abstract: An immediate release tablet is provided. The tablet comprises at least 60 weight % of an active ingredient and powdered wax having a melting point greater than about 90° C. The tablet may advantageously be produced by direct compression. Although the wax is hydrophobic, the tablet has excellent disintegration.

Abstract: A dosage form comprises: (a) at least one active ingredient; (b) a core; and(c) a shell which surrounds the core, wherein the shell is substantially free of pores having a diameter of 0.5-5.0 microns, and the shell comprises a first shell portion and a second shell portion which are compositionally different and the dosage form provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium.

Abstract: A dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface; and (c) a shell which resides upon at least a portion of the core outer surface, wherein at least a portion of the shell is semipermeable, such that the liquid medium diffuses through the semipermeable shell or shell portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium.

Abstract: The invention provides a delayed-pulse controlled release pharmaceutical tablet having:(a) from 20 to 60 wt. % of a low molecular weight hydroxypropyl cellulose having a number average molecular weight of 70,000 to 90,000;(b) from 4 to 10 wt. % of a high molecular weight hydroxypropyl cellulose having a number average molecular weight of 1,100,000 to 1,200,000;(c) a pharmacologically acceptable amount of a medicament; and(d) an inert solid diluent.

Abstract: A controlled release pharmaceutical tablet is disclosed which is based on:(a) a compressed core which contains:(i) a medicament;(ii) at least 23% to 55% by weight, based on the total weight of the core, of a water soluble osmotic agent;(iii) a water soluble pharmaceutically acceptable polymeric binder;(iv) a water-swellable pharmaceutically acceptable polymer;(v) a conventional pharmaceutical excipient; and(b) a membrane coating around said core tablet which consists essentially of:(i) a modified water insoluble pharmaceutically acceptable polymer; and(ii) a pharmaceutically acceptable water soluble polymer.

Abstract: A controlled release pharmaceutical tablet having at least one passageway, said tablet having:(a) a compressed core which comprises:(i) a medicament;(ii) an amount of a water soluble osmotic agent which is effective to cause the medicament to be delivered from said passageway in the presence of aqueous media;(iii) a water-swellable pharmaceutically acceptable polymer; and(b) a membrane coating around said core tablet which comprises a water insoluble pharmaceutically acceptable polymer.

Abstract: A controlled release pharmaceutical tablet is disclosed which is based on:(a) a compressed core which contains:(i) a medicament;(ii) from 5 to 20% by weight of a water soluble osmotic agent based on the total weight of the compressed core;(iii) a water soluble pharmaceutically acceptable polymeric binder;(iv) a conventional pharmaceutical excipient; and(b) a dual layer membrane coating around said core which consists essentially of:(i) a first inner coating layer for sustained release of the medicament, said inner coating layer consisting essentially of a plasticized water insoluble pharmaceutically acceptable polymer and a pharmaceutically acceptable water soluble polymer, and;(ii) a second outer coating layer for immediate release of a medicament, said outer coating layer consisting essentially of an effective amount of a medicament and a water soluble polymer.The controlled release formulation is suitable for the once-a-day administration of medicaments.