Abstract: Instruments, methods, and kits are disclosed for performing fast thermocycling.

Abstract: Provided herein is a recanalization system including (i) a handle located at a proximal end of the system, (ii) a first elongate member, (iii) a second elongate member, the first and second elongate members being movable relative to each other elongate member, and (iv) a recanalization device located at a distal end of the system. The recanalization device includes (i) a first end portion coupled to the first elongate member, (ii) a second end portion coupled to the second elongate member, and (iii) at least one strut extending between the first and second end portions. The recanalization device is configured to be (i) selectively radially expanded and compressed and (ii) axially moved relative to the first and second elongate members.

Abstract: A box erecting device for folding a box is disclosed herein. The box erecting device includes a folding plate and a lid erecting system. The folding plate is configured for erecting a box, and a folding notch including a first edge and a second edge is formed in the folding plate. The first edge is configured for erecting a first dust flap of the box, and the second edge is configured for erecting a second dust flap of the box. The lid erecting system is disposed adjacent to the folding plate and is configured for erecting a lid of the box. The lid erecting system includes a tab funnel and a folding tool. The tab funnel includes a ramp for retaining the dust flaps while closing the lid. The folding tool includes a hooked ramp for causing a distal end of the lid to be inserted into the box.

Abstract: Provided herein are radiopharmaceutical conjugate compositions and uses thereof. In one aspect, provided herein are conjugates that comprise a monocyclic peptide of 5 to 40 amino acid residues and a metal chelator configured to bind with a radionuclide. In some embodiments, the monocyclic peptide is cyclized by a non-disulfide bond. In some embodiments, the monocyclic peptide does not comprise any non-disulfide bond. The monocyclic peptide can be configured to bind with a structure on a cell. Further provided herein are methods of treating cancer by administering the described conjugates and compositions.

Abstract: The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NK1R signalling.

Abstract: The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NK1R signalling.

Abstract: An apparatus and method are provided for optical liquid level determination in a liquid dispensing system. Accurate volume dispensing based on the level determination is also provided. An optical sensor device emits a light signal downward into the tank toward the liquid, and received a portion of the light signal that has been reflected upwardly by a surface at the top of the liquid. A processing system calculates the height of the liquid in the tank based on a time of flight measurement of the light signal. A head pressure of the liquid over a controllable dispensing valve located at the bottom of tank may then be calculated using the calculated height of the liquid in the tank. An open time for the controllable dispensing valve is then calculated, based on the calculated head pressure, in order to dispense a predetermined volume of liquid from the tank.

Abstract: A pinch valve that includes a holder and an insert that fits in the holder. The pinch valve receives a dispensing tube for liquids and controls the flow of liquid in the dispensing valve. The insert defines an inner wall portion against which a plunger assembly pushes the dispensing tube to stop liquid from flowing through the dispensing tube. The insert and the holder define a throttle portion that throttles the flow of liquid when the plunger assembly is moved from the pinch position, where is pushed the dispensing tube against the inner wall portion of the insert, to a flow position.

Abstract: A product case for receiving a fluid bag used in gravity based fluid dispensing systems. The product case has a floor and sidewalls that form a rectangular enclosure for the fluid bag, and a bag supporter in contact with the fluid bag. The bag supporter includes a notch formed in a top edge of one sidewall to facilitate receipt of material of the fluid bag, a slot in the one sidewall extending from a bottom of the triangular shaped notch and configured to receive and retain the material of the fluid bag, and a removable retaining wall held by support structures on a pair of the sidewalls opposing each other to divide the rectangular enclosure into a smaller enclosure. The sidewalls and the removable retaining wall constrain the fluid bag within the smaller enclosure, while the triangular shaped notch and the slot minimizes fluid bag material from covering the outlet nozzle as the fluid bag empties and provides for repeatable flow characteristics for portion control applications.

Abstract: An optical liquid height determination system of the present embodiments includes light sensors capturing different amounts of light, based on level of liquid in the tank that blocks or limits light to particular sensors. The tank is enclosed in a container with a light source and the light sensors are installed on walls of the container. Light emitted by the light source is transmitted to the light sensors by passing through the liquid product, scattered, diffused, diffracted or reflected by the dairy product, through the tank walls which may be transparent or translucent, or from other surfaces in the container within which the tank is enclosed by. The set of electrical signals received from all the light sensors are compared against sets of calibrated signals corresponding to known liquid levels in the tank. The known height corresponding to the nearest set of calibrated signals is determined as the measured liquid height in the tank.

Abstract: A product case for receiving a fluid bag used in gravity based fluid dispensing systems. The product case has a floor and sidewalls that form a rectangular enclosure for the fluid bag, and a bag supporter in contact with the fluid bag. The bag supporter includes a notch formed in a top edge of one sidewall to facilitate receipt of material of the fluid bag, a slot in the one sidewall extending from a bottom of the triangular shaped notch and configured to receive and retain the material of the fluid bag, and a removable retaining wall held by support structures on a pair of the sidewalls opposing each other to divide the rectangular enclosure into a smaller enclosure. The sidewalls and the removable retaining wall constrain the fluid bag within the smaller enclosure, while the triangular shaped notch and the slot minimizes fluid bag material from covering the outlet nozzle as the fluid bag empties and provides for repeatable flow characteristics for portion control applications.

Abstract: A pinch valve has an insert housed in a holder. The insert and the holder are shaped to receive a dispensing tube and the insert can rotate within the holder and around the dispensing tube. The insert can be rotated to have the pinch valve in a release configuration where the insert can be moved downward and out of the holder to allow for cleaning of the insert and holder.

Abstract: The present invention relates to tripartite compounds comprising a modulator moiety for endosomal G protein-coupled receptors like neurokinin-1 receptor, a linker and a lipid anchor suitable for anchoring the tripartite compound into a plasma membrane. The present invention also relates to a prodrug and a pharmaceutical composition comprising the tripartite compound and the use of the tripartite compound for the treatment of a disease or disorder mediated by endosomal G protein-coupled receptors signalling like NK1R signalling.

Abstract: An optical liquid height determination system of the present embodiments includes light sensors capturing different amounts of light, based on level of liquid in the tank that blocks or limits light to particular sensors. The tank is enclosed in a container with a light source and the light sensors are installed on walls of the container. Light emitted by the light source is transmitted to the light sensors by passing through the liquid product, scattered, diffused, diffracted or reflected by the dairy product, through the tank walls which may be transparent or translucent, or from other surfaces in the container within which the tank is enclosed by. The set of electrical signals received from all the light sensors are compared against sets of calibrated signals corresponding to known liquid levels in the tank. The known height corresponding to the nearest set of calibrated signals is determined as the measured liquid height in the tank.

Abstract: A pinch valve for a liquid-dispensing unit or machine has a pinch valve body to which is pivotally secured a closure in a clamshell arrangement. The valve body and the closure define a passageway that can hold a liquid-dispensing tube when the pinch valve is in a closed configuration. The axis about which the closure pivots is perpendicular to the passageway.

Abstract: A pinch valve for a liquid-dispensing unit or machine has a pinch valve body to which is connected a pinch bar assembly. The pinch bar assembly has two axes of rotation and can easily be moved by a user from a pinch position, where the pinch bar is the displacement path of a plunger, to an open position where it is not in the displacement path. A liquid-dispensing tube can be installed in the pinch valve between the pinch bar and the plunger.

Abstract: In one embodiment, a liquid dispenser includes a liquid reservoir, a measurement device providing at least one signal indicative of the amount of liquid remaining in the liquid reservoir, an electrically actuated valve coupled to a tube outlet exiting from a bottom of the liquid reservoir, and a processor. The processor is electrically connected to the measurement device and operatively coupled to and controlling operation of the valve. Further, the processor is configured to determine a valve open time for dispensing a requested amount of liquid. The valve open time depends upon a preliminary time based on the requested amount and at least one signal from the measurement device, and an adjustment to the preliminary time based on a difference between a requested amount and a measured amount determined by the measurement device for at least one previous dispense.

Abstract: A pinch valve that includes a holder and an insert that fits in the holder. The pinch valve receives a dispensing tube for liquids and controls the flow of liquid in the dispensing valve. The insert defines an inner wall portion against which a plunger assembly pushes the dispensing tube to stop liquid from flowing through the dispensing tube. The insert and the holder define a throttle portion that throttles the flow of liquid when the plunger assembly is moved from the pinch position, where is pushed the dispensing tube against the inner wall portion of the insert, to a flow position.

Abstract: A pinch valve has an insert housed in a holder. The insert and the holder are shaped to receive a dispensing tube and the insert can rotate within the holder and around the dispensing tube. The insert can be rotated to have the pinch valve in a release configuration where the insert can be moved downward and out of the holder to allow for cleaning of the insert and holder.

Abstract: A pinch valve for a liquid-dispensing unit or machine has a pinch valve body to which is connected a pinch bar assembly. The pinch bar assembly has two axes of rotation and can easily be moved by a user from a pinch position, where the pinch bar is the displacement path of a plunger, to an open position where it is not in the displacement path. A liquid-dispensing tube can be installed in the pinch valve between the pinch bar and the plunger.