Patents by Inventor Derek RHOADES

Derek RHOADES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of thailanstatin A, methods of treatment and methods of synthesis thereof
    Patent number: 11584754
    Abstract: In one aspect, the present disclosure provides analogs of thailanstatin of the formula wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: February 21, 2023
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C. Nicolaou, Derek Rhoades, Soundarapandian M. Kumar, Manas R. Pattanayak, Manjunath Lamani
  • AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES
    Publication number: 20210238187
    Abstract: In one aspect, the present disclosure provides epothilone analogs of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Application
    Filed: April 11, 2018
    Publication date: August 5, 2021
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Kyriacos C NICOLAOU, Derek RHOADES, Yangping WANG
  • Epothilone analogs, methods of synthesis, methods of treatment, and drug conjugates thereof
    Patent number: 10874646
    Abstract: In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 29, 2020
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C Nicolaou, Derek Rhoades, Yanping Wang, Sotirios Totokotsopoulos
  • DERIVATIVES OF THAILANSTATIN A, METHODS OF TREATMENT AND METHODS OF SYNTHESIS THEREOF
    Publication number: 20200024283
    Abstract: In one aspect, the present disclosure provides analogs of thailanstatin of the formula wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
    Type: Application
    Filed: June 8, 2017
    Publication date: January 23, 2020
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Kyriacos C. NICOLAOU, Derek RHOADES, Soundarapandian M. KUMAR, Manas R. PATTANAYAK, Manjunath LAMANI
  • EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES THEREOF
    Publication number: 20190022069
    Abstract: In one aspect, the present disclosure provides epothilone analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.
    Type: Application
    Filed: October 14, 2016
    Publication date: January 24, 2019
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Kyriacos C NICOLAOU, Derek RHOADES, Yanping WANG, Sotirios TOTOKOTSOPOULOS