Patents by Inventor Derek W. Barnett

Derek W. Barnett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid phase synthesis of arylretinamides
    Patent number: 7550510
    Abstract: A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: June 23, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert W. Curley, Jr., Serena M. Mershon, Derek W. Barnett, Margaret Clagett-Dame, Jason S. Chapman
  • Solid phase synthesis of arylretinamides
    Publication number: 20040102650
    Abstract: A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.
    Type: Application
    Filed: November 21, 2003
    Publication date: May 27, 2004
    Inventors: Robert W. Curley, Serena M. Mershon, Derek W. Barnett, Margaret Clagett-Dame, Jason S. Chapman
  • Solid phase synthesis of arylretinamides
    Publication number: 20030105164
    Abstract: A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.
    Type: Application
    Filed: July 8, 2002
    Publication date: June 5, 2003
    Inventors: Robert W. Curley,, Serena M. Mershon, Derek W. Barnett, Margaret Clagett-Dame, Jason S. Chapman