Patents by Inventor Derk J. W. Klunder
Derk J. W. Klunder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200182794Abstract: The invention discloses a luminescence sensor for bio-sensing having an input reflector and an output reflector. The gap between the input and output reflectors constitutes an optical cavity. One or both of the input and output reflectors can be a wire-grid polarizer having apertures, where at least one dimension of the apertures is below the diffraction limit. When input radiation impinges the input reflector a fraction of the input radiation is transmitted into the cavity. The energy of the radiation inside the cavity is increased due to the resonance properties of the cavity. Due to the increase of the cavity excitation energy, the luminescent radiation emitted from the luminescent particles inside the cavity can be detected outside the cavity. Since the input and output reflectors have high reflection coefficients the input radiation is effectively prohibited from being transmitted through the luminescence detector.Type: ApplicationFiled: December 10, 2018Publication date: June 11, 2020Inventors: DERK J.W. Klunder, Maarten M.J.W. Herpen
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Patent number: 9176062Abstract: A luminescence sensor, comprising a non-transparent substrate structure (2) having at least one aperture (5) intended to comprise an analyte and a transparent substrate structure (3), which is arranged to or adjacent said first structure (2). The aperture has a smallest lateral dimension, which is smaller than half the effective wavelength of an excitation radiation, such as light at a wavelength of 700 nm, resulting in an effective wavelength in water of about 538 nm. The transparent structure has a trench (4) with a surface portion provided with ligands with an affinity towards a target molecule. The trench results in that a luminophore attached to the target molecule will be positioned at the entrance surface of the aperture, where the excitation energy is largest.Type: GrantFiled: December 17, 2007Date of Patent: November 3, 2015Assignee: Koninklijke Philips N.V.Inventors: Derk J. W. Klunder, Maarten M. J. W. Van Herpen, Hendrik R. Stapert
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Patent number: 9134244Abstract: A device for monitoring radiation emitted by luminophores present in an analyte fluid of a wiregrid biosensor. The monitoring device comprises a non-polarized light source (41) for illuminating the wiregrid biosensor for exciting fluorescent labels arranged in the analyte fluid of said biosensor. A detector (71) detects radiation emitted by the labels after excitation. A polarizing filter (53) is arranged in between the transparent substrate and the detector for suppression of background emission radiation from labels positioned outside apertures in the wiregrid, in the analyte fluid.Type: GrantFiled: February 12, 2008Date of Patent: September 15, 2015Assignee: Koninklijke Philips N.V.Inventors: Derk J. W. Klunder, Maarten M. J. W. Van Herpen, Hendrik R. Stapert
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Patent number: 8158398Abstract: An optical device provides evanescent radiation, in response to incident radiation, in a detection volume for containing a target component in a medium. The detection volume has at least one in-plane dimension (W1) smaller than a diffraction limit. The diffraction limit is defined by the radiation wavelength and the medium. The evanescent radiation is provided by aperture defining structures having a smallest in plane aperture dimension (W1) smaller than the diffraction limit. The detection volume is provided between the aperture defining structures. The aperture defining structures further define a largest in plane aperture dimension (W2). The largest in plane aperture dimension is larger than the diffraction limit.Type: GrantFiled: December 18, 2008Date of Patent: April 17, 2012Assignee: Koninklijke Philips Electronics N.V.Inventor: Derk J. W. Klunder
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Patent number: 8075841Abstract: A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed.Type: GrantFiled: December 11, 2006Date of Patent: December 13, 2011Assignee: Koninklijke Philips Electronics N.V.Inventors: Maarten Van Herpen, Dirk J. Broer, Emiel Peeters, Derk J. W Klunder, Hendrik R. Stapert
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Patent number: 8039818Abstract: There is provided a method of detecting a presence of a luminophore in a detection volume comprising providing excitation radiation in said detection volume. A luminophore is provided in said detection volume being excitable by said excitation radiation. The luminescent radiation is detected to identify the presence of said luminophore in said detection volume. In one aspect of the invention, said luminophore is selected to emit luminescent radiation having a wavelength in said medium that is larger than twice said smallest dimension; and wherein said luminophore is selected to be excitable by excitation radiation having a wavelength in said medium that is smaller than twice said smallest dimension. Accordingly, luminescent radiation is blocked from entering the detector but for the portion present on an interface of the aperture.Type: GrantFiled: December 18, 2007Date of Patent: October 18, 2011Assignee: Koninklijke Philips Electronics N.V.Inventors: Maarten M. J. W. Van Herpen, Derk J. W. Klunder
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Publication number: 20110195516Abstract: The present invention relates to a multi-layered substrate structure comprising at least one carrier layer (11), a first layer (12), said carrier layer and first layer being in contact with each other, and at least one second layer with a chemical composition different from the first layer (13) said first and second layer being in contact with each other, the second layer forming apertures each having at least one in-plane dimension (W1) smaller than the diffraction limit, the diffraction limit being defined by a radiation wavelength of the excitation light. The invention further relates to the use and manufacturing process of such a substrate structure and a luminescence sensor.Type: ApplicationFiled: September 8, 2009Publication date: August 11, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Neriman Nicoletta Kahya, Derk J.W. Klunder
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Publication number: 20110039720Abstract: The present invention relates to a process for conducting real-time PCR, and to a device for conducting the method of the present invention. The invention is especially suited for the simultaneous identification and quantification of nucleic acids present in a sample, e.g. a biological sample. Further, this invention describes a method for simultaneous quantitative analysis of multiple nucleic acid sequences in a single compartment by using an integrated nucleic acid microarray combined with a highly surface-specific readout device. The invention relates to a device wherein a surface which is either part of the chamber surface or a surface that is created in the reaction chamber, such as bead surface, is coated with capture probes and in the same chamber, a PCR reaction takes place.Type: ApplicationFiled: December 16, 2008Publication date: February 17, 2011Applicant: BIOCARTIS S.A.Inventors: Erik R. Vossenaar, Derk J. W. Klunder, Hendrik R. Stapert, Henk Van Houten, Bob Van Gemen, Erik M. H. P. Van Dijk
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Publication number: 20100276577Abstract: The invention concerns an optical device for providing evanescent radiation, in response to incident radiation, in a detection volume for containing a target component in a medium, the detection volume having at least one in-plane dimension (W1) smaller than a diffraction limit. The diffraction limit is defined by the radiation wavelength and the medium. The evanescent radiation is provided by aperture defining structures having a smallest in plane aperture dimension W1 smaller than the diffraction limit. The detection volume is provided between said aperture defining structures. The aperture defining structures in addition define a largest in plane aperture dimension W2; wherein said largest in plane aperture dimension is larger than the diffraction limit.Type: ApplicationFiled: December 18, 2008Publication date: November 4, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventor: Derk J.W. Klunder
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Publication number: 20100108908Abstract: A device for monitoring radiation emitted by luminophores present in an analyte fluid of a wiregrid biosensor. The monitoring device comprises a non-polarized light source (41) for illuminating the wiregrid biosensor for exciting fluorescent labels arranged in the analyte fluid of said biosensor. A detector (71) detects radiation emitted by the labels after excitation. A polarizing filter (53) is arranged in between the transparent substrate and the detector for suppression of background emission radiation from labels positioned outside apertures in the wiregrid, in the analyte fluid.Type: ApplicationFiled: February 12, 2008Publication date: May 6, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Derk J.W. Klunder, Maarten M.J.W. Van Herpen, Hendrik R. Stapert
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Publication number: 20100096562Abstract: There is provided a wave guide comprising: a wave guiding medium, having an index of refraction and provided between first and second wave propagating planar structures at least said first planar structure comprises a plurality of slitted-apertures defining a length axis of the first reflective structure; the slitted apertures constructed and arranged to reflect a R-polarized component of said radiation oriented parallel to said length axis; and wherein said first planar structure is arranged between said wave guiding medium and an adjacent medium having an index of refraction equal or larger than the wave guiding medium. In one aspect of the invention, a waveguide is proposed to limit an excitation region wherein luminophores are excited; substantially independent from the surrounding media of the waveguide. Preferentially, the waveguide is used in a luminescence sensor.Type: ApplicationFiled: December 17, 2007Publication date: April 22, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Derk J.W. Klunder, Maarten M.J.W. Van Herpen, Marcus A. Verschuuren
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Publication number: 20100072397Abstract: There is provided a method of detecting a presence of a luminophore in a detection volume comprising providing excitation radiation in said detection volume. A luminophore is provided in said detection volume being excitable by said excitation radiation. The luminescent radiation is detected to identify the presence of said luminophore in said detection volume. In one aspect of the invention, said luminophore is selected to emit luminescent radiation having a wavelength in said medium that is larger than twice said smallest dimension; and wherein said luminophore is selected to be excitable by excitation radiation having a wavelength in said medium that is smaller than twice said smallest dimension. Accordingly, luminescent radiation is blocked from entering the detector but for the portion present on an interface of the aperture.Type: ApplicationFiled: December 18, 2007Publication date: March 25, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Maarten M.J.W. Van Herpen, Derk J.W. Klunder
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Publication number: 20100044585Abstract: The invention discloses a luminescence sensor (101) for bio-sensing having an input reflector (253) and an output reflector (254). The gap (S) between the input and output reflectors constitutes an optical cavity. One or both of the input and output reflectors can be a wire-grid (270) having apertures (211,212), where at least one dimension of the apertures is below the diffraction limit. When input radiation (221) impinges the input reflector a fraction of the input radiation is transmitted into the cavity. The energy of the radiation inside the cavity is increased due to the resonance properties of the cavity. Due to the increase of the cavity excitation energy, the luminescent radiation emitted from the luminescent particles inside the cavity can be detected outside the cavity. Since the input and output reflectors have high reflection coefficients the input radiation is effectively prohibited from being transmitted through the luminescence detector.Type: ApplicationFiled: October 31, 2007Publication date: February 25, 2010Inventors: DERK J.W. Klunder, Maarten M.J.W. Herpen
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Publication number: 20100001210Abstract: A luminescence sensor, comprising a non-transparent substrate structure (2) having at least one aperture (5) intended to comprise an analyte and a transparent substrate structure (3), which is arranged to or adjacent said first structure (2). The aperture has a smallest lateral dimension, which is smaller than half the effective wavelength of an excitation radiation, such as light at a wavelength of 700 nm, resulting in an effective wavelength in water of about 538 nm. The transparent structure has a trench (4) with a surface portion provided with ligands with an affinity towards a target molecule. The trench results in that a luminophore attached to the target molecule will be positioned at the entrance surface of the aperture, where the excitation energy is largest.Type: ApplicationFiled: December 17, 2007Publication date: January 7, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Derk J.W. Klunder, Maarten M.J.W. Van Herpen, Hendrik R. Stapert
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Patent number: 7593617Abstract: An optical waveguide comprises a body (13), the body including an entrance window (9) and an exit window (11) defining an optical path (13) through a cavity. The cavity contains a first fluid (A) and a second fluid (B), with an interface between the first fluid and the second fluid defined by a meniscus. The meniscus lies longitudinally along the optical path. Means for adjusting the meniscus are provided, for example a voltage source and at least two electrodes. Electrowetting can be used for influencing the fluids.Type: GrantFiled: February 15, 2006Date of Patent: September 22, 2009Assignee: Koninklijke Philips Electronics N.V.Inventors: Derk J. W. Klunder, Bernardus H. W. Hendriks, Stein Kuiper
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Publication number: 20090001284Abstract: A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed.Type: ApplicationFiled: December 11, 2006Publication date: January 1, 2009Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Maarten van Herpen, Dirk J. Broer, Emiel Peeters, Derk J.W Klunder, Hendrik R. Stapert
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Publication number: 20080166089Abstract: An optical waveguide comprises a body (13), the body including an entrance window (9) and an exit window (11) defining an optical path (13) through a cavity. The cavity contains a first fluid (A) and a second fluid (B), with an interface between the first fluid and the second fluid defined by a meniscus. The meniscus lies longitudinally along the optical path. Means for adjusting the meniscus are provided, for example a voltage source and at least two electrodes. Electrowetting can be used for influencing the fluids.Type: ApplicationFiled: February 15, 2006Publication date: July 10, 2008Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Derk J.W. Klunder, Bernardus H.W. Hendriks, Stein Kuiper