Patents by Inventor Derrick J. Rossi

Derrick J. Rossi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20180291383
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Application
    Filed: November 20, 2017
    Publication date: October 11, 2018
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • Efficient protein expression in vivo using modified RNA (MOD-RNA)
    Patent number: 10086043
    Abstract: Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: October 2, 2018
    Assignees: THE GENERAL HOSPITAL CORPORATION, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Kenneth R. Chien, Leon M. Ptaszek, Oi-Lan Lui, Lior Zangi, Wataru Ebina, Derrick J. Rossi
  • Hematopoietic stem cell specific reporter mouse and uses thereof
    Patent number: 10080354
    Abstract: Described herein are nucleic acid constructs, hematopoietic stem cell identifier animals, and methods of using thereof for isolating hematopoietic stem cell populations. Also provided are methods of using the identifier animals and cells isolated from them to screen for agents that affect the growth, proliferation, potency, expansion, or maintenance of the stem cells. Such agents can be used for promoting growth of stem cells in vitro or in vivo, and also for inhibiting cancer cells that have been determined to resemble a stem cell.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: September 25, 2018
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Derrick J. Rossi, Roi Gazit
  • METHODS AND COMPOSITIONS RELATING TO HEMATOPOIETIC STEM CELL EXPANSION, ENRICHMENT, AND MAINTENANCE
    Publication number: 20180187156
    Abstract: The methods and compositions described herein relate to producing, expanding, enriching, and/or maintaining hematopoietic stem cells ex vivo by treating the cells with an agent(s) that exhibits two or more activities selected from modulation of histone methylation; inhibition of TGF? signaling; inhibition of p38 signaling; activation of canonical Wnt signaling; and modulation of histone acetylation. In some embodiments, the technology described herein relates to transplantation of hematopoietic stem cells.
    Type: Application
    Filed: June 24, 2016
    Publication date: July 5, 2018
    Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Derrick J. ROSSI, Wataru EBINA, Morag STEWART, Paula GUTIERREZ-MARTINEZ, Lee RUBIN, Lance DAVIDOW
  • Method of making a deletion in a target sequence in isolated primary cells using Cas9 and two guide RNAs
    Patent number: 9822370
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: November 21, 2017
    Assignees: President and Fellows of Harvard College, The Children's Medical Center Corporation
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • HEMATOPOIETIC STEM CELL SPECIFIC REPORTER MOUSE AND USES THEREOF
    Publication number: 20150223436
    Abstract: Described herein are nucleic acid constructs, hematopoietic stem cell identifier animals, and methods of using thereof for isolating hematopoietic stem cell populations. Also provided are methods of using the identifier animals and cells isolated from them to screen for agents that affect the growth, proliferation, potency, expansion, or maintenance of the stem cells. Such agents can be used for promoting growth of stem cells in vitro or in vivo, and also for inhibiting cancer cells that have been determined to resemble a stem cell.
    Type: Application
    Filed: September 6, 2013
    Publication date: August 13, 2015
    Inventors: Derrick J. Rossi, Roi Gazit
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20150176013
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Application
    Filed: October 8, 2014
    Publication date: June 25, 2015
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20150152436
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
    Type: Application
    Filed: October 8, 2014
    Publication date: June 4, 2015
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20150071889
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Application
    Filed: September 12, 2014
    Publication date: March 12, 2015
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • EFFICIENT PROTEIN EXPRESSION IN VIVO USING MODIFIED RNA (MOD-RNA)
    Publication number: 20140073687
    Abstract: Aspects of the invention described herein relate to synthetic, modified RNAs and their use in vivo to modulate gene expression. Aspects of the invention further relate to the use of these synthetic, modified RNAs in myocytes, cardiomyoctes, and tumors.
    Type: Application
    Filed: March 12, 2012
    Publication date: March 13, 2014
    Applicants: IMMUNE DISEASE INSTITUTE, INC., THE GENERAL HOSPITAL CORPORATION
    Inventors: Kenneth R. Chien, Leon M. Ptaszek, Kathy Oi-Lan Lui, Lior Zangi, Wataru Ebina, Derrick J. Rossi