Patents by Inventor Desheng Kong

Desheng Kong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220135665
    Abstract: The present invention belongs to the field of tumor immunotherapy, and relates to a humanized anti-VEGF antibody Fab fragment. The present invention discloses nucleic acid sequences (including heavy/light chain variable regions) encoding said antibody fragment, and vectors, pharmaceutical compositions and kits containing said nucleic acid sequences. The anti-VEGF antibody Fab fragments disclosed in the present invention can specifically bind to VEGF with high affinity and block the binding of VEGF to the receptor VEGFR2, and also neutralize the proliferative effect of VEGF on HUVEC cells. Compared to the full-length antibody, antibodies in the form of Fab fragments have stronger penetrability and less toxic in terms of gastrointestinal perforation, hypertension and hemorrhage and do not stimulate the complement cascade reaction, thus reducing the risk of endophthalmitis and autoimmune inflammatory reactions.
    Type: Application
    Filed: January 18, 2022
    Publication date: May 5, 2022
    Inventors: Liangzhi Xie, Chunyun Sun, Jun Zhao, Desheng Kong
  • Patent number: 10431757
    Abstract: An electronic or optoelectronic device includes: (1) a semiconductor layer; (2) a dielectric layer in contact with the semiconductor layer and including a polar elastomer; and (3) an electrode. The dielectric layer is disposed between the electrode and the semiconductor layer, and the polar elastomer includes a backbone structure and polar groups that are bonded as side chains to the backbone structure, and each of the polar groups includes 2 or more atoms.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: October 1, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhenan Bao, Chao Wang, Wen Ya Lee, Guillaume Schweicher, Desheng Kong
  • Publication number: 20180351120
    Abstract: An electronic or optoelectronic device includes: (1) a semiconductor layer; (2) a dielectric layer in contact with the semiconductor layer and including a polar elastomer; and (3) an electrode. The dielectric layer is disposed between the electrode and the semiconductor layer, and the polar elastomer includes a backbone structure and polar groups that are bonded as side chains to the backbone structure, and each of the polar groups includes 2 or more atoms.
    Type: Application
    Filed: April 23, 2018
    Publication date: December 6, 2018
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhenan Bao, Chao Wang, Wen Ya Lee, Guillaume Schweicher, Desheng Kong
  • Patent number: 9954191
    Abstract: An electronic or optoelectronic device includes: (1) a semiconductor layer; (2) a pair of electrodes electrically coupled to the semiconductor layer; and (3) a dielectric layer in contact with the semiconductor layer and including a polar elastomer, where the elastomer has a glass transition temperature Tg that is no greater than 25° C.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: April 24, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhenan Bao, Chao Wang, Wen Ya Lee, Guillaume Schweicher, Desheng Kong
  • Publication number: 20170098791
    Abstract: An electronic or optoelectronic device includes: (1) a semiconductor layer; (2) a pair of electrodes electrically coupled to the semiconductor layer; and (3) a dielectric layer in contact with the semiconductor layer and including a polar elastomer, where the elastomer has a glass transition temperature Tg that is no greater than 25° C.
    Type: Application
    Filed: April 16, 2015
    Publication date: April 6, 2017
    Inventors: Zhenan Bao, Chao Wang, Wen Ya Lee, Guillaume Schweicher, Desheng Kong