Abstract: This invention provides modified IGFBP-derived peptides—collectively termed “immodulator peptides”—and related compositions and methods. Chemical modifications to peptides using small molecules, and sequence extensions to immodulator core sequences exhibit new and surprising biological activities. The invention builds the combinatorial power of the immodulator peptide class further by demonstrating which core sequences bind metal or glycosaminoglycans such as heparin. The invention discloses some surprising biological properties of compositions derived from these modifications, including a host of new therapeutic and diagnostic utilities (e.g. immune modulation of TLR signaling, enhanced collagen synthesis by skin fibroblasts, and synergy with a RIG-1 agonist in killing melanoma cells). The invention also teaches methods for enhancing previously disclosed uses of immodulator peptides by showing how the modifications of the invention can boost the efficacy of immodulator peptides in a model of burn trauma.

Abstract: Stress, such as from physical, metabolic or psychological trauma, is associated with enduring secondary complications leading to morbidity and/or death in subjects that receive the stress insult. The epigenetic oxidative stress response to a stress insult is characterized by (a) global epigenetic events such as changes in DNA methylation and phosphorylation of Ser10 and acetylation of Lys9/14 residues of histone-3 (b) significant systemic elevations in analytes of oxidative stress in body fluids such as blood or urine and (c) deterioration of clinically relevant parameters such as glycemic control, organ function, lean body mass and rate of healing. The applicant teaches a method of counteracting the grave systemic effects of stress insult with reference to the epigenetic oxidative stress response, by daily subcutaneous bolus injections of nephrilin peptide beginning soon after insult and continuing for seven days.

Abstract: The present invention is related to methods and compositions useful in the detection and treatment of epigenetic changes during traumatic, autoimmune and other disease processes. The methods described herein comprise identifying and using certain agents to modulate pathophysiological processes in animal and human subjects. The methods of the invention may be used for therapeutic or diagnostic purposes.

Abstract: The present invention is related to methods and compositions useful in the detection and treatment of epigenetic changes during traumatic, autoimmune and other disease processes. The methods described herein comprise identifying and using certain agents to modulate pathophysiological processes in animal and human subjects. The methods of the invention may be used for therapeutic or diagnostic purposes.

Abstract: The present invention is related to methods and compositions useful in the detection and treatment of epigenetic changes during traumatic, autoimmune and other disease processes. The methods described herein comprise identifying and using certain agents to modulate pathophysiological processes in animal and human subjects. The methods of the invention may be used for therapeutic or diagnostic purposes.

Abstract: The present invention provides a system and method for creating and maintaining a Biomedical document database, wherein the documents have been reviewed by biomedical and other experts, who have assigned taxonomic based indicia to each document wherein a specialized search engine can rapidly retrieve relevant documents based upon the commnly known taxonomy.

Abstract: The present invention provides a method, system, and computer product to evaluate a user's learning style. The user is presented with a series of interactive assessment exercises, wherein each exercise contains one or more clues, a number of correct cards, and a number of incorrect cards. The user's responses, which include the types and number of moves made, the time it takes to select another card, and the like are received, recorded, or captured. Based on the user's responses, the responses are evaluated and used in a learning style formula to determine the learning style of a user. The invention also provides for a method, system, and computer product that evaluate a user's comprehension of a certain topic or subject matter. The user is presented with an interactive assessment exercise, wherein such exercise contains one or more clues, a number of correct cards, and a number of incorrect cards.

Abstract: The present invention provides a method, system, and computer product to evaluate a user's learning style. The user is presented with a series of interactive assessment exercises, wherein each exercise contains one or more clues, a number of correct cards, and a number of incorrect cards. The user's responses, which include the types and number of moves made, the time it takes to select another card, and the like are received, recorded, or captured. Based on the user's responses, the responses are evaluated and used in a learning style formula to determine the learning style of a user. The invention also provides for a method, system, and computer product that evaluate a user's comprehension of a certain topic or subject matter. The user is presented with an interactive assessment exercise, wherein such exercise contains one or more clues, a number of correct cards, and a number of incorrect cards.