Abstract: The invention relates to a method for operating a drive device (1) of a motor vehicle, comprising an internal combustion engine (2) having a first exhaust gas turbocharger (5) and a second exhaust gas turbocharger (6), and comprising at least one electric machine (3), wherein the exhaust gas turbochargers (5, 6) are connected in series, wherein at least the second exhaust gas turbocharger (6) has means for varying the output thereof, and wherein the output at least of the second exhaust gas turbocharger (6) is varied in accordance with a required target torque of the drive device (1). According to the invention, the electric machine (3) is controlled in accordance with the time of the variation, in order to compensate for a deviation of an actual torque of the drive device (1) from the target torque.