Abstract: A heat exchanger having a heat transfer surface provided with hyperthermophilic bacteria. The hyperthermophilic bacteria can be from the genera Archaea. The hyperthermophilic bacteria can further be from the genus Sulfolobus, and the hyperthermophilic bacteria can further be from the species Sulfolobus solfataricus. The heat exchanger can be adapted to pool-boiling heat transfer.

Abstract: A heat exchanger having a heat transfer surface provided with hyperthermophilic bacteria. The hyperthermophilic bacteria can be from the genera Archaea. The hyperthermophilic bacteria can further be from the genus Sulfolobus, and the hyperthermophilic bacteria can further be from the species Sulfolobus solfataricus. The heat exchanger can be adapted to pool-boiling heat transfer.

Abstract: The present invention relates to oligonucleotide carriers for oligonucleotide delivery to a subject to provide gene therapy. More particularly, the present invention relates to therapeutic nanoparticles for microRNA (miRNA) delivery to a subject. More particularly, the present invention relates to therapeutic nanoparticles wherein miRNA is bindable to biocompatible nanoparticles using natural gene carrier Argonaute (AGO) protein or a variant thereof. Optionally, therapeutic nanoparticles of the present invention additionally contain targeting moieties for targeting therapeutic nanoparticles to cancer cells and/or chemotherapeutic agents. Optionally, biocompatible nanoparticles are trackable nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), to provide multifunctional theranostics.

Abstract: A device for single-cell analysis according to an embodiment of the present invention comprises: a substrate; a gap between the substrate and porous membrane which is a space for culture medium; and a porous membrane formed on having a pore capable of isolating a second cell into single cell units. A method for single-cell analysis according to an embodiment of the present invention comprises: Culturing a first cell in a culture medium on a bottom side of porous membrane; Applying a sample including a second cell on a porous membrane in a culture medium; Isolating the second cell into single cell units in a pore existing in the porous membrane with a external force such as agitation and gravitational force; Generating an interaction situation between the first cells and the single cell-level second cell; Analyzing a cellular phenomena of the first cell or the second cell.

Abstract: A device for single-cell analysis according to an embodiment of the present invention comprises: a substrate; a gap between the substrate and porous membrane which is a space for culture medium; and a porous membrane formed on having a pore capable of isolating a second cell into single cell units. A method for single-cell analysis according to an embodiment of the present invention comprises: Culturing a first cell in a culture medium on a bottom side of porous membrane; Applying a sample including a second cell on a porous membrane in a culture medium; Isolating the second cell into single cell units in a pore existing in the porous membrane with a external force such as agitation and gravitational force; Generating an interaction situation between the first cells and the single cell-level second cell; Analyzing a cellular phenomena of the first cell or the second cell.

Abstract: The invention is use of at least one miRNA (micro Ribonucleic Acid) being member of the hsa-miR-376 family or at least one inhibitor of said miRNA for the diagnosis, prophylaxis, treatment and follow-up during and after treatment of at least one disease involving autophagy abnormalities by acting on autophagy-related genes and proteins; and method thereof.