Abstract: The present invention relates to a compound of formula (I) capable of inhibiting plasmin activity and having blood coagulation and hemostasis activity, and a pharmaceutically acceptable salt, hydrate, isomer, prodrug and mixture thereof, wherein R1 to R3 are as defined in the description.

Abstract: A fault root cause identification method, apparatus, and device. For a failure flow that occurs when a connectivity fault for access in a network occurs, a target success flow that has a high similarity with the failure flow is determined from a plurality of success flows in the network based on the failure flow. Then, a target fault root cause of the failure flow is obtained based on the failure flow, the target success flow, and a trained first machine learning model. In this way, the target success flow related to the failure flow is determined from the plurality of success flows in the network, and the first machine learning model trained by using a large quantity of success flows and failure flows whose feature indicators are slightly different from each other is used.

Abstract: An automobile hub fixture includes a fixture body and a positioning apparatus. The fixture body includes a fixed platform and a plurality of clamping claws arranged at intervals in a circumferential direction of the fixed platform. The clamping claws are configured to clamp an outer rim of a hub. The plurality of clamping claws are connected to a driving member by using a linkage, and the driving member drives the clamping claws to radially move along the fixed platform. The positioning apparatus includes a movable platform slidably connected to the clamping claws. A positioning module configured to position an inner rim or the outer rim of the hub is mounted to the movable platform. The machining device includes a fixture, a machine tool, and a minimal quantity lubrication apparatus. The production line includes a machining device, a loading system, a loading and unloading manipulator, and a catching table.

Abstract: Disclosed are a macrocyclic fluorine-containing heterocyclic derivative of formula (I), a preparation method thereof, and a use thereof in treatment of TRK kinase-mediated diseases.