Patents by Inventor Dharmaraj Ramachandra Rao

Dharmaraj Ramachandra Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RIFAXIMIN COMPLEXES
    Publication number: 20230181741
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Application
    Filed: July 12, 2022
    Publication date: June 15, 2023
    Applicant: CIPLA LIMITED
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • RIFAXIMIN
    Publication number: 20230116935
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: May 17, 2022
    Publication date: April 20, 2023
    Applicant: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Maruti Ghagare
  • Salts of antiviral phosphonate analogues and process for preparation thereof
    Patent number: 11390637
    Abstract: The present invention relates to certain acid salts of (((1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methyl)(phenoxy) phosphoryloxy)methyl pivalate of Formula (I), to processes for their preparation; to pharmaceutical compositions comprising such compounds, and methods of treating a disease which responds to inhibition of nucleotide reverse transcriptase activity.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: July 19, 2022
    Assignee: Cipla Limited
    Inventors: Manjinder Singh Phull, Ashwini Amol Sawant, Dharmaraj Ramachandra Rao, Geena Malhotra, Manish Gopaldas Gangrade
  • Process for the preparation of piperine
    Patent number: 11267798
    Abstract: The present application relates to a process for the preparation of piperine of high purity having low concentrations of isomeric impurities.
    Type: Grant
    Filed: October 13, 2018
    Date of Patent: March 8, 2022
    Assignee: CIPLA LIMITED
    Inventors: Manjinder Singh Phull, Dharmaraj Ramachandra Rao, Geena Malhortra, Dilip Ramdas Birari, Sachin Vasant Desai
  • PROCESS FOR THE PREPARATION OF PIPERINE
    Publication number: 20210363126
    Abstract: The present application relates to a process for the preparation of piperine of high purity having low concentrations of isomeric impurities.
    Type: Application
    Filed: October 13, 2018
    Publication date: November 25, 2021
    Inventors: Manjinder Singh PHULL, Dharmaraj Ramachandra RAO, Geena MALHORTRA, Dilip Ramdas BIRARI, Sachin Vasant DESAI
  • New Polymorphs of Dolutegravir Sodium
    Publication number: 20210040116
    Abstract: The present invention relates to new polymorphs of dolutegravir sodium and processes for the preparation of the new polymorphs of dolutegravir sodium. The present invention also provides pharmaceutical compositions comprising these new polymorphs, and medical uses of the polymorphs.
    Type: Application
    Filed: September 7, 2017
    Publication date: February 11, 2021
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Manjinder Singh PHULL, Ashwini Amol SAWANT, Amit NAIK, Manish Gopaldas GANGRADE, Shashirekha KANATHALA
  • POLYMORPHIC FORMS OF (9-[(R)-2-[[(S)-[[(S)-1-(ISOPROPOXYCARBONYL)ETHYL]AMINO]PHENOXY PHOSPHINYL]METHOXY]PROPYL] ADENINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
    Publication number: 20200407382
    Abstract: The present invention discloses novel crystalline polymorphic forms of (9-[(R)-2-[[(S)-[[(S)-1-(isopropoxy carbonyl) ethyl] amino] phenoxyphosphinyl] methoxy]propyl] adenine hemifumarate and 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl] amino]phenoxy phosphinyl]methoxy]propyl] adenine monofumarate, methods of preparation, pharmaceutical compositions and methods of therapeutic treatment involving polymorphic forms thereof.
    Type: Application
    Filed: December 28, 2018
    Publication date: December 31, 2020
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Manjinder Singh PHULL, Ramanaiah CHENNURU
  • RIFAXIMIN
    Publication number: 20200368212
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: February 28, 2020
    Publication date: November 26, 2020
    Applicant: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Muruti Ghagare
  • Rifaximin
    Patent number: 10702505
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: July 7, 2020
    Assignee: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Muruti Ghagare
  • RIFAXIMIN COMPLEXES
    Publication number: 20200147225
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Application
    Filed: June 13, 2019
    Publication date: May 14, 2020
    Applicant: Cipla Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Salts of Antiviral Phosphonate Analogues and Process for Preparation Thereof
    Publication number: 20200131211
    Abstract: The present invention relates to certain acid salts of (((1-(6-amino-9H-purin-9-yl)propan-2-yloxy)methyl)(phenoxy) phosphoryloxy)methyl pivalate of Formula (I), to processes for their preparation; to pharmaceutical compositions comprising such compounds, and methods of treating a disease which responds to inhibition of nucleotide reverse transcriptase activity.
    Type: Application
    Filed: March 16, 2018
    Publication date: April 30, 2020
    Inventors: Manjinder Singh PHULL, Ashwini Amol SAWANT, Dharmaraj Ramachandra RAO, Geena MALHOTRA, Manish Gopaldas GANGRADE
  • Polymorphs of Dasatinib
    Publication number: 20190270735
    Abstract: The present invention provides novel polymorphic forms of dasatinib compound of the formula 1 as well as the process for the preparation thereof.
    Type: Application
    Filed: October 30, 2017
    Publication date: September 5, 2019
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Ravikumar PUPPALA, Yellanki JAGANNADHAM, Ramanaiah CHENNURU
  • Stable Pharmaceutical Composition of Vortioxetine Hydrobromide
    Publication number: 20190224192
    Abstract: The present invention relates to novel premixes of Vortioxetine, processes for the preparation of such premixes, pharmaceutical compositions comprising the same and their use in medicine.
    Type: Application
    Filed: August 29, 2017
    Publication date: July 25, 2019
    Inventors: Geena MALHOTRA, Dharmaraj Ramachandra RAO, Venkata Srinivas PULLELA, Preeti RAUT, Shrikant Suresh MUDGAL, Pratap Ramesh SAWANT, Jinesh CHAUHAN, Nidhi BAGREE
  • Rifaximin complexes
    Patent number: 10328153
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: June 25, 2019
    Assignee: Cipla Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Polymorphic form X of nilotinib dihydrochloride hydrate
    Patent number: 10301282
    Abstract: The present invention relates to a novel polymorph of nilotinib hydrochloride (Form X), to processes for its preparation, to pharmaceutical compositions containing the same and to its use in medicine.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: May 28, 2019
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Srinivas Laxminarayan Pathi, Venugopalarao Chinimilli, Manish Gopaldas Gangrade
  • Polymorphic forms of methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate and salts thereof
    Patent number: 10300044
    Abstract: Amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate free base, amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate dihydrochloride, methods of making them, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: May 28, 2019
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Manjinder Singh Phull, Shashirekha Kanathala, Manish Gopaldas Gangrade
  • Process for the preparation of apremilast
    Patent number: 10287248
    Abstract: The present invention relates to novel processes for the preparation of apremilast of formula I, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: May 14, 2019
    Assignee: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Suryanarayana Durga Yarra
  • PROCESS FOR THE PREPARATION OF GUANYLATE CYCLASE 2C AGONIST
    Publication number: 20190055278
    Abstract: The present invention relates to an improved process for the preparation of Linaclotide of Formula I. The process disclosed in the present invention is simple, economical and eco-friendly with reduced reaction times.
    Type: Application
    Filed: February 3, 2017
    Publication date: February 21, 2019
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Venkata Srinivas PULLELA, Parag Shankar KURLE, Rakesh MENDHE
  • Process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts and intermediates thereof
    Patent number: 10208058
    Abstract: The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts thereof and to novel intermediates which are produced during the course of carrying out the novel process.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: February 19, 2019
    Assignee: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Venkata Srinivas Pullela, Vinod Parameshwaran Acharya, Nagarjuna Reddy Vantadou
  • RIFAXIMIN COMPLEXES
    Publication number: 20180289817
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Application
    Filed: June 11, 2018
    Publication date: October 11, 2018
    Applicant: Cipla Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan